101691-94-5, 4-(Iodomethyl)tetrahydro-2H-pyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
All starting materials were evaporated with toluene several times and all glassware was dried in an oven overnight. To a -78 C. solution of LiHMDS (5.91 mL, 5.91 mmol) in THF (15 mL) was added dropwise a solution of Part A(iv) compound(1.0 g, 2.81 mmol) in THF (15 mL) over 15 min. The reaction was stirred at -78 C. for 15 min, then was warmed to 0 C. for 45 min and recooled to -78 C. Distilled DMPU (0.714 mL, 5.91 mmol) was added and the reaction was stirred at -78 C. for 15 min, after which Part A(v) iodide (0.954 g, 4.22 mmol) was added. The reaction was stirred at -78 C. for 1 h, then was slowly warmed to RT and stirred for 18 h. The reaction was quenched with sat. aqueous NH4Cl (10 mL) and diluted with EtOAc. The mixture was washed with H2O. The aqueous layer was extracted with EtOAc, and the combined organic extracts were washed with brine, dried [MgSO4] and concentrated in vacuo to give Part A(vi) compound (1.3 g, 100%) as a yellow oil., 101691-94-5
The synthetic route of 101691-94-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Bristol-Myers Squibb Company; US2008/9465; (2008); A1;,
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