Simple exploration of 220641-87-2

As the paragraph descriping shows that 220641-87-2 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.220641-87-2,N-Methyltetrahydro-2H-pyran-4-amine,as a common compound, the synthetic route is as follows.,220641-87-2

[01465] Step 1 : Synthesis of methyl 3,6-dichloro-4-[methyl(oxan-4-yl)amino]pyridine-2- carboxylate – – – -[01466] To a stirred solution of methyl 3,4,6-trichloropyridine-2-carboxylate (600 mg, 2.50 mmol) in DMF (12ml) was added TEA (696 mu, 4.99 mmol) followed by N-methyloxan-4- amine (287 mg, 2.50 mmol)and the reaction mixture was heated at 100C for 20h. The reaction mixture was then cooled to room temperature and poured onto water ( 100ml), followed by extraction of the product into EtOAc (3x 100ml), washing of the combined organics with brine (50ml), drying with Na2S04 and evaporation. The crude product was then purified over a l Og silica Isolute column eluting with a gradient of 0% to 60% EtOAc in heptane to afford the title compound as a white solid (1 14 mg, 14%). LC-MS 100%, 1 .91 min (3.5 minute LC-MS method), m/z= 319.3/320.9, ‘H NMR (500 MHz, Chloroform-d) 5 6.87 (s, 1 H), 4.15 – 4.00 (m, 2H), 3.98 (s, 3H), 3.93 – 3.71 (m, 1 H), 3.54 – 3.24 (m, 2H), 2.82 (s, 3H), 1.94 (dd, J = 12.1 , 4.7 Hz, 2H), 1 .70 (d, J = 10.2 Hz, 2H). (br. s., 4 H) 1 .48 (s, 9 H)

As the paragraph descriping shows that 220641-87-2 is playing an increasingly important role.

Reference£º
Patent; EPIZYME, INC.; EISAI CO., LTD.; KUNTZ, Kevin, Wayne; CHESWORTH, Richard; DUNCAN, Kenneth, William; KEILHACK, Heike; WARHOLIC, Natalie; KLAUS, Christine; ZHENG, Wanjun; WO2012/142513; (2012); A1;,
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