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There are provided compounds of the formula and pharmaceutically acceptable salts and esters thereof wherein W, V, X, Y, A, R and R’ are as described herein. The compounds are useful as anticancer agents.

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Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter. 2081-44-9, Name is Tetrahydro-2H-pyran-4-ol, molecular formula is C5H10O2. In a Patent,once mentioned of 2081-44-9, Related Products of 2081-44-9

Compounds of formula (I’) and methods of their use and preparation, as well as compositions comprising compounds of formula (I’).

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Control of stem rust disease of wheat was investigated using different combinations of Trichoderma spp. and arbuscular mycorrhizal (AM) fungi. Impact of the application of T. harzianum HL1 and T. viride HL5, singly or in combination, on the uredospores germination of Puccinia graminis Pers. f. sp. tritici was assessed in vitro. The combined spore suspension of both isolates showed the superiority over the others in this regard. Observations of the scanning electron microscopy confirmed this result. Using a GC-MS system, the chemical constitution of the culture filtrates of T. harzianum HL1 and T. viride HL5 was identified. Under the greenhouse conditions, application of AM fungi and Trichoderma spp. significantly reduced the disease measures, induced the peroxidase and polyphenol oxidase enzymes, increased the total phenol content and improved the tested growth and yield parameters. Based on their efficiency and eco-safety, we can recommend the use of this combination in controlling stem rust disease of wheat.

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Derivatives of (2-amidino-1,2,3,4-tetrahydro-isoquinolin-7- yloxy)phenylacetic acid (TIPAC) were developed as inhibitors of factor Xa (fXa). The compounds are prepared using 15 synthetic steps on average. The most potent compounds (14, 17, 22-26) display inhibition constants of K(i) = 21-55 nM but do not inhibit thrombin (K(i) = 5-> 100 muM) and only weakly inhibit trypsin (K(i) = 0.08-5 muM). They bear a second basic moiety, e.g., substituted 1-(iminomethyl)piperidines, which is linked to C-4 of the phenyl group of TIPAC via an oxygen atom. The inhibition constants of these compounds are almost independent of the size of the (iminomethyl)piperidine substituent. Due to the fact that fXa displays two cation binding sites, namely, the S1 and S4 sites, in principle two binding modes are conceivable for the novel dibasic fXa inhibitors. Molecular modeling experiments based on the X-ray structures of uninhibited fXa and the DX-9065a/fXa complex were carried out. The results taken together with the inhibition constants clearly favor one binding mode: the tetrahydro-isoquinoline fills the S1 pocket even better than the naphthalene moiety of DX-9065a, and the (iminomethyl)piperidine residues occupy the S4 site.

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The present invention is directed to saframcyin analogs that are useful in the treatment of cancer. Pharmaceutical compositions and processes for preparing these compounds are also disclosed.

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A novel class of biphenyl analogues containing a benzoic acid moiety based on lead compound 8i have been identified as potent and selective human beta3 adrenergic receptor (beta3-AR) agonists with good oral bioavailability and long plasma half-life. After further substituent effects were investigated at the terminal phenyl ring of lead compound 8i, we have discovered that more lipophilic substitution at the R position improved potency and selectivity. As a result of these studies, 10a and 10e were identified as the leading candidates with the best balance of potency, selectivity, and pharmacokinetic profiles. In addition, compounds 10a and 10e were evaluated to be efficacious for a carbachol-induced increase of intravesical pressure, such as an overactive bladder model in anesthetized dogs. This represents the first demonstrated result dealing with beta3- AR agonists.

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Reaction of fluorine with water in the presence of acids provides new oxidants for ‘in-situ’ oxidation of ketones. Direct reaction of fluorine with anhydrous alcohols and 1,2-diols provides simple methodology for oxidation to corresponding secondary ketones or alpha-hydroxy ketones.

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Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection with one or more small molecule compounds. Examples of paramyxovirus infection include an infec­tion caused by human respiratory syncytial virus (RSV).

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[Problem] to provide a compound having excellent anti-fungal activity of the Trichophyton. The general formula (I) [a][In the formula, the ring a may be substituted phenyl A, Q is CH2 Such; X1 , X2 X and3 The CR1 Such; Y is CH or N] biaryl derivative or a salt thereof represented by the pharmaceutical. [Drawing] no (by machine translation)

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The present disclosure relates to novel compounds HIF-2alpha inhibitors and pharmaceutical compositions thereof which may be useful in the treatment and/or prevention of various conditions. The present disclosure also provides methods of preparing such HIF-2alpha inhibitors and compositions, and methods of using the same.

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