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The selective and efficient production of N-acetyl-D-glucosamine (GlcNAc) was achieved from flake type of alpha-chitin by using crude enzymes derived from Aeromonas hydrophila H-2330.

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Tetrahydropyran – Wikipedia,
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N-protected 2-amino-2-deoxy-D-glycopyranoses can be selectively halogenated on C-6 by treatment with triphenylphosphine-carbone tetrahalide-pyridine.

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The synthesis of the first glycosylidene-derived 2-acetamido-2-deoxydiazirine 4 from N-acetylglucosamine 6 is described.Thus, 6 was transformed into the 3-O-mesylglucopyranoside 9 by glycosidation with allyl alcohol, benzylidenation, and mesylation (Scheme 2).Solvolysis of 9 gave the allopyranoside 10 which, upon benzylation and glycoside cleavage, yielded the hemiacetals 12.Using our established method (via the lacton oxime 14 and the diaziridines 16), 12 gave the diazirine 4.Thermolysis of this diazirine in the presence of i-PrOH gave the dihydro-1,3-oxazole 5 (Scheme 1); in the presence of acrylonitrile, the four diastereomeric spirocyclopropanes 17-20 and the acetamidoallal 21 were obtained and separated by prep.HPLC (Scheme 3).Assignment of the configuration of 17-20 is based on NOE measurements and on the effect of diamagnetic anisotropy of the CN group.The ratio of the four cyclopropanes, which is in keeping with earlier results, is rationalized.

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Galacto-N-biose (GNB) derivatives were efficiently synthesized from galactose derivatives via a one-pot two-enzyme system containing two promiscuous enzymes from Bifidobacterium infantis: a galactokinase (BiGalK) and a d-galactosyl-beta1-3-N-acetyl-d-hexosamine phosphorylase (BiGalHexNAcP). Mono-sialyl and di-sialyl galacto-N-biose derivatives were then prepared using a one-pot two-enzyme system containing a CMP-sialic acid synthetase and an alpha2-3-sialyltransferase or an alpha2-6-sialyltransferase.

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2-Acetamido-1,2,4-trideoxy-1,4-imino-D-galactitol was synthesised from 2-acetamido-2-deoxy-D-glucose in 12 steps and was shown to be a modest hexosaminidase inhibitor.

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Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps. 14215-68-0, Name is N-((2S,3R,4R,5R,6R)-2,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)acetamide, molecular formula is C8H15NO6. In a Patent,once mentioned of 14215-68-0, Product Details of 14215-68-0

A drug delivery vehicle comprising a vesicle conjugated to one or more targeting groups, wherein the targeting groups comprise an oligosaccharide which is Lewis A or Lewis B or a mimetic thereof, or a pharmaceutically acceptable salt or PEGylated form of the oligosaccharide : (I) wherein R represents the pointof attachment to the vesicle.10

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The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. 14215-68-0, Name is N-((2S,3R,4R,5R,6R)-2,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)acetamide, molecular formula is C8H15NO6. In a Article,once mentioned of 14215-68-0, name: N-((2S,3R,4R,5R,6R)-2,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)acetamide

Analogs of vancomycin and pseudo-vancomycin with new sugar attachments in mono- and di-saccharide form have been enzymatically synthesized by glycosylation with overexpressed glycosyltransferases, beta1,4- galactosyltransferase and alpha2,3-sialyl transferases. All four analogs, including galactose-containing derivatives (6 and 8) and galactose- and sialic acid-containing derivatives (7 and 9) were prepared and characterized by HPLC, LC-MS, NMR and MIC test.

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beta-Gal-3 ATCC 31382 (beta-Gal-3) was immobilized by multipoint covalent attachment on an agarose support using different enzyme orientations on its surface. The derivatives that showed more activity and stability were the ones bound to a Lys rich region on a monofunctional glyoxyl-agarose (GA) support. Also, immobilization was performed using a Glu + Asp rich region on a heterofunctional amino-glyoxyl-agarose (AMGA) support. The immobilized enzyme was characterized in terms of optimal pH and thermal stability, and its catalytic efficiency was tested on the synthesis of beta-(1?3) galactosyldisaccharides. Reactions were performed in the presence of green solvents ([Bmim][PF6] and 2HNND) with maximum conversion and maintained regioselectivity. Reusability assays under identical reaction conditions were also performed to find that GA immobilized enzyme retains about 90% of its activity after six batches with conversion yields above 75% when [Bmin][PF6] was used as reaction media. Furthermore, green solvent recovery and recycling are achieved retaining catalytic activity and increased productivity.

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The transformation of simple hydrocarbons into more complex and valuable products has revolutionised modern synthetic chemistry. This type of reactivity has quickly become one of the cornerstones of modern catalysis . 14215-68-0, Name is N-((2S,3R,4R,5R,6R)-2,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)acetamide, molecular formula is C8H15NO6. In a Patent,once mentioned of 14215-68-0, name: N-((2S,3R,4R,5R,6R)-2,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)acetamide

The invention provides non-glucocerebroside dihydrochalcone, which is characterized by being a compound with the following general formula I, or an acceptable salt formed by the non-glucocerebroside dihydrochalcone as a compound with the general formula I and an inorganic or organic acid. and the non-glucocerebroside dihydrochalcone is an acceptable salt formed from a compound of the general formula I and an inorganic acid or an organic acid. Wherein. In the formula I, A comprises any one of a di-glycosyl, a monosaccharide group; the substituent group of R represents acurrcurrcurrcurry a alkyl, halogen-substituted acurrcurrcurrcurry a alkyl, 1-4 ?-membered alkenyl, 1-4 ?-membered alkynyl, 3 – 4 3 – 6-membered cycloalkyl, and halogen-substituted 3 – 6 3 – 4-membered cycloalkyl. The non-glucocerebroside dihydrochalcone provided by the embodiment of the invention can accelerate the onset time of hypoglycemic at low toxic and side effects, and effectively improve the sugar tolerance. (by machine translation)

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Tetrahydropyran – Wikipedia,
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A simple, mild and efficient solvent-free method for the acetylation of carbohydrates, and their partially protected derivatives, as well as non-carbohydrate substances in excellent yields in the presence of 1,4-diazabicyclo[2.2.2]octane (DABCO) is described with the advantage of tolerance to various functional groups, short reaction time and ease of product isolation.

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Reference:
Tetrahydropyran – Wikipedia,
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