103260-44-2, Ethyl 2-(tetrahydro-2H-pyran-4-yl)acetate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
103260-44-2, a) 2-Methyl-2-(tetrahydro-pyran-4-yl)-propionic acid ethyl ester; A solution of 1 g (tetrahydro-pyran-4-yl)-acetic acid ethyl ester [103260-44-2] in 3 ml of dry tetrahydrofuran is added dropwise to a solution of lithium dissopropyl amide (freshly prepared from 1 ml diisopropyl amine and 4. 3 ml 1. 6 M butyllithium solution in hexanes) in 5 ml of dry tetrahydrofuran at-78C. The reaction mixture is stirred for 15 minutes at-78C and then 0. 46 mi of methyl iodide are added and the mixture is allowed to warm to 0C over a period of 15 minutes. The reaction mixture is re-cooled to-78C and then a solution of lithium diisopropyl amide (freshly prepared from 1 ml diisopropyl amine and 4. 3 ml 1. 6 M butyllithium solution in hexanes) in 5 ml of dry tetrahydrofuran is added dropwise. The solution is stirred for 15 minutes at-78C and then 0. 46 ml of methyl iodide are added and the mixture is allowed to warm to room temperature. After 2 hours, the reaction mixture is quenched with 20 mi of 1M HO and then extracted with tert-butyl methyl ether (2x). The combined organic phases are washed with brine, dried over sodium sulphate and concentrated by evaporation. The title compound is obtained as a colourless oil from the residue by means of flash chromatography (SiO2 60F). Rf = 0. 27 (1 : 5 EtOAc-heptane)
103260-44-2 Ethyl 2-(tetrahydro-2H-pyran-4-yl)acetate 2773412, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; SPEEDEL EXPERIMENTA AG; WO2005/90304; (2005); A1;,
Tetrahydropyran – Wikipedia
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