With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.951127-25-6,tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate,as a common compound, the synthetic route is as follows.
951127-25-6, N-[(2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydropyran-3-yl]carboxylic acidTert-butyl ester(0.25g,0.76 mmol) was dissolved in N,N-dimethylacetamide (3.3 mL).2-[(5-Methyl-2-thienyl)sulfonyl]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole 4-methylbenzenesulfonate (0.47 g) , 1.06mmol), react at room temperature for 10 minutes,Nitrogen protection, sodium triacetoxyborohydride (0.89 g, 4.19 mmol) was slowly added at 0 C.The reaction was resumed at room temperature for 12 hours. The reaction was quenched by the addition of aqueous ammonia/water (v/v = 2/3, 50 mL).filter,The obtained solid was subjected to silica gel column chromatography[Methanol/dichloromethane (v/v) = 1/9] purified,The title compound (0.41 g, yield 92%) was obtained.It is a white solid.
As the paragraph descriping shows that 951127-25-6 is playing an increasingly important role.
Reference£º
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Ruyuan Yong Xing Technology Services Co., Ltd.; Li Jianhao; Gu Zheng; Deng Xinshan; Tang Wanjun; Zhang Zongyuan; Kang Panpan; Yuan Weihui; Peng Fei; (49 pag.)CN109942583; (2019); A;,
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