1197-66-6, 2,2,6,6-Tetramethyl-2H-3,5,6-trihydropyran-4-one is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Step 2. 2,2,6,64etrarnethy1tetrahydro-2Hpyran4carbonitrile: To a stirred solution of2,2,6,6-tetramethyldihydro-2H-pyran-43H)-one (30 g, 0.192 mol) in dimcthoxyethane(400 mE) was added tosylmethyl isoeyanide (48.7 g, 0,249 eq) followed by the addition oftert-butyiaieoholG4.i g. 0.326) at room temperature. The reaction mixture was cooled to0 C followed by portion-wise addition of potassium tcrt-butoxidc (53.8 g, 0.48 mol). itwas stirred at room temperature for 12 h. The reaction mixture was filtered after dilution with diethyl ether at 0 C and the residue was further washed with diethyl ether. The resultant filtrate was concentrated to provide the title compound as a yellow semi-solid (22 g, 68%)
1197-66-6, As the paragraph descriping shows that 1197-66-6 is playing an increasingly important role.
Reference£º
Patent; JANSSEN PHARMACEUTICA NV; BAKTHAVATCHALAM, Rajagopal; AHMAD, Ishtiyaque; BATTULA, Sivaramakrishna; GIJSEN, Henricus Jacobus Maria; VADIVELU, Saravanan; WALL, Mark; WO2015/23289; (2015); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics