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Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.HPLC of Formula: C7H10O4, you can also check out more blogs about127956-11-0

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.127956-11-0, Name is Methyl 4-oxotetrahydro-2H-pyran-3-carboxylate, molecular formula is C7H10O4. In a Patent£¬once mentioned of 127956-11-0, HPLC of Formula: C7H10O4

DIHYDROPYRANOPYRIMIDINES FOR THE TREATMENT OF VIRAL INFECTIONS

This invention relates to dihydropyranopynmidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.HPLC of Formula: C7H10O4, you can also check out more blogs about127956-11-0

Reference£º
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

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In an article, published in an article, once mentioned the application of 127956-11-0, Name is Methyl 4-oxotetrahydro-2H-pyran-3-carboxylate,molecular formula is C7H10O4, is a conventional compound. this article was the specific content is as follows.Computed Properties of C7H10O4

Rh2(II)-catalyzed ester migration to afford 3 H-indoles from trisubstituted styryl azides

Rh2(II)-Complexes trigger the formation of 3H-indoles from ortho-alkenyl substituted aryl azides. This reaction occurs through a 4pi-electron-5-atom electrocyclization of the rhodium N-aryl nitrene followed by a [1,2]-migration to afford only 3H-indoles. The selectivity of the migration is dependent on the identity of the beta-styryl substituent.

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Tetrahydropyran – Wikipedia,
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A new application about Methyl 4-oxotetrahydro-2H-pyran-3-carboxylate

Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 127956-11-0 is helpful to your research. 127956-11-0

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology.127956-11-0, Name is Methyl 4-oxotetrahydro-2H-pyran-3-carboxylate, molecular formula is C7H10O4, introducing its new discovery., 127956-11-0

Efficient synthesis of 3 H-indoles enabled by the lead-mediated alpha-arylation of beta-ketoesters or gamma-lactams using aryl azides

The development of a lead-mediated alpha-arylation reaction between aryl azides and beta-ketoesters or gamma-lactams that facilitates the formation of 3H-indoles is disclosed. Twenty-five examples are included which demonstrate the generality of this reaction to access aryl azides bearing tetrasubstituted o-alkyl substituents. When paired with a Staudinger reduction, this reaction streamlines the synthesis of functionalized 3H-indoles.

Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 127956-11-0 is helpful to your research. 127956-11-0

Reference£º
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

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127956-11-0, The synthetic route of 127956-11-0 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.127956-11-0,Methyl 4-oxotetrahydro-2H-pyran-3-carboxylate,as a common compound, the synthetic route is as follows.

To a solution of methyl 4-oxooxane-3-carboxylate (550 mg, 3.480 mmol, 1.00 equiv) in diethyl ether (20 ml_) at 0 C was added sodium hydride (208 mg, 5.200 mmol, 1.50 equiv, 60%) and the mixture was stirred at 15 C for 1 h. T riflic anhydride (1.50 g, 5.320 mmol, 1.53 equiv) was then added and resulting mixture was stirred overnight at 15 C. The reaction was quenched by the addition of water and the resulting solution was extracted with ethyl acetate (3 x 10 ml_) and the organic layers combined and dried over anhydrous sodium sulfate and concentrated under vacuum to yield methyl 4- [(trifluoromethane)sulfonyloxy]-5,6-dihydro-2H-pyran-3-carboxylate as yellow oil.

127956-11-0, The synthetic route of 127956-11-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; JANSSEN PHARMACEUTICA NV; LANTER, James C.; WALL, Mark; SUI, Zhihua; (0 pag.)WO2019/171278; (2019); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

Brief introduction of 127956-11-0

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127956-11-0, Methyl 4-oxotetrahydro-2H-pyran-3-carboxylate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate 49: 2-(1-Chloroethyl)-7,8-dihydro-3H-pyrano[4,3-d]pyrimidin-4(5H)-oneA mixture of methyl 4-oxotetrahydro-2H-pyran-3-carboxylate (1.0 g, 6.3 mmol), 2- chloropropanimidamide hydrochloride (0.9 g, 6.3 mmol), and triethylamine (3.52 ml_, 25.4 mmol) was stirred at ambient temperature for 24 h. The mixture was concentrated in vacuo to give the title compound (1 .4 g), which was used directly to the next step without further purification. MS m/z 215.2 (M+1 ), retention time = 1.27 min., 127956-11-0

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Reference£º
Patent; NOVARTIS AG; CHEN, Zhuoliang; CHEUNG, Atwood, Kim; CHIN, Donovan, Noel; FAN, Jianmei; MILLER-MOSLIN, Karen, Marie; SHULTZ, Michael, David; SMITH, Troy, D.; TOMLINSON, Ronald, Charles; TOURE, Bakary-Barry; VISSER, Michael, Scott; WO2013/12723; (2013); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

Downstream synthetic route of 127956-11-0

127956-11-0, 127956-11-0 Methyl 4-oxotetrahydro-2H-pyran-3-carboxylate 14666555, aTetrahydropyrans compound, is more and more widely used in various fields.

127956-11-0, Methyl 4-oxotetrahydro-2H-pyran-3-carboxylate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 2 (1.58 g, 10 mmol) and ammonium acetate (2.3 g, 30 mmol) in of MeOH (20 mL) was stirred overnight at room temperature. The mixture was concentrated under vacuum, dichloromethane (100 mL) and water (20 mL) were added, and the separated organic layer was dried over sodium sulfate and concentrated in vacuo. The crude product 3 was dissolved in 20 mL of CH3CN and treated with 2,2,2-trichloro-acetyl isocyanate (3.76 g, 20 mmol) and the mixture was stirred for 30 minutes. The resulting solid was collected by filtration and dissolved in NH3 in MeOH (8 mL, 7 N), the mixture was heated at 70C. After cooling to room temperature, a solid formed and was collected by filtration to give compound 4 (1.2 g, 71%). 1H NMR (300 MHz, DMSO-d6): delta 10.98 (br, 2H), 4.19 (s, 2H), 3.76 (t, J = 5.4 Hz, 2H), 2.38 (t, J = 5.4 Hz, 2H).

127956-11-0, 127956-11-0 Methyl 4-oxotetrahydro-2H-pyran-3-carboxylate 14666555, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; ZHOU, Han-Jie; PARLATI, Francesco; WUSTROW, David; WO2014/15291; (2014); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

Brief introduction of 127956-11-0

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127956-11-0, Methyl 4-oxotetrahydro-2H-pyran-3-carboxylate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To the mixture of 2-ethylisothiourea (9.07 g, 49.00 mmol, HBr salt) in H20 (50.00 mL) under dark was added Na2c03 (5.19 g, 49.00 mmol). Then to the mixture was added methyl 4-oxotetrahydro-2H-pyran-3-carboxylate (7.75 g, 49.00 mmol). The mixture was stirred under dark at 25 c for 16 h TLC (petroleum ether/EtOAc=1:1, Rf=0.3) showed one new main spot. The mixture was filtered, the solid was washed with water (30 mL), petroleum ether/EtOAc=20: 1 (20 mL). Then the solid was dried under reduced pressure to afford the title compound (8.01 g, crude) as an off-white solid. ?H NIVIR (400 MHz, DMSO-d6) oe 10.69 (s, 1H), 5.87 (s, 1H), 3.83 (s, 1H), 3.63-3.49 (m, 3H), 3.00-2.89 (m, 2H), 2.40 (s, 1H), 1.24 (t, J= 7.2 Hz, 3H).

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Reference£º
Patent; KADMON CORPORATION, LLC; OLSZEWSKI, Kellen; POYUROVSKY, Masha; BARSOTTI, Anthony; KIM, Ji-In; LIU, Kevin; MORRIS, Koi; (143 pag.)WO2016/210331; (2016); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

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127956-11-0 Methyl 4-oxotetrahydro-2H-pyran-3-carboxylate 14666555, aTetrahydropyrans compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.127956-11-0,Methyl 4-oxotetrahydro-2H-pyran-3-carboxylate,as a common compound, the synthetic route is as follows.

To a solution of intermediate 4 (2 g, 7.2 mmol) in ethanol (100 mL) methyl 4-oxotetrahydro-2H-pyran-3-carboxylate (2.4 g, 15 mmol, 2.1 eq.) and acetic acid (4.1 mL, 10 eq.) were added. The solution was stirred for 4 hours at reflux. The solution was then concentrated in vacuo and triturated in diisopropyl ether. The solid was filtered off and dried into the oven to give intermediate 48 (1.95 g, 72 %) as a white powder.LCMS mlz = 375 (M+H)1H NMR (400 MHz, DMSO-d6) oe ppm 1.30 – 1.38 (m, 2 H) 1.42 (s, 9 H) 1.48 – 1.63 (m, 2 H)1.64 – 1.77 (m, 1 H) 2.31 (d, J=13.64 Hz, 1 H) 2.69 (s, 2 H) 2.72 – 2.85 (m, 1 H) 3.79 – 3.96(m, 3 H) 4.44 (s, 2 H) 5.31 (br. s, 1 H) 5.77 (s, 1 H) 12.20 (s, 1 H), 127956-11-0

127956-11-0 Methyl 4-oxotetrahydro-2H-pyran-3-carboxylate 14666555, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; JANSSEN SCIENCES IRELAND UC; TAHRI, Abdellah; VENDEVILLE, Sandrine, Marie, Helene; JONCKERS, Tim, Hugo, Maria; RABOISSON, Pierre, Jean-Marie, Bernard; DEMIN, Samuel, Dominique; HU, Lili; (68 pag.)WO2016/91791; (2016); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.127956-11-0,Methyl 4-oxotetrahydro-2H-pyran-3-carboxylate,as a common compound, the synthetic route is as follows.

To a solution of the compound 1-1(4.75 g, 30.03 mmol) in MeOH(60 ml) was added NH4OAc(6.95 g, 90.10 mmol). After stirring for 3 h at rt, the reaction mixture was concentrated under reduced pressure and the residue was dissolved in DCM(300 ml). The resulting mixture was washed with water(75 ml), dried over Na2SO4, filtered, and concentrated under reduced pressure to afford the desired product 1-2(4.72 g) as a white solid.1H NMR (300 MHz, CDC13) 5 7.6 10 (brs, 1H), 6.856 (brs, 1H), 4.126 (s, 3H), 3.647 (t, J = 5.7 Hz, 2H), 3.538 (s, 3H), 2.249 (t, J = 5.7 Hz, 2H)., 127956-11-0

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Reference£º
Patent; ST PHARM CO., LTD.; KIM, Kyungjin; KIM, Uk-Il; YOON, Ji Hye; (32 pag.)WO2017/99424; (2017); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

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127956-11-0 Methyl 4-oxotetrahydro-2H-pyran-3-carboxylate 14666555, aTetrahydropyrans compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.127956-11-0,Methyl 4-oxotetrahydro-2H-pyran-3-carboxylate,as a common compound, the synthetic route is as follows.

The pyranone-2-carboxylic acid methyl ester was first poured into the autoclave and the temperature was lowered to -78C.The temperature was added with hydrogen fluoride and sulfur tetrafluoride, the molar ratio of beta-keto acid ester and SF4 and HF was 1:3:18, and the temperature was raised to 100C. The reaction was carried out for 24 hours to obtain the intermediate 1,1-difluoro-2-pyrancarboxylic acid. Methyl esters.The reaction solution was diluted with water and then extracted with ethyl acetate.The aqueous phase was washed twice with saturated sodium bicarbonate solution and the organic phase was dried and spin-dried to give the intermediate 1,1-difluoro-2-pyrancarboxylic acid methyl ester., 127956-11-0

127956-11-0 Methyl 4-oxotetrahydro-2H-pyran-3-carboxylate 14666555, aTetrahydropyrans compound, is more and more widely used in various.

Reference£º
Patent; Wuhan Yao Ming Kant, Immanuel New Drug Development Co., Ltd.; He Xin; Wu Rongfu; Liu Zhouya; Ma Jianyi; Zhang Zhiliu; Jiang Luyong; Ma Rujian; (6 pag.)CN107903205; (2018); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics