Category: 11024-24-1

Loss of C2orf69 defines a fatal autoinflammatory syndrome in humans and zebrafish that evokes a glycogen storage-associated mitochondriopathy was written by Wong, Hui Hui;Seet, Sze Hwee;Maier, Michael;Gurel, Ayse;Traspas, Ricardo Moreno;Lee, Cheryl;Zhang, Shan;Talim, Beril;Loh, Abigail Y. T.;Chia, Crystal Y.;Teoh, Tze Shin;Sng, Danielle;Rensvold, Jarred;Unal, Sule;Shishkova, Evgenia;Cepni, Ece;Nathan, Fatima M.;Sirota, Fernanda L.;Liang, Chao;Yarali, Nese;Simsek-Kiper, Pelin O.;Mitani, Tadahiro;Ceylaner, Serdar;Arman-Bilir, Ozlem;Mbarek, Hamdi;Gumruk, Fatma;Efthymiou, Stephanie;Ugurlu Cimen, Deniz;Georgiadou, Danai;Sotiropoulou, Kortessa;Houlden, Henry;Paul, Franziska;Pehlivan, Davut;Laine, Candice;Chai, Guoliang;Ali, Nur Ain;Choo, Siew Chin;Keng, Soh Sok;Boisson, Bertrand;Yilmaz, Elanur;Xue, Shifeng;Coon, Joshua J.;Ly, Thanh Thao Nguyen;Gilani, Naser;Hasbini, Dana;Kayserili, Hulya;Zaki, Maha;Isfort, Robert J.;Ordonez, Natalia;Tripolszki, Kornelia;Bauer, Peter;Rezaei, Nima;Seyedpour, Simin;Khotaei, Ghamar Taj;Bascom, Charles C.;Maroofian, Reza;Chaabouni, Myriam;Alsubhi, Afaf;Eyaid, Wafaa;Isikay, Sedat;Gleeson, Joseph G.;Lupski, James R.;Casanova, Jean-Laurent;Pagliarini, David J.;Akarsu, Nurten A.;Maurer-Stroh, Sebastian;Cetinkaya, Arda;Bertoli-Avella, Aida;Mathuru, Ajay S.;Ho, Lena;Bard, Frederic A.;Reversade, Bruno. And the article was included in American Journal of Human Genetics in 2021.COA of Formula: C56H92O29 This article mentions the following:

Human C2orf69 is an evolutionarily conserved gene whose function is unknown. Here, we report eight unrelated families from which 20 children presented with a fatal syndrome consisting of severe autoinflammation and progredient leukoencephalopathy with recurrent seizures; 12 of these subjects, whose DNA was available, segregated homozygous loss-of-function C2orf69 variants. C2ORF69 bears homol. to esterase enzymes, and orthologs can be found in most eukaryotic genomes, including that of unicellular phytoplankton. We found that endogenous C2ORF69 (1) is loosely bound to mitochondria, (2) affects mitochondrial membrane potential and oxidative respiration in cultured neurons, and (3) controls the levels of the glycogen branching enzyme 1 (GBE1) consistent with a glycogen storage-associated mitochondriopathy. We show that CRISPR-Cas9-mediated inactivation of zebrafish C2orf69 results in lethality by 8 mo of age due to spontaneous epileptic seizures, which is preceded by persistent brain inflammation. Collectively, our results delineate an autoinflammatory Mendelian disorder of C2orf69 deficiency that disrupts the development/homeostasis of the immune and central nervous systems. In the experiment, the researchers used many compounds, for example, Digitonin (cas: 11024-24-1COA of Formula: C56H92O29).

Digitonin (cas: 11024-24-1) belongs to tetrahydropyran derivatives. Tetrahydropyran is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and dyestuff. The Prins reaction of homoallylic alcohols with aldehydes afforded an alternative method for the preparation of tetrahydropyrans.COA of Formula: C56H92O29

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Functionalised Graphene Quantum Dots for Cholesterol Detection in Human Blood Serum was written by Ayilliath, Shanti Krishna;Nair, Sreekanth Radhakrishnan;Lakshmi, Gopu Chandrasekharan;Kunnatheery, Sreenivasan. And the article was included in Journal of Fluorescence in 2021.Electric Literature of C56H92O29 This article mentions the following:

The varied applications of nanotechnol. have paved way for several breakthroughs in the realm of biomedical technol. In this challenging era when illness multiplies, timely and accurate disease diagnosis is very important. Thus, well founded novel approaches matter very much in areas like disease diagnosis and monitoring. Nanomedicine has tremendous implications in the given context. An elevated cholesterol concentration in blood is risky and is associated with cardiovascular diseases (CVD). CVD remains the Number 1 global cause of death and hence there is an urge to understand cholesterol level and take preventive measures. Highly fluorescent graphene quantum dots (GQs) are well known for their biocompatibility, non toxicity and aqueous solubility Here in we report an easy and sensitive non enzymic based cholesterol detection using digitonin conjugated graphene quantum dots (GDG). Selectivity studies and the cholesterol detection in human blood serum suggests the probe to be reliable and selective for blood cholesterol monitoring. In the experiment, the researchers used many compounds, for example, Digitonin (cas: 11024-24-1Electric Literature of C56H92O29).

Digitonin (cas: 11024-24-1) belongs to tetrahydropyran derivatives. Tetrahydropyrans are useful synthons for biologically important compounds. 2-(Arylmethylene)cyclopropylcarbinols could be converted to the corresponding tetrahydropyrans stereoselectively in the presence of Brønsted acids under mild conditions. A plausible Prins-type reaction mechanism has been proposed.Electric Literature of C56H92O29

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain was written by Chi, Gamma;Liang, Qiansheng;Sridhar, Akshay;Cowgill, John B.;Sader, Kasim;Radjainia, Mazdak;Qian, Pu;Castro-Hartmann, Pablo;Venkaya, Shayla;Singh, Nanki Kaur;McKinley, Gavin;Fernandez-Cid, Alejandra;Mukhopadhyay, Shubhashish M. M.;Burgess-Brown, Nicola A.;Delemotte, Lucie;Covarrubias, Manuel;Durr, Katharina L.. And the article was included in Nature Communications in 2022.HPLC of Formula: 11024-24-1 This article mentions the following:

Kv3 channels have distinctive gating kinetics tailored for rapid repolarization in fast-spiking neurons. Malfunction of this process due to genetic variants in the KCNC1 gene causes severe epileptic disorders, yet the structural determinants for the unusual gating properties remain elusive. Here, we present cryo-electron microscopy structures of the human Kv3.1a channel, revealing a unique arrangement of the cytoplasmic tetramerization domain T1 which facilitates interactions with C-terminal axonal targeting motif and key components of the gating machinery. Addnl. interactions between S1/S2 linker and turret domain strengthen the interface between voltage sensor and pore domain. Supported by mol. dynamics simulations, electrophysiol. and mutational analyses, we identify several residues in the S4/S5 linker which influence the gating kinetics and an electrostatic interaction between acidic residues in α6 of T1 and R449 in the pore-flanking S6T helixes. These findings provide insights into gating control and disease mechanisms and may guide strategies for the design of pharmaceutical drugs targeting Kv3 channels. In the experiment, the researchers used many compounds, for example, Digitonin (cas: 11024-24-1HPLC of Formula: 11024-24-1).

Digitonin (cas: 11024-24-1) belongs to tetrahydropyran derivatives. In organic synthesis, the 2-tetrahydropyranyl group is used as a protecting group for alcohols. One classic procedure for the organic synthesis of tetrahydropyran is by hydrogenation of the 3,4-isomer of dihydropyran with Raney nickel.HPLC of Formula: 11024-24-1

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Bioactivities and in silico study of Pergularia tomentosa L. phytochemicals as potent antimicrobial agents targeting type IIA topoisomerase, TyrRS, and Sap1 virulence proteins was written by Haddaji, Fatma;Papetti, Adele;Noumi, Emira;Colombo, Raffaella;Deshpande, Sumukh;Aouadi, Kaiss;Adnan, Mohd;Kadri, Adel;Selmi, Boulbaba;Snoussi, Mejdi. And the article was included in Environmental Science and Pollution Research in 2021.HPLC of Formula: 11024-24-1 This article mentions the following:

Pergularia tomentosa L. (P. tomentosa) has been largely used in Tunisian folk medicine as remedies against skin diseases, asthma, and bronchitis. The main objectives of this study were to identify phytochem. compounds that have antioxidant and antimicrobial properties from the stem, leaves, and fruit crude methanolic extracts of P. tomentosa, and to search for tyrosyl-tRNA synthetase (TyrRS), topoisomerase type IIA, and Candidapepsin-1 (SAP1) enzyme inhibitors through mol. docking study. Phytochem. quantification revealed that fruit and leaves extracts displayed the highest total flavonoids (582 mg QE/g Ex; 219 mg QE/g Ex) and tannins content (375 mg TAE/g Ex; 216 mg TAE/g Ex), also exhibiting significant scavenging activity to decrease free radicals for ABTS, DPPH, β-carotene, and FRAP assay with IC50 values (> 1 mg/mL). From the liquid chromatog.-mass spectrometry (LC-MS) anal., five polyphenolic compounds, namely digitoxigenin, digitonin glycoside and calactina in the leaves, kaempferol in the fruit, and calotropagenin in the stems, were identified. Mol. docking study affirmed that the binding affinity of calactin and actodigin to the active site of TyrRS, topoisomerase type IIA, and SAP1 target virulence proteins was the highest among the examined dominant compounds These phytocompounds could be further promoted as a candidate for drug discovery and development. In the experiment, the researchers used many compounds, for example, Digitonin (cas: 11024-24-1HPLC of Formula: 11024-24-1).

Digitonin (cas: 11024-24-1) belongs to tetrahydropyran derivatives. Numerous natural products have tetrahydropyran skeleton as the building block for designing new natural products and their derivatives e.g. aplysiatoxins, avermectins, oscillatoxins, talaromycins, latrunculins and acutiphycins. One classic procedure for the organic synthesis of tetrahydropyran is by hydrogenation of the 3,4-isomer of dihydropyran with Raney nickel.HPLC of Formula: 11024-24-1

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

An epilepsy-associated mutation in the nuclear import receptor KPNA7 reduces nuclear localization signal binding was written by Oostdyk, Luke T.;Wang, Zhenjia;Zang, Chongzhi;Li, Hui;McConnell, Michael J.;Paschal, Bryce M.. And the article was included in Scientific Reports in 2020.Reference of 11024-24-1 This article mentions the following:

KPNA7 is a member of the Importin-a family of nuclear import receptors. KPNA7 forms a complex with Importin-β and facilitates the translocation of signal-containing proteins from the cytoplasm to the nucleus. Exome sequencing of siblings with severe neurodevelopmental deffects and clin. features of epilepsy identified two amino acid-altering mutations in KPNA7. Here, we show that the E344Q substitution reduces KPNA7 binding to nuclear localization signals, and that this limits KPNA7 nuclear import activity. The P339A substitution, by contrast, has little effect on KPNA7 binding to nuclear localization signals. Given the neuronal phenotype described in the two patients, we used SILAC labeling, affinity enrichment, and mass spectrometry to identify KPNA7-interacting proteins in human induced pluripotent stem cell-derived neurons. We identified heterogeneous nuclear ribonucleoproteins hnRNP R and hnRNP U as KPNA7-interacting proteins. The E344Q substitution reduced binding and KPNA7-mediated import of these cargoes. The c.1030G > C allele which generates E344Q is within a predicted CTCF binding site, and we found that it reduces CTCF binding by approx. 40-fold. Our data support a role for altered neuronal expression and activity of KPNA7 in a rare type of pediatric epilepsy. In the experiment, the researchers used many compounds, for example, Digitonin (cas: 11024-24-1Reference of 11024-24-1).

Digitonin (cas: 11024-24-1) belongs to tetrahydropyran derivatives. Tetrahydropyrans and furans principally constitute as a central motif in diverse medicinally privileged molecules. The Prins reaction of homoallylic alcohols with aldehydes afforded an alternative method for the preparation of tetrahydropyrans.Reference of 11024-24-1

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Graphene oxide conjugated with doxorubicin: Synthesis, bioactivity, and biosafety was written by Abdelhalim, Abdelsattar O. E.;Ageev, Sergei V.;Petrov, Andrey V.;Meshcheriakov, Anatolii A.;Luttsev, Mikhail D.;Vasina, Lubov V.;Nashchekina, Iuliia A.;Murin, Igor V.;Molchanov, Oleg E.;Maistrenko, Dmitrii N.;Potanin, Artem A.;Semenov, Konstantin N.;Sharoyko, Vladimir V.. And the article was included in Journal of Molecular Liquids in 2022.Electric Literature of C56H92O29 This article mentions the following:

This work presents a method for covalent functionalization of GO with a cytostatic preparation DOX with a loading of 87%. The resulting nanomaterial was characterized using modern physicochem. methods (¹³C NMR, Raman, IR, UV/Vis spectroscopy, XPS, XRD, HRTEM). The synthesized conjugate showed significant antiaggregating activity and selective cytotoxicity towards the A549 cell line, significantly superior to individual DOX, as well as low cytotoxicity towards the non-cancer cell line HEK293. The complex biocompatibility study was conducted for the synthesized conjugate including hemocompatibility study, antioxidant activity, interaction with HSA and DNA, geno- and cytotoxicity investigation. At the same time, mol. dynamics investigation was performed in order to determine the features of intermol. interaction between GO and DOX mols. In the experiment, the researchers used many compounds, for example, Digitonin (cas: 11024-24-1Electric Literature of C56H92O29).

Digitonin (cas: 11024-24-1) belongs to tetrahydropyran derivatives. Tetrahydropyrans are also used as important solvents, as chemical intermediate and as monomer for ring-opening polymerization. The reaction of tertiary 1,4- and 1,5-diols with cerium ammonium nitrate at room temperature gives tetrahydrofuran and tetrahydropyran derivatives in high yield and stereoselectivity. Various fragrant compounds have been synthesized using this method.Electric Literature of C56H92O29

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Pregnane X receptor promotes liver enlargement in mice through the spatial induction of hepatocyte hypertrophy and proliferation was written by Tian, Jianing;Wang, Ruimin;Yang, Xiao;Yang, Jie;Zhang, Yifei;Li, Xuan;Liang, Hangfei;Fan, Shicheng;Gao, Yue;Zhang, Simin;Qu, Xiangyang;Huang, Min;Bi, Huichang. And the article was included in Chemico-Biological Interactions in 2022.COA of Formula: C56H92O29 This article mentions the following:

Nuclear receptor pregnane X receptor (PXR) can induce significant liver enlargement through hepatocyte hypertrophy and proliferation. A previous report showed that during the process of PXR-induced liver enlargement, hepatocyte hypertrophy occurs around the central vein (CV) area while hepatocyte proliferation occurs around the portal vein (PV) area. However, the features of this spatial change remain unclear. Therefore, this study aims to explore the features of the spatial changes in hepatocytes in PXR-induced liver enlargement. PXR-induced spatial changes in hepatocyte hypertrophy and proliferation were confirmed in C57BL/6 mice. The liver was perfused with digitonin to destroy the hepatocytes around the CV or PV areas, and then the regional expression of proteins related to hepatocyte hypertrophy and proliferation was further measured. The results showed that the expression of PXR downstream proteins, such as cytochrome P 450 (CYP) 3A11, CYP2B10, P-glycoprotein (P-gp) and organ anion transporting polypeptide 4 (OATP4) was upregulated around the CV area, while the expression of proliferation-related proteins such as cyclin B1 (CCNB1), cyclin D1 (CCND1) and serine/threonine NIMA-related kinase 2 (NEK2) was upregulated around the PV area. At the same time, the expression of cyclin-dependent kinase inhibitors such as retinoblastoma-like protein 2 (RBL2), cyclin-dependent kinase inhibitor 1B (CDKN1B) and CDKN1A was downregulated around the PV area. This study demonstrated that the spatial change in PXR-induced hepatocyte hypertrophy and proliferation is associated with the regional expression of PXR downstream targets and proliferation-related proteins and the regional distribution of triglycerides (TGs). These findings provide new insight into the understanding of PXR-induced hepatomegaly. In the experiment, the researchers used many compounds, for example, Digitonin (cas: 11024-24-1COA of Formula: C56H92O29).

Digitonin (cas: 11024-24-1) belongs to tetrahydropyran derivatives. Tetrahydropyran is a useful synthetic intermediate. Tetrahydropyranyl (THP-) ethers derived from the reaction of alcohols and dihydropyran are common intermediates in organic synthesis. 2-(Arylmethylene)cyclopropylcarbinols could be converted to the corresponding tetrahydropyrans stereoselectively in the presence of Brønsted acids under mild conditions. A plausible Prins-type reaction mechanism has been proposed.COA of Formula: C56H92O29

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Further insight into the mechanism of human PMN lysis following phagocytosis of Staphylococcus aureus was written by Rungelrath, Viktoria;Porter, Adeline R.;Malachowa, Natalia;Freedman, Brett A.;Leung, Jacqueline M.;Voyich, Jovanka M.;Otto, Michael;Kobayashi, Scott D.;DeLeo, Frank R.. And the article was included in Microbiology Spectrum in 2021.Computed Properties of C56H92O29 This article mentions the following:

Staphylococcus aureus is an important human pathogen that can cause a variety of diseases ranging from mild superficial skin infections to life-threatening conditions like necrotizing pneumonia, endocarditis, and septicemia. Polymorphonuclear leukocytes (PMNs; neutrophils in particular herein) are essential for host defense against S. aureus infections, and the microbe is phagocytosed readily. Most ingested bacteria are killed, but some S. aureus strains-such as the epidemic USA300 strain- have an enhanced ability to cause PMN lysis after phagocytosis. Although progress has been made, the mechanism for lysis after phagocytosis of S. aureus remains incompletely determined Here, we tested the hypothesis that disruption of phagosome integrity and escape of S. aureus from the PMN phagosome into the cytoplasm precedes PMN lysis. We used USA300 wild-type and isogenic deletion strains to evaluate and/or verify the role of selected S. aureus mols. in this cytolytic process. Compared to the wild-type USA300 strain, Δagr, Δhla, ΔlukGH, and Δpsm strains each caused significantly less lysis of human PMNs 3 h and/or 6 h after phagocytosis, consistent with previous studies. Most notably, confocal microscopy coupled with selective permeabilization assays demonstrated that phagosome membrane integrity is largely maintained prior to PMN lysis after S. aureus phagocytosis. We conclude that PMN lysis does not require escape of S. aureus from the phagosome to the cytoplasm and that these are independent phenomena. The findings are consistent with the ability of S. aureus (via selected mols.) to trigger lysis of human PMNs by an undetermined signaling mechanism. In the experiment, the researchers used many compounds, for example, Digitonin (cas: 11024-24-1Computed Properties of C56H92O29).

Digitonin (cas: 11024-24-1) belongs to tetrahydropyran derivatives. In organic synthesis, the 2-tetrahydropyranyl group is used as a protecting group for alcohols. 2-(Arylmethylene)cyclopropylcarbinols could be converted to the corresponding tetrahydropyrans stereoselectively in the presence of Brønsted acids under mild conditions. A plausible Prins-type reaction mechanism has been proposed.Computed Properties of C56H92O29

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics