With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.185815-59-2,4-Isobutyldihydro-2H-pyran-2,6(3H)-dione,as a common compound, the synthetic route is as follows.
General procedure: To the 0.1 M toluene solution of anhydride (10 mmol), alkaloid (0.1 equiv), xanthene-9-carboxylic acid (0.2 equiv), and alcohol (1.5 equiv) were added. The reaction mixture was stirred until >90% conversion was reached (see Table 3) and the reaction was stopped by the addition of 5% HCl. The organic layer was washed once more with 5% HCl and evaporated. The oily residue was dissolved in 2% K2CO3 and washed successively with EtOAc. The aqueous solution was then carefully acidified with H3PO4 to pH 5.4 and extracted with toluene. The organic extracts were dried over Na2SO4 and evaporated in vacuo.
As the paragraph descriping shows that 185815-59-2 is playing an increasingly important role.
Reference£º
Article; Iv?i?, Trpimir; Novak, Jurica; Do?li?, Nada; Hamer?ak, Zdenko; Tetrahedron; vol. 68; 39; (2012); p. 8311 – 8317;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics