65412-03-5, 4-(2-Aminoethyl)tetrahydro-2H-pyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
65412-03-5, General procedure: To a 20 mL vial was weighed (S)-3-(methylcarbamoyl)-1-(1-phenylethyl)-1H-pyrazole-5-carboxylic acid (0.027 g, 0.1 mmol) x 14 = 383 mg and HATU (0.042 g, 0.110 mmol) x 14 = 586 mg. To this vial was added DMF (0.5 mL) x 14 = 7 mL and DIPEA (0.050 mL, 0.286 mmol) x 14 = 700 muL. The mixture was stirred for 5 min and then aliquoted into vials (550 muL) each containing the appropriate pre-weighed amine (0.120 mmol). (NOTE: additional DIPEA (0.050 mL, 0.286 mmol) was added to amines which were HCl salts). The mixture was allowed to react for 66 h. T3P (100 muL, 50 wt% in EtOAc) and DIPEA (0.050 mL, 0.286 mmol) were added and after 5 min additional amine (0.120 mmol) was added. The mixtures were reacted for a further 24 h. The reactions were purified by MDAP (High pH) and concentrated to give:-
As the paragraph descriping shows that 65412-03-5 is playing an increasingly important role.
Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED; ATKINSON, Stephen John; DEMONT, Emmanuel Hubert; HARRISON, Lee Andrew; LIWICKI, Gemma Michele; LUCAS, Simon Christopher Cranko; PRESTON, Alexander G; SEAL, Jonathan, Thomas; WALL, Ian David; WATSON, Robert J; (0 pag.)WO2018/158212; (2018); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics