Category: 130290-79-8

130290-79-8, (Tetrahydro-2H-pyran-4-yl)methanamine is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-chloro-3-nitrobenzene-1-sulfonamide (100 g), 4-cyano-tetrahydropyran(97.4 mL), and N,N- diisopropylethylamine (160 mL)were heated in acetonitrile to 70C for 24 hours. After coolingto 55 C,t he reaction mixture was distilled at 55 C to remove s olvent until two reaction mass volumes remained. Water (800 mL) was added to the reaction and stirred 1 hour. The reaction mixture was filtered and the solid was washed with water (200 mL), followed by acetonitrile (300 mL) and ethyl acetate (300 mL). The solid was dried under vacuum at 55C for 4 hours. (60g, Yield: 0.6w/w)., 130290-79-8

130290-79-8 (Tetrahydro-2H-pyran-4-yl)methanamine 2773210, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; MYLAN LABORATORIES LIMITED; JOSHI, Rajesh; TRIPATHI, Anil Kumar; CHAUDHARI, Chandrakant; GOTTUMUKKALA, Nagaraju; POKHARKAR, Kiran; SANGVIKAR, Yogesh; VADALI, Lakshmanarao; JAYACHANDRA, Suresh Babu; (48 pag.)WO2018/29711; (2018); A2;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.130290-79-8,(Tetrahydro-2H-pyran-4-yl)methanamine,as a common compound, the synthetic route is as follows.,130290-79-8

A mixture of 4-fluoro-3-nitrobenzenesulfonamide (2.18 g), l-(tetrahydropyran-4- yl)methylamine (1.14 g), and triethylamine (1 g) in tetrahydrofuran (30 mL) were stirred overnight, neutralized with concentrated HC1 and concentrated. The residue was suspended in ethyl acetate and the precipitates were collected, washed with water and dried to provide the title compound.

As the paragraph descriping shows that 130290-79-8 is playing an increasingly important role.

Reference£º
Patent; ABBOTT LABORATORIES; CATRON, Nathaniel D.; CHEN, Shuang; GONG, Yuchuan; ZHANG, Geoff G.; WO2012/71336; (2012); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

130290-79-8, (Tetrahydro-2H-pyran-4-yl)methanamine is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-Fluoro-3-nitrobenzenesulfonamide (1.0 g, 4.54 mmol), (tetrahydro-2H-pyran-4-yl)methylamine (0.6 g, 4.49 mmol), Triethylamine (1.3 g, 6.81 mmol) was added to 10 ml of tetrahydrofuran solution. After stirring at room temperature for 5 h, the solvent was removed. Add 20ml of methanol to beat, After drying, the product was obtained in an amount of 1.4 g. The yield was 97%., 130290-79-8

130290-79-8 (Tetrahydro-2H-pyran-4-yl)methanamine 2773210, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; Shenzhen Tajirui Bio-pharmaceutical Co., Ltd.; Wang Yihan; Liu Zhiqiang; (35 pag.)CN108658983; (2018); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.130290-79-8,(Tetrahydro-2H-pyran-4-yl)methanamine,as a common compound, the synthetic route is as follows.

To a 500 mL three-neck RB flask equipped with a mechanical stirrer were charged the 4- chloro-3-nitrobenzenesulfonamide (23.7 g, 100 mmol), DIPEA (12.9 g, 100 mmol), (tetrahydro-2H-pyran-4-yl)methanamine( 11.5 g, 100 mmol) and acetonitrile (200 mL). The reaction mixture was adjusted to an internal temperature of 80 C and agitated for no less than 12 hours. The product solution was cooled down to 40 C and agitated for no less than 1 hour until precipitation observed. The product slurry was further cooled to 20 C. Water (80 mL) was slowly charged over no less than 1 hour, and the mixture cooled to 10 C and agitated for no less than 2 hours before collected by filtration. The wet cake was washed with 1:1 mix of acetonitrile:water (40 mL). The wet cake was rinsed with water (80 mL) at 40 C for no less than 1 hour before collected by filtration. The wet cake was rinsed with water (20 mL), and dried at 75 C under vacuum to give the 3 -nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide (24.5 g, 78%) as an orange solid. ?H NMR (400 MHz, DMSO) 8.60 (t, I = 5.9 Hz, 1H), 8.48 (d, I = 2.2 Hz, 1H), 7.84 (dd, I = 9.2, 2.0 Hz, 1H), 7.54-7.18 (m, 3H), 3.86 (dd, I = 11.3, 3.2 Hz, 2H), 3.35 (s, 2H), 3.27 (t, I = 10.9 Hz, 2H), 1.92 (ddd, I = 11.2, 7.4, 3.9 Hz, 1H), 1.62 (d, I =11.4 Hz, 2H), 1.27 (qd, I = 12.3, 4.4 Hz, 2H)., 130290-79-8

The synthetic route of 130290-79-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NEWAVE PHARMACEUTICAL INC.; CHEN, Yi; LOU, Yan; (108 pag.)WO2019/40550; (2019); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics