Wiberg, Kenneth B. et al. published their research in Journal of Organic Chemistry in 2019 | CAS: 6581-66-4

2-Methoxytetrahydro-2H-pyran (cas: 6581-66-4) belongs to tetrahydropyran derivatives. Dihydropyrans and tetrahydropyrans are examples of cyclic ethers widespread in nature. The Prins reaction of homoallylic alcohols with aldehydes afforded an alternative method for the preparation of tetrahydropyrans.Related Products of 6581-66-4

Unrecognized Intramolecular and Intermolecular Attractive Interactions between Fluorine-Containing Motifs and Ether, Carbonyl, and Amino Moieties was written by Wiberg, Kenneth B.;Bailey, William F.;Lambert, Kyle M.. And the article was included in Journal of Organic Chemistry in 2019.Related Products of 6581-66-4 This article mentions the following:

In order to elucidate to what extent Coulombic and other interactions contribute to the origins of contrasteric phenomena, we have identified a significant, previously unrecognized interaction between fluorine-containing motifs and groups or mols. containing main-group heteroatoms. The axial conformers of both 2-methoxy- and 2-trifluoromethoxytetrahydropyrans preferentially adopt a rotameric arrangement in which the OCH3 and the OCF3 groups are gauche to the ring oxygen. Given that one would expect a repulsive Columbic interaction to exist between the electroneg. fluorines of the CF3 group and the ring oxygen in this rotameric orientation, this surprising result suggests that an attractive interaction exists between the CF3 group and the oxygen of the ring. The generality and origin of this interaction was examined using nonpolar CF4 to probe intermol. interactions with systems such as di-Me ether, trimethylamine, trimethylphosphine, and acetone. In each case there was an attractive interaction leading to formation of a complex. The attraction is not due to van der Waals forces. Rather, the fluorine lone pairs of the CF4 often act as an electron donor in these complexes leading to a transfer of charge between the reactants and formation of the complex. These previously unrecognized fluorine-heteroatom interactions likely play a significant role in the context of understanding the binding interactions of medicinally relevant mols. or pharmaceuticals possessing fluorine-containing pharmacophores with their targets. In the experiment, the researchers used many compounds, for example, 2-Methoxytetrahydro-2H-pyran (cas: 6581-66-4Related Products of 6581-66-4).

2-Methoxytetrahydro-2H-pyran (cas: 6581-66-4) belongs to tetrahydropyran derivatives. Dihydropyrans and tetrahydropyrans are examples of cyclic ethers widespread in nature. The Prins reaction of homoallylic alcohols with aldehydes afforded an alternative method for the preparation of tetrahydropyrans.Related Products of 6581-66-4

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics