Category: 1408168-76-2

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1408168-76-2,Potassium trifluoro(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)borate,as a common compound, the synthetic route is as follows.

To a stirred solution of 2,3-dibromo-6-methoxypyridine, Step 1 : Example 31 , (1.4 g, 5.30 mmol), potassium trifluoro(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)borate, Step 3: Example 31 , (3.7 g, 15.90 mmol) and cataCXiumA (0.35 g, 1.06 mmol) in dry 1 ,4 dioxane (12 mL), was added a solution of cesium carbonate (1.62 g, 31.80 mmol) in water (4 mL) at RT. The reaction mixture was degassed for 10 min using N2 gas. Then Pd(OAc)2 (0.33 g, 1.59 mmol) was added at RT and the reaction mixture was heated to 100 ? for 20 h. Completion of the reaction was monitored by TLC. After completion, the reaction mixture was diluted with EtOAc (10mL) and brine (10mL) and the aqueous layer was extracted with EtOAc (2 x 20 mL), washed with water (10 mL), brine (10 ml_), dried over Na2SC>4 and concentrated under reduced pressure. The resulting crude material was purified by flash chromatography using 12-15% EtOAc in petroleum ether to afford the tittle compound. Yield: 57% (1.1 g, brown gummy solid). 1H NMR (400 MHz, CDCI3): d 7.40 (d, J = 8.4 Hz, 1 H), 6.53 (d, J = 8.0 Hz, 1 H), 4.62 (d, J = 20.8 Hz, 2H), 4.20-4.11 (m, 1 H), 3.95-3.89 (m, 2H), 3.88 (s, 3H), 3.81 – 3.70 (m, 2H), 3.61-3.51 (m, 1 H), 3.50-3.46 (m, 2H), 3.07 (t, J = 7.2 Hz, 2H), 2.91 (t, J = 7.2 Hz, 2H), 1.81 (t, J = 8.4 Hz, 2H), 1.71 (t, J = 10.0 Hz, 2H), 1.62-1 .59 (m, 8H). LCMS: (Method A) 366.2 (M+H), 1.7 min, 90.1 % (Max)., 1408168-76-2

1408168-76-2 Potassium trifluoro(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)borate 74787645, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; ASCENEURON S. A.; QUATTROPANI, Anna; WISHART, Grant; KULKARNI, Santosh S.; GIRI, Awadut Gajendra; RAKESH, Paul; (250 pag.)WO2020/39028; (2020); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

1408168-76-2, Potassium trifluoro(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)borate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A schlenk flask was charged with the compound obtained in example 1 (0.56 g, 1.3 mmol), bis(di-fe/f-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(ll) (94 mg, 0.13 mmol), potassium trifluoro(2-((tetrahydro-2/-/-pyran-2-yl)oxy)ethyl)borate (0.34 g, 1.6 mmol), and CS2CO3 (1.7 g, 5.3 mmol) and it was evacuated and backfilled with argon. Tolueneil-hO (4:1 , 10 mL) was added and the reaction mixture was heated at 100 C overnight. H2O was added and the product was extracted with EtOAc. The combined organic layers were dried over Na2S04, filtered and concentrated to dryness to give the title compound (0.62 g, Yield: 99%)., 1408168-76-2

1408168-76-2 Potassium trifluoro(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)borate 74787645, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; ESTEVE PHARMACEUTICALS, S.A.; FERNANDEZ-DONIS, Ariadna; DIAZ-FERNANDEZ, Jose, Luis; ALMANSA-ROSALES, Carmen; LORENTE-CRIVILLE, Adriana; (0 pag.)WO2020/89400; (2020); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics