With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1152567-60-6,4-(4-Bromophenyl)tetrahydro-2H-pyran-4-carboxylic acid,as a common compound, the synthetic route is as follows.
1.34 g (4.70 mmol) of the compound from Example 72A/step 1 were stirred in 6.5 ml of thionyl chloride under reflux for 2 h. The batch was then concentrated on a rotary evaporator, the residue was taken up in toluene and the mixture was concentrated again. The resulting residue was then stirred in a mixture of methylene chloride and pentane (1:2), the solid which remained was filtered off and the filtrate was freed from the solvent. The filtrate residue obtained was dried in vacuo. 1.49 g (>100% of th.) of the target compound were isolated, this being employed in subsequent stages without further purification.
1152567-60-6, As the paragraph descriping shows that 1152567-60-6 is playing an increasingly important role.
Reference£º
Patent; BAYER SCHERING PHARMA AKTIENGESELLSCHAFT; US2011/301122; (2011); A1;,
Tetrahydropyran – Wikipedia
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