Exploration of scientific connotation of processing of Shanzhuyu (Corni Fructus) with wine based on network pharmacology was written by Wu, Xinhua;Qu, Hui;Cao, Yuan;Fang, Zhuyuan. And the article was included in Zhonghua Zhongyiyao Xuekan in 2021.HPLC of Formula: 17388-39-5 This article mentions the following:
Objective: Processing with wine is one of the important processing methods of Shanzhuyu (Corni Fructus), which may significantly enhance its effects of nourishing liver and kidney, as well as preventing decrepitude and strengthening immunity. This study aimed to clarify the mol. mechanism of how the ingredient variation affected the efficacy of processed Shanzhuyu (Corni Fructus), and elucidate the scientific connotation of this processing methodol. based on network pharmacol. Methods: The major different ingredients between crude and processed Shanzhuyu (Corni Fructus) were screened out based on literature. The potential targets of these ingredients were predicted according to SIB, SEA, STITCH, TCMSP database, and the core targets were selected out by STRING database and Metascape. Cytoscape software were used to construct protein-protein interactions network and ingredient-target network. GO function and KEGG pathways involved in the targets were analyzed by DAVID database. BioGps database was used to locate the target organs. Results: Nine differential components and 43 core targets were screened out. The network anal. results showed that 85 GO terms and 14 KEGG pathways were involved. The results of organ localization showed that the core disease site was liver. Conclusion: The changes in the efficacy between crude and processed Shanzhuyu (Corni Fructus) resulted from chem. composition alteration and their interactions. The enhancement of pharmaceutical efficacy of processed Shanzhuyu (Corni Fructus) may be accomplished by regulation of neuroactive ligand-receptor interaction, cAMP signaling pathway, PI3K-Akt signaling pathway and so on. In the experiment, the researchers used many compounds, for example, (4aR,5R,6S)-4a-Hydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-5-vinyl-4,4a,5,6-tetrahydropyrano[3,4-c]pyran-1(3H)-one (cas: 17388-39-5HPLC of Formula: 17388-39-5).
(4aR,5R,6S)-4a-Hydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-5-vinyl-4,4a,5,6-tetrahydropyrano[3,4-c]pyran-1(3H)-one (cas: 17388-39-5) belongs to tetrahydropyran derivatives. Numerous natural products have tetrahydropyran skeleton as the building block for designing new natural products and their derivatives e.g. aplysiatoxins, avermectins, oscillatoxins, talaromycins, latrunculins and acutiphycins. One classic procedure for the organic synthesis of tetrahydropyran is by hydrogenation of the 3,4-isomer of dihydropyran with Raney nickel.HPLC of Formula: 17388-39-5
Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics