With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4295-99-2,4-Cyanotetrahydro-4H-pyran,as a common compound, the synthetic route is as follows.
a 4-[[4-(2-Hydroxyethyl)phenyl]methyl]tetrahydropyran-4-carbonitrile Obtained by operating as in example 87a, from 6.3 g (62.2 mmoles) of diisopropylamine in 104 ml of tetrahydrofuran, 38.7 ml (62.0 mmoles) of a 1.6M solution of n-butyllithium in hexane, 9.3 g of 1,3-dimethylimidazolidin-2-one, 8.8 g (56.7 mmoles) of 2,3,5,6-tetrahydro-4H-pyran-4-carbonitrile (prepared according to Gibson C. S. and Johnson J. D. A., J. Chem. Soc. (1930), 2525-30) in 93 ml tetrahydrofuran and 17.7 g (62 mmoles) of the compound prepared in example 26a. After purification by chromatography on a column of silica in a hexane-ethyl acetate (1:1) mixture, there is obtained 10.5 g (yield=75.5%) oil. I.R. (film): nu (OH)=3400 cm-1; (C N)=2220 cm-1. N.M.R. (CDCl3): delta=1.55 (1H,s, exchangeable with D2 O); 1.6-1.9 (4H,m); 2.8 (2H,s); 2.8 (2H,t, J=6.75 Hz); 3.4-4.2 (6H,m); 7.1 (4H,s).
4295-99-2, The synthetic route of 4295-99-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Lipha Lyonnaise Industrielle Pharmaceutique; US5387709; (1995); A;,
Tetrahydropyran – Wikipedia
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