Category: 125995-03-1

Simple exploration of 125995-03-1

125995-03-1, The synthetic route of 125995-03-1 has been constantly updated, and we look forward to future research findings.

125995-03-1, Atorvastatin lactone is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 17: (2R,4R)-1-[2-(4,6-Dihydroxytetrahydro-2-pyranyl)-ethyl]-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide (18) (synthesis from Atorvastatin).; [Show Image] The atorvastatin lactone (21.6 g, 0.04 mol) was dissolved in anhydrous methylene chloride (500 ml) and then cooled to – 78 C with help of dry ice. DIBAL (80 ml, 1M solution in toluene) was added dropwise at the same temperature and stirring continued for 1 hour. The mixture was then quenched with 10 % solution of Rochelle’s salt (100 ml) and allowed to warm to room temperature. After addition of further methylene chloride (300 ml) and water (200 ml) concentrated HCl (50 ml) was added. Organic phase was separated and water phase was extracted with methylene chloride (2 x 200 ml). The combined organic phases were washed with 1 M HCl solution (2 ¡Á 100 ml), saturated NaHCO3 solution (2 ¡Á 100 ml) and brine (100 ml) and dried over anhydrous Na2SO4. Solvent was removed under reduced pressure to yield 20.6 g (95 %) of pure lactol 18. LC-MS (ESI+) m/z 543 (M+1), 507,414,388.

125995-03-1, The synthetic route of 125995-03-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Ratiopharm GmbH; EP1834944; (2007); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

Some tips on 125995-03-1

125995-03-1, The synthetic route of 125995-03-1 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.125995-03-1,Atorvastatin lactone,as a common compound, the synthetic route is as follows.

[R-(R*,R*)]-2-(4-fluorophenyl)-beta , delta -dihydroxy-5-(l-methylethyl )-3- phenyl-4-[(phenylamino)carbonyl]-lH-pyrrole-l-heptanoic acid potassium<68> lOOg of atorvastatin lacton was dissolved to 1 L of acetone and 10.38g of potassium hydroxide dissolved in 100 mL of water was added thereto over 1 hour. The reaction solution was stirred for 8 hours at room temperature, the solvent was completely removed by a distillation under reduced pressure, and the residue was distilled under vacuum, suspended to 500 mL of acetone, and filtered. The filtrate was dried for 24 hours at a temperature of 60 C to obtain 95g pf atorvastatin potassium.

125995-03-1, The synthetic route of 125995-03-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTECH CO., LTD.; WO2009/54682; (2009); A2;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

New learning discoveries about 125995-03-1

125995-03-1 Atorvastatin lactone 6483036, aTetrahydropyrans compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.125995-03-1,Atorvastatin lactone,as a common compound, the synthetic route is as follows.

50.0 g of atorvastatin lactone was suspended in a mixture of 150 a of t-butyl methyl ether and 100 ml of acetone, and 3.7 g of strontium hydroxide dissolved in 200 ml of water was slowly added thereto over 30 minutes, and stirred at room temperature for 3 hours. After removing the organic layer, 150 ml of t-butyl methyl ether was added to the aqueous layer, followed by stirring at room temperature for 10 minutes. The organic layer was again removed, and 200 ml of acetone was added to the aqueous layer. The mixture was warmed to 50 C., to which 10.2 g of strontium acetate dissolved in 250 ml of water was slowly added over 2 hours, stirred at 50 C. for 8 hours, and the resulting solution was cooled to room temperature. The precipitate formed was filtered, washed with a mixture of 60 ml of acetone and 90 ml of water and dried in air, to obtain 50.7 g of the title compound (yield: 85%) as a white crystalline powder.Moisture content (Karl-Fisher titrator): about 6.9%Based on the result of such moisture content analysis, the crystalline powder obtained above was confirmed to be the pentahydrate form of formula (Ia), and its XRPD result showed that it is a crystal having distinctively characteristic main peaks (those having I/Io of at least 10%), as shown in Table 1. Accordingly, the crystalline powder obtained above is designated Form I.

125995-03-1 Atorvastatin lactone 6483036, aTetrahydropyrans compound, is more and more widely used in various.

Reference£º
Patent; HANMI PHARM. CO., LTD.; US2010/120888; (2010); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

Downstream synthetic route of 125995-03-1

125995-03-1 Atorvastatin lactone 6483036, aTetrahydropyrans compound, is more and more widely used in various.

125995-03-1, Atorvastatin lactone is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 42 (100 mg, 185 muiotaetaomicron) was dissolved (0514) in ammonia (7Nin MeOH, 1.32 mL, 6.18 mmol) and the (0515) solution was stirred at rt for 24 h. The mixture was (0516) concentrated under reduced pressure. Purification by (0517) flash chromatography (CH2Cl2:MeOH = 95:5? 90: 10) (0518) afforded 43 as a white foam (73 mg, 71%). NMR (0519) (400 MHz, CDCls) delta 7.24-6.95 (m, 14H), 6.88 (br s, 1H), 5.73 (br s, 1H), 5.44 (br s, 1H), 4.42 (br s, 1H), 4.20-4.05 (m, 2H), 4.01-3.90 (m, 1H), 3.79-3.71 (m, 1H), 3.63-3.48 (m, 2H), 2.34-2.23 (m, 2H), 1.74-1.41 (m, 9H), 1.28-1.14 (m, 1H).

125995-03-1 Atorvastatin lactone 6483036, aTetrahydropyrans compound, is more and more widely used in various.

Reference£º
Patent; STICHTING KATHOLIEKE UNIVERSITEIT; SCHIRRIS, Tom Johan Joseph; RITSCHEL, Tina; RUTJES, Floris Petrus Johannes Theodorus; SMEITINK, Johannes Albertus Maria; RUSSEL, Francois Gerard Marie; (92 pag.)WO2017/137469; (2017); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics