New learning discoveries about 29943-42-8

29943-42-8 Dihydro-2H-pyran-4(3H)-one 121599, aTetrahydropyrans compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29943-42-8,Dihydro-2H-pyran-4(3H)-one,as a common compound, the synthetic route is as follows.

NaH (mass fraction 60%, 5g, 125mmol) at room temperature Add slowly to tetrahydrofuran (200 mL), After the addition was complete, tetrahydro-4H-pyran-4-one (5.0 g, 50 mmol) was added. And dimethyl carbonate (10 mL, 125 mmol). The reaction system was heated to 60 C, and the reaction was stirred for 24 hours. After the reaction was detected to be complete by LC-MS, suction filtration was performed. The filtrate was adjusted to neutral pH with acid, extracted with ether, and separated. The organic phase was dried over anhydrous sodium sulfate, filtered and concentrated, and purified by silica gel column chromatography to obtain 4 -Oxotetrahydro-2H-pyran-3-carboxylic acid Methyl ester (3.6 g, 22.8%).

29943-42-8 Dihydro-2H-pyran-4(3H)-one 121599, aTetrahydropyrans compound, is more and more widely used in various.

Reference£º
Patent; Fujian Tuoxi New Materials Technology Co., Ltd.; Weng Songqing; (8 pag.)CN110407843; (2019); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics