New learning discoveries about 19752-84-2

The synthetic route of 19752-84-2 has been constantly updated, and we look forward to future research findings.

19752-84-2,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19752-84-2,Tetrahydro-2H-pyran-3-ol,as a common compound, the synthetic route is as follows.

Compound 2 (300 g, 2.9 mol) was dissolved in 3000 g of dichloromethane and sodium acetate (287 g, 3.5 mol) was added.TEMPO 6g, add sodium dichloroisocyanurate (374g, 1.7mol) in batch at 25C, maintain the reaction at 25C for 2h, filter,The organic phase was dried with 200g of anhydrous sodium sulfate, filtered and concentrated in a water pump and distilled to collect the oil temperature of 120C and the top temperature of 90C.250 g of a colorless oily liquid having a purity of 99% and a yield of 83%.

The synthetic route of 19752-84-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Haimen Huaxiang Pharmaceutical Technology Co., Ltd.; Yong Dawei; Cao Zhong; Yang Shaoqiang; Lu Yi; Zhou Guang; Xu Benquan; (4 pag.)CN107382928; (2017); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

Downstream synthetic route of 19752-84-2

The synthetic route of 19752-84-2 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19752-84-2,Tetrahydro-2H-pyran-3-ol,as a common compound, the synthetic route is as follows.

To a mixture of oxalyl chloride (2.28 mL, 26.6 mmol) and dichloromethane (40 mL) was added a mixture of DMSO (3.78 mL, 53.2 mmol) and dichloromethane (20 mL) while stirring at -78 C., and the mixture was stirred at -78 C. for 30 minutes. After then adding to this mixture a mixture of tetrahydropyran-3-ol (synthesised according to the method described in Tetrahedron, 60, 10411-10418, 2004) (1.36 g, 13.3 mmol) and dichloromethane (20 mL) at -78 C., the resulting mixture was stirred at -78 C. for 30 minutes, after which triethylamine (11.1 mL, 79.8 mmol) was added and stirring was continued for 2 hours while slowly raising the temperature to 0 C. Brine and diethyl ether were added to the mixture, and after sufficient shaking, the organic layer was separated and the organic layer was washed with brine and dried over anhydrous magnesium sulfate. The mixture was then filtered, and the solvent in the filtrate was distilled off under reduced pressure to obtain the title compound (1.62 g, 16.2 mmol). 1H-NMR(CDCl3) delta: 2.07-2.14 (m, 2H), 2.54 (t, J=6.8 Hz, 2H), 3.82-3.88 (m, 2H), 4.03 (s, 2H).

The synthetic route of 19752-84-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Eisai R & D Management Co., Ltd.; US2009/259049; (2009); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

New learning discoveries about 19752-84-2

The synthetic route of 19752-84-2 has been constantly updated, and we look forward to future research findings.

19752-84-2, Tetrahydro-2H-pyran-3-ol is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 2 (300 g, 2.9 mol) was dissolved in 3000 g of dichloromethane and sodium acetate (287 g, 3.5 mol) was added.TEMPO 6g, add sodium dichloroisocyanurate (374g, 1.7mol) in batch at 25C, maintain the reaction at 25C for 2h, filter,The organic phase was dried with 200g of anhydrous sodium sulfate, filtered and concentrated in a water pump and distilled to collect the oil temperature of 120C and the top temperature of 90C.250 g of a colorless oily liquid having a purity of 99% and a yield of 83%.

The synthetic route of 19752-84-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Haimen Huaxiang Pharmaceutical Technology Co., Ltd.; Yong Dawei; Cao Zhong; Yang Shaoqiang; Lu Yi; Zhou Guang; Xu Benquan; (4 pag.)CN107382928; (2017); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics