125552-89-8, 4-(Bromomethyl)tetrahydropyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
The title compound was prepared following the procedure for Intermediate 28, starting from 4- (bromomethyl)tetrahydro-2f/-pyran (0.16 g, 0.89 mmol) and /V-tert-butyl-2-({[2-(4-chloro-2- hydroxyphenyl)ethyl]sulfonyl}amino)benzenesulfonamide (0.20 g, 0.45 mmol) with cesium carbonate (0.22 g, 0.67 mmol) in DMF (3 mL). Purification by chromatography on silica using gradient elution 16-50 % EtOAc in heptane gave 126.4 mg (52 % yield) of the title compound. 1H NMR (500 MHz, DMSO-d6) delta ppm 1.03 – 1.13 (m, 9 H) 1.17 – 1.32 (m, 2 H) 1.48 – 1.64 (m, 2 H) 1.79 – 1.94 (m, 1 H) 2.89 – 3.04 (m, 2 H) 3.25 (td, 2 H) 3.44 – 3.55 (m, 2 H) 3.75 – 3.87 (m, 4 H) 6.91 (dd, 1 H) 7.00 (d, 1 H) 7.17 (d, 1 H) 7.27 – 7.37 (m, 1 H) 7.58 – 7.70 (m, 2 H) 7.89 (dd, 1 H) 8.01 (s, 1 H) 8.77 (s, 1 H); MS (ES ) m/z 543, 545, 547 [M-H]
125552-89-8, The synthetic route of 125552-89-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ACTURUM LIFE SCIENCE AB; SOeDERMAN, Peter; SVENSSON, Mats A; KERS, Annika; OeHBERG, Liselott; HOeGDIN, Katharina; HETTMAN, Andreas; HALLBERG, Jesper; EK, Maria; BYLUND, Johan; NORD, Johan; (0 pag.)WO2016/85392; (2016); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics