108-55-4, Dihydro-2H-pyran-2,6(3H)-dione is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Curcumin 8 (100 mg, 0.27 mmol) and glutaric anhydride (31 mg, 0.27 mmol) were dissolved in toluene (15 ml). DMAP (39 mg, 0.32 mmol) was added followed by TEA (150 L, 1 mmol). The reaction mixture was stirred refluxed under inert gas for 6 h. The solvent was evaporated under vacuum. The orange precipitate was re-dissolved in ethyl acetate (50 mL) and washed with 1M HCl (5 mL). The organic phase was extracted, and the solvent was removed and dried. The crude product was purified via column chromatography using CH2Cl2:CH3OH (95:5 (v/v) as eluent. MS (ESI) [C26H26O9]: Calcd: 482.4792 Found: 483.2623 [M + H]+ and 505.2484 [M + Na]+. 1HNMR (CDCl3, 400 MHz, delta ppm): 2.08-2.11 (m, 2H), 2.55 (t, J =11.1Hz, 2H), 2.69 (t, J = 10.8, 2H), 3.86 (s, 3H), 3.93 (s, 3H), 5.81 (s, 2H), 6.44-6.55 (m, 3H), 6.91 (d, 1H), 7.09-7.61 (m, 7H). 13C NMR (CDCl3, 100 MHz, delta ppm): 19.99, 32.22, 32.74, 55.88, 101.42, 101.96, 109.72, 111.52, 114.91, 120.91, 122.24, 123.28, 124.27, 127.00, 134.15, 139.39, 140.96, 141.18, 146.65, 148.54, 151.60, 170.84, 175.56, 181.79, 184.64., 108-55-4
108-55-4 Dihydro-2H-pyran-2,6(3H)-dione 7940, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Article; Darwish, Shaban; Mozaffari, Saghar; Parang, Keykavous; Tiwari, Rakesh; Tetrahedron Letters; vol. 58; 49; (2017); p. 4617 – 4622;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics