125552-89-8, 4-(Bromomethyl)tetrahydropyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Add 4-oxo-5- (p-tolyl) -1,4-dihydropyridine-3-carboxylic acid ethyl ester (1.56 g, 6.1 mmol, 1.0 eq) to DMF (45 mL), and then add cesium carbonate (3.96g, 12.2mmol, 2.0eq)And 4- (bromomethyl) tetrahydro-2H-pyran (1.2 g, 6.7 mmol, 1.1 eq), heated to 100 C. and reacted overnight. After detecting the reaction by TLC and LC-MS, cool to room temperature, add water (100 mL), separate the layers, extract the aqueous phase with ethyl acetate (50 mL ¡Á 5), wash with saturated brine (50 mL ¡Á 3), dry, filter, and concentrate. The crude product was subjected to silica gel column chromatography to obtain a yellow solid (1.2 g, 77%).
125552-89-8, The synthetic route of 125552-89-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Nanjing Yaojie Good Health Biological Technology Co., Ltd.; Wu Yongqian; Li Lin; Wan Zhonghui; (107 pag.)CN110041316; (2019); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics