With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108-55-4,Dihydro-2H-pyran-2,6(3H)-dione,as a common compound, the synthetic route is as follows.
Intermediate 1: 5-(Benzyloxy)-5-oxopentanoic AcidDissolve glutaric anhydride (8.76¡Á10-2 mol) in dichloromethane (300 ml) and place under stirring. Add 4-dimethylaminopyridine (7.88¡Á10-2 mol) and benzyl alcohol (7.88¡Á10-2 mol) and then leave the reaction mixture at ambient temperature. After 4 hours and 30 minutes, the mixture is hydrolysed with aqueous 5% sodium carbonate solution (200 ml). Separate the two phases by decanting. The aqueous phase is then acidified with aqueous 1M hydrochloric acid solution and subsequently extracted with ethyl acetate. The organic phase is washed with brine, dried over magnesium sulphate, filtered and evaporated to dryness under reduced pressure.The title product is obtained in the form of a white solid which is used without subsequent purification., 108-55-4
108-55-4 Dihydro-2H-pyran-2,6(3H)-dione 7940, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; LES LABORATOIRES SERVIER; US2010/286225; (2010); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics