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Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter. 135643-82-2, Name is Methyl 2-((tetrahydro-2H-pyran-2-yl)oxy)acetate, molecular formula is C8H14O4. In a Article,once mentioned of 135643-82-2, Computed Properties of C8H14O4

Syntheses of 5′-acyl furanosteroids are described from the corresponding unsubstituted [3,2-b]furanosteroids using acid anhydrides and acid chlorides in the presence or absence of Lewis acids. New methods have been developed to prepare 5′-acetyl derivatives: reduction of a 5′-trichloroacetyl intermediate either by sodium formaldehyde sulfoxylate or with 10% Pd/C. Most of these 5′- acyl derivatives bind to the rat ventral prostate androgen receptor. However the antiandrogenic activity was diminished when compared with 4, 5′- methylsulfonyl furanosteroid. Biological studies revealed that 5′-acyl furanosteroids were either androgens or modest antiandrogens. The electrostatic potential maps of the substructures of 3, 4, and 5′-acetyl syn- and anti-furanosteroids showed striking differences which may explain, to some extent, the lack of significant antiandrogenic activity of 5′-acyl furanosteroids.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Awesome Chemistry Experiments For 135643-82-2

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Computed Properties of C8H14O4, you can also check out more blogs about135643-82-2

Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter. 135643-82-2, Name is Methyl 2-((tetrahydro-2H-pyran-2-yl)oxy)acetate, molecular formula is C8H14O4. In a Article,once mentioned of 135643-82-2, Computed Properties of C8H14O4

Syntheses of 5′-acyl furanosteroids are described from the corresponding unsubstituted [3,2-b]furanosteroids using acid anhydrides and acid chlorides in the presence or absence of Lewis acids. New methods have been developed to prepare 5′-acetyl derivatives: reduction of a 5′-trichloroacetyl intermediate either by sodium formaldehyde sulfoxylate or with 10% Pd/C. Most of these 5′- acyl derivatives bind to the rat ventral prostate androgen receptor. However the antiandrogenic activity was diminished when compared with 4, 5′- methylsulfonyl furanosteroid. Biological studies revealed that 5′-acyl furanosteroids were either androgens or modest antiandrogens. The electrostatic potential maps of the substructures of 3, 4, and 5′-acetyl syn- and anti-furanosteroids showed striking differences which may explain, to some extent, the lack of significant antiandrogenic activity of 5′-acyl furanosteroids.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

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While the job of a research scientist varies, most chemistry careers in research are based in laboratories, where research is conducted by teams following scientific methods and standards. 135643-82-2, Name is Methyl 2-((tetrahydro-2H-pyran-2-yl)oxy)acetate, molecular formula is C8H14O4. In a Article,once mentioned of 135643-82-2, Application In Synthesis of Methyl 2-((tetrahydro-2H-pyran-2-yl)oxy)acetate

(Chemical Equation Presented) Intramolecular ene reactions of simple alkenyl aldehydes are catalyzed by a chiral (Schiff base)CrIII complex with high enantio-and diastereoselectivity, affording densely functionalized heterocyclic or carbocyclic products (see scheme for example). Desymmetrizations of alkenyl dialdehydes and bis(alkenyl) aldehydes are also achieved.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

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The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.135643-82-2, Name is Methyl 2-((tetrahydro-2H-pyran-2-yl)oxy)acetate, molecular formula is C8H14O4. In a Article,once mentioned of 135643-82-2, HPLC of Formula: C8H14O4

A mild, general, and efficient method for the synthesis of 2-monosubstituted and 2,5-disubstituted furans via the CuI-catalyzed cycloisomerization of alkynyl ketones was developed. It was demonstrated that furans containing both acid- and base-labile groups could be easily synthesized using this methodology. A plausible mechanism for this transformation is proposed.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

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The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 135643-82-2 is helpful to your research., Related Products of 135643-82-2

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Antiandrogenic sulfonylsteroidofurans

5”-Alkylsulfonylsteroido[3,2-b]furans, for example 5”-methylsulfonyl-5alpha-pregn-2-en-20-yno[3,2-b]furan-17beta-ol having the structural formula, STR1 which are useful as antiandrogenic agents, and processes for preparation, method of use and compositions thereof are disclosed.

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Reference:
Tetrahydropyran – Wikipedia,
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The first total synthesis of the boron-containing macrodiolide antibiotic tartrolon B is reported in full detail. Two convergent approaches to the target compound are described, the first of which eventually failed, due to sensitive functionality. In the second, successful route the key step was a stereoselective boron-mediated aldol addition of a bicyclic acetonide protected ketone to a dienealdehyde. In this case the synthesis could be completed without major problems, using a Yamaguchi dimerization macrolactonization endgame.

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Reference£º
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

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The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.135643-82-2, Name is Methyl 2-((tetrahydro-2H-pyran-2-yl)oxy)acetate, molecular formula is C8H14O4. In a Article£¬once mentioned of 135643-82-2, Safety of Methyl 2-((tetrahydro-2H-pyran-2-yl)oxy)acetate

Androgen receptor affinity of 5′-acyl furanosteroids

Syntheses of 5′-acyl furanosteroids are described from the corresponding unsubstituted [3,2-b]furanosteroids using acid anhydrides and acid chlorides in the presence or absence of Lewis acids. New methods have been developed to prepare 5′-acetyl derivatives: reduction of a 5′-trichloroacetyl intermediate either by sodium formaldehyde sulfoxylate or with 10% Pd/C. Most of these 5′- acyl derivatives bind to the rat ventral prostate androgen receptor. However the antiandrogenic activity was diminished when compared with 4, 5′- methylsulfonyl furanosteroid. Biological studies revealed that 5′-acyl furanosteroids were either androgens or modest antiandrogens. The electrostatic potential maps of the substructures of 3, 4, and 5′-acetyl syn- and anti-furanosteroids showed striking differences which may explain, to some extent, the lack of significant antiandrogenic activity of 5′-acyl furanosteroids.

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Reference£º
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

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Enantioselective catalytic carbonyl-ene cyclization reactions

(Chemical Equation Presented) Intramolecular ene reactions of simple alkenyl aldehydes are catalyzed by a chiral (Schiff base)CrIII complex with high enantio-and diastereoselectivity, affording densely functionalized heterocyclic or carbocyclic products (see scheme for example). Desymmetrizations of alkenyl dialdehydes and bis(alkenyl) aldehydes are also achieved.

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Reference£º
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.135643-82-2,Methyl 2-((tetrahydro-2H-pyran-2-yl)oxy)acetate,as a common compound, the synthetic route is as follows.

A. Under nitrogen with stirring at room temperature solution of 17beta-hydroxy-5alpha-androstan-3-one (the compound of Formula VII wherein X-Y is STR14 and Z is H, 145.2 g.) in dry dimethylformamide (500 ml.) was added slowly to a suspension of sodium hydride (60%, 48 g.) in dry dimethylformamide (100 ml.). A solution of methyl glycolate tetrahydropyranyl ether (130.5 g.) in dry dimethylformamide (100 ml.) was then slowly added. After continued stirring overnight methanol (50 ml.) was added slowly. The resulting mixture was poured into ice-water (4 1.). The resulting solution was filtered and the filter pad was washed with water. Neutralization of the filtrate with hydrochloric acid (6N) gave a white crystalline solid, which was collected by filtration, washed with water and dried, affording 17beta-hydroxy-2alpha-{[(tetrahydro-2H-pyran-2-yl)oxy]acetyl}-5alpha-androstan-3-one (the compound of Formula VI wherein Q’ is tetrahydropyranyl, X-Y is STR15 and Z is H; 206 g, 96% yield). Recrystallization of part (15.0 g.) of the product from cyclohexane gave a white crystalline solid (12.0 g.) having m.r. 128-131 C.

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Reference£º
Patent; Sterling Drug Inc.; US5100882; (1992); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics