2081-44-9, Tetrahydro-2H-pyran-4-ol is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of tetrahydropyran-4-ol (15.0 g, 146 mmol, 14.71 mL) in dichloromethane (600 mL) was added PPh3 (50.0 g, 191 mmol) and imidazole (15.0 g, 220 mmol). The mixture was stirred at 0 C and iodine (44.7 g, 176 mmol) was added in portions under a nitrogen atmosphere. Finally, the mixture was stirred at 15 C for 16 hours. On completion, the reaction mixture was filtered and the filtrate was concentrated in vacuo to get a residue. The residue was diluted with water (150 mL) and extracted with ethyl acetate (3 ¡Á 150 mL). The combined organic layers were dried over anhydrous Na2SO4, filtered and concentrated in vacuo to give a residue. The residue was purified by column chromatography (petroleum ether: dichloromethane = 1:0 to 2:1) to give the title compound (16.0 g, 51% yield) as a colorless oil.1H NMR (400MHz, CDCl3) delta = 4.48 – 4.41 (m, 1H), 3.80 (td, J = 4.4, 11.6 Hz, 2H), 3.56 – 3.46 (m, 2H), 2.20 – 2.09 (m, 4H).
2081-44-9, The synthetic route of 2081-44-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; RAZE THERAPEUTICS, INC.; MAINOLFI, Nello; (215 pag.)WO2018/106636; (2018); A1;,
Tetrahydropyran – Wikipedia
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