Category: 112246-15-8

Silver (Ι)-assisted enantiomeric analysis of ginsenosides using electrospray ionization tandem mass spectrometry was written by Yu, Qing;Yu, Binbin;Yang, Hongmei;Li, Xue;Liu, Shuying. And the article was included in Journal of Mass Spectrometry in 2012.Category: tetrahydropyran This article mentions the following:

For identification of ginsenoside enantiomers, electrospray ionization mass spectrometry (ESI-MS) was used to generate silver complexes of the type [ginsenoside + Ag]⁺. Collision induced dissociation of the silver-ginsenoside complexes produced fragment ions by dehydration, allowing differentiation of ginsenoside enantiomers by the intensity of [M + Ag – H₂O]⁺ ion. In the meanwhile, an approach based on the distinct profiles of enantiomer-selective fragment ion intensity varied with collision energy was introduced to refine the identification and quantitation of ginsenoside enantiomers. Five pairs of enantiomeric ginsenosides were distinguished and quantified on the basis of the distribution of fragment ion [M + Ag – H₂O]⁺. This method was also extended to the identification of other type of ginsenoside isomers such as ginsenoside Rb2 and Rb3. For demonstrating the practicability of this novel approach, it was utilized to analyze the molar ratio of 20-(S) and 20-(R) type enantiomeric ginsenosides in enantiomer mixture in red ginseng extract The generation of characteristic fragment ion [M + Ag – H₂O]⁺ likely results from the reduction of potential energy barrier of dehydration because of the catalysis of silver ion. The mechanism of enantiomer identification of ginsenosides was discussed from the aspects of computational modeling and internal energy. Copyright © 2012 John Wiley & Sons, Ltd. In the experiment, the researchers used many compounds, for example, 20(R)-Ginsenoside Rh2 (cas: 112246-15-8Category: tetrahydropyran).

20(R)-Ginsenoside Rh2 (cas: 112246-15-8) belongs to tetrahydropyran derivatives. Numerous natural products have tetrahydropyran skeleton as the building block for designing new natural products and their derivatives e.g. aplysiatoxins, avermectins, oscillatoxins, talaromycins, latrunculins and acutiphycins. There is large number of marine macrolide natural products that contain tetrahydropyran and tetrahydrofuran ring together. For instance, goniodomin A (actin targeting polyether), prorocentrolide (toxin halistatins), and percentotoxineCategory: tetrahydropyran

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

20 (S)-Ginsenoside-Rh2 and 20 (R)-ginsenoside-Rh2 activated IkappaB phosphorylation expression in human lung adenocarcinoma A549 cells was written by Qi, Xiao-dan;Hou, Jin-cai;Yu, Hai-tao;Zhang, Chun-jing. And the article was included in Advanced Materials Research (Durnten-Zurich, Switzerland) in 2011.COA of Formula: C36H62O8 This article mentions the following:

To study the underlying mechanism of 20 (S)-Ginsenoside-Rh2 and 20 (R)-Ginsenoside-Rh2 inducing apoptosis of human lung adenocarcinoma A549 cells. In this study, cell death rate and cell survival rate were obtained using Trypan blue staining cell viability assay, and transmission electron microscopy was used to detect cell apoptosis. Meanwhile, IkappaB phosphorylation expression was analyzed by western blotting. Results showed that after A549 cells were treated with 30 μg/mL 20(S)-Rh2 and 20(R)-Rh2 for 48h, cell death rate increased significantly compared with the control group (P<0.05), and nuclear condensation, fragmentation, karyopycnosis and apoptotic bodies were found under transmission electron microscope. There were no significant changes of IkappaB expression after treated with 20(S)-Rh2 and 20(R)-Rh2 (P>0.05). After treated with 20(R)-Rh2, p-IkappaB expression increased obviously between 4h-6h (P<0.05). After treated with 20(S)-Rh2, p-IkappaB expression increased obviously between 1h-2h (P<0.05), back to normal over time after 3h, increased significantly again between 4h-6h (P<0.05), which indicated the activation of IkappaB participated in A549 cell apoptosis induced by Rh2. These results demonstrated that 20(S)-Rh2 and 20(R)-Rh2 both have the functions of activating I-kappaB/NF-kappaB signaling pathway, thus promoting A549 cell apoptosis. In the experiment, the researchers used many compounds, for example, 20(R)-Ginsenoside Rh2 (cas: 112246-15-8COA of Formula: C36H62O8).

20(R)-Ginsenoside Rh2 (cas: 112246-15-8) belongs to tetrahydropyran derivatives. Tetrahydropyrans and furans principally constitute as a central motif in diverse medicinally privileged molecules. 2-(Arylmethylene)cyclopropylcarbinols could be converted to the corresponding tetrahydropyrans stereoselectively in the presence of Brønsted acids under mild conditions. A plausible Prins-type reaction mechanism has been proposed.COA of Formula: C36H62O8

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Minor saponins from the leaves of Panax ginseng C.A.Meyer was written by Chen, Yingjie;Xu, Suixu;Ma, Qifeng;Yao, Xinsheng;Ogihara, Yukio;Takeda, Tadahiro. And the article was included in Shenyang Yaoxueyuan Xuebao in 1987.COA of Formula: C36H62O8 This article mentions the following:

Five minor compounds isolated from the leaves of P. ginseng were characterized as 20(R)-protopanaxatriol, daucosterin, 3β,12β-dihydroxy-dammar-20(22),24-diene-3-O-β-D-glucopyranoside (I), 20(R)-protopanaxadiol-3-O-β-D-glucopyranoside (II), and ginsenoside Rh₂, resp., on the basis of spectral analyses and chem. evidence. The two new saponins, I and II, were named as ginsenoside Rh₃ and 20(R)-ginsenoside Rh₂. Nine other major saponins obtained simultaneously were identical with ginsenoside Rh₁, -Rg₃, -Rg₂, -Rg₁, -Re, -Rd, -Rc, -Rb₂ and Rb₁ resp. In the experiment, the researchers used many compounds, for example, 20(R)-Ginsenoside Rh2 (cas: 112246-15-8COA of Formula: C36H62O8).

20(R)-Ginsenoside Rh2 (cas: 112246-15-8) belongs to tetrahydropyran derivatives. Dihydropyrans and tetrahydropyrans are examples of cyclic ethers widespread in nature. There is large number of marine macrolide natural products that contain tetrahydropyran and tetrahydrofuran ring together. For instance, goniodomin A (actin targeting polyether), prorocentrolide (toxin halistatins), and percentotoxineCOA of Formula: C36H62O8

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics