Category: 27469-61-0

Related Products of 27469-61-0. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 1-(Bis(4-chlorophenyl)methyl)piperazine, is researched, Molecular C17H18Cl2N2, CAS is 27469-61-0, about Synthesis and Topical Antiinflammatory and Antiallergic Activities of Antioxidant o-Aminophenol Derivatives. Author is Sugiyama, Naoki; Akahoshi, Fumihiko; Kuwahara, Shigeki; Kajii, Masahiko; Sakaue, Yoshiko; Yakumaru, Haruko; Sugiura, Masanori; Fukaya, Chikara.

A series of o-aminophenol derivatives I, II, and III (R1, R2 = Ph, 4-ClC6H4, 4-FC6H4, R3 = H, Me, CHMe2, R4 = Me, CMe3, m, n = 2, 3) bearing H1-antihistaminic structures were prepared to develop novel compounds for topical use possessing antiallergic as well as antiinflammatory activities. The effects of I-III were investigated on lipid peroxidation in rat brain homogenates, antiinflammatory effect on arachidonic acid- and 12-O-tetradecanoylphorbol-13-acetate-induced mouse ear edema and antiallergic effect on 48-h homologous passive cutaneous anaphylaxis in rats. Furthermore, the effects of these compounds on delayed-type hypersensitivity reaction in mice were examined Several N-monosubstituted amino-4-methylphenols exert potent inhibitory activities in all of these assays. Of these compounds, I (R1 = R2= 4-FC6H4, R3 = H, R4 = Me, m = 3, n = 2) was chosen for further development as AD0261.

Here is just a brief introduction to this compound(27469-61-0)Related Products of 27469-61-0, more information about the compound(1-(Bis(4-chlorophenyl)methyl)piperazine) is in the article, you can click the link below.

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

SDS of cas: 27469-61-0. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 1-(Bis(4-chlorophenyl)methyl)piperazine, is researched, Molecular C17H18Cl2N2, CAS is 27469-61-0, about Evaluation of NHS Carbamates as a Potent and Selective Class of Endocannabinoid Hydrolase Inhibitors. Author is Niphakis, Micah J.; Cognetta, Armand B.; Chang, Jae Won; Buczynski, Matthew W.; Parsons, Loren H.; Byrne, Frederika; Burston, James J.; Chapman, Victoria; Cravatt, Benjamin F..

Monoacylglycerol lipase (MAGL) is a principal metabolic enzyme responsible for hydrolyzing the endogenous cannabinoid (endocannabinoid) 2-arachidonoylglycerol (2-AG). Selective inhibitors of MAGL offer valuable probes to further understand the enzyme’s function in biol. systems and may lead to drugs for treating a variety of diseases, including psychiatric disorders, neuroinflammation, and pain. N-Hydroxysuccinimidyl (NHS) carbamates have recently been identified as a promising class of serine hydrolase inhibitors that shows minimal cross-reactivity with other proteins in the proteome. Here, the authors explore NHS carbamates more broadly and demonstrate their potential as inhibitors of endocannabinoid hydrolases and addnl. enzymes from the serine hydrolase class. The authors extensively characterize an NHS carbamate MJN110 as a potent, selective, and in-vivo-active MAGL inhibitor. Finally, the authors demonstrate that MJN110 alleviates mech. allodynia in a rat model of diabetic neuropathy, marking NHS carbamates as a promising class of MAGL inhibitors.

Here is just a brief introduction to this compound(27469-61-0)SDS of cas: 27469-61-0, more information about the compound(1-(Bis(4-chlorophenyl)methyl)piperazine) is in the article, you can click the link below.

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 27469-61-0, is researched, SMILESS is ClC1=CC=C(C=C1)C(N2CCNCC2)C3=CC=C(Cl)C=C3, Molecular C17H18Cl2N2Preprint, ChemRxiv called Structure-activity relationships of glutathione peroxidase 4 inhibitor warheads, Author is Eaton, John K.; Furst, Laura; Cai, Luke L.; Viswanathan, Vasanthi S.; Schreiber, Stuart L., the main research direction is ML162 benzhydrylpiperazine propiolamide nitrile oxide synthesis SAR GPX4 ferroptosis.SDS of cas: 27469-61-0.

Direct inhibition of GPX4 requires covalent modification of the active-site selenocysteine. While phenotypic screening has revealed that activated alkyl chlorides and masked nitrile-oxides can inhibit GPX4 covalently, a systematic assessment of potential electrophilic warheads with the capacity to inhibit cellular GPX4 has been lacking. Here we survey more than 25 electrophilic warheads across several distinct GPX4-targeting scaffolds. Surprisingly, we find that electrophiles with attenuated reactivity compared to chloroacetamides are unable to target GPX4. The highly reactive propiolamide warheads we uncover in this study highlight the potential need for masking strategies similar to those we have described for nitrile-oxide-based GPX4 inhibitors. Finally, our observations that there are spatial requirements between warhead and scaffold for achieving optimal GPX4 targeting and that certain low-mol.-weight analogs inhibit GPX4 with selectivity suggest that rational design of GPX4 inhibitors may be a productive approach. The generation of ligand-bound crystal structures to facilitate such studies should therefore be prioritized by the field.

Here is just a brief introduction to this compound(27469-61-0)SDS of cas: 27469-61-0, more information about the compound(1-(Bis(4-chlorophenyl)methyl)piperazine) is in the article, you can click the link below.

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov’t, ACS Chemical Neuroscience called Evaluation of NHS Carbamates as a Potent and Selective Class of Endocannabinoid Hydrolase Inhibitors, Author is Niphakis, Micah J.; Cognetta, Armand B.; Chang, Jae Won; Buczynski, Matthew W.; Parsons, Loren H.; Byrne, Frederika; Burston, James J.; Chapman, Victoria; Cravatt, Benjamin F., which mentions a compound: 27469-61-0, SMILESS is ClC1=CC=C(C=C1)C(N2CCNCC2)C3=CC=C(Cl)C=C3, Molecular C17H18Cl2N2, Formula: C17H18Cl2N2.

Monoacylglycerol lipase (MAGL) is a principal metabolic enzyme responsible for hydrolyzing the endogenous cannabinoid (endocannabinoid) 2-arachidonoylglycerol (2-AG). Selective inhibitors of MAGL offer valuable probes to further understand the enzyme’s function in biol. systems and may lead to drugs for treating a variety of diseases, including psychiatric disorders, neuroinflammation, and pain. N-Hydroxysuccinimidyl (NHS) carbamates have recently been identified as a promising class of serine hydrolase inhibitors that shows minimal cross-reactivity with other proteins in the proteome. Here, the authors explore NHS carbamates more broadly and demonstrate their potential as inhibitors of endocannabinoid hydrolases and addnl. enzymes from the serine hydrolase class. The authors extensively characterize an NHS carbamate MJN110 as a potent, selective, and in-vivo-active MAGL inhibitor. Finally, the authors demonstrate that MJN110 alleviates mech. allodynia in a rat model of diabetic neuropathy, marking NHS carbamates as a promising class of MAGL inhibitors.

Compound(27469-61-0)Formula: C17H18Cl2N2 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(1-(Bis(4-chlorophenyl)methyl)piperazine), if you are interested, you can check out my other related articles.

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis and hypocholesterolemic activity of some N-diphenylmethylpiperazine derivatives, published in 1991-09-30, which mentions a compound: 27469-61-0, mainly applied to diphenylmethylpiperazine preparation hypocholesterolemic; piperazine diphenylmethyl preparation hypocholesterolemic, Name: 1-(Bis(4-chlorophenyl)methyl)piperazine.

The synthesis and preliminary assays as hypocholesterolemic agents of five N-phenylmethylpiperazines I [ R = PhCC, 2-(2-thienyl)ethynyl, 2-(2-thienylvinyl); R1 = H, Cl] are described. Thus, 2-thienylacetylene was treated with 1-benphydrylpiperazine and HCHO to give 91% I (R = PhCC, R1 = Cl). The evaluations were carried out in hypercholesterolemic mice and two of these compounds were more effective than bezafibrate in the test employed. The di-p-chloro substituted compounds showed higher activity than their corresponding dechlorinated analogs.

Compound(27469-61-0)Name: 1-(Bis(4-chlorophenyl)methyl)piperazine received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(1-(Bis(4-chlorophenyl)methyl)piperazine), if you are interested, you can check out my other related articles.

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

COA of Formula: C17H18Cl2N2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1-(Bis(4-chlorophenyl)methyl)piperazine, is researched, Molecular C17H18Cl2N2, CAS is 27469-61-0, about Validation of Model of Cytochrome P450 2D6: An in Silico Tool for Predicting Metabolism and Inhibition. Author is Kemp, Carol A.; Flanagan, Jack U.; van Eldik, Annamaria J.; Marechal, Jean-Didier; Wolf, C. Roland; Roberts, Gordon C. K.; Paine, Mark J. I.; Sutcliffe, Michael J..

There has been much interest in the development of a predictive model of cytochrome P 450 2D6 particularly because this enzyme is involved in the oxidation of at least 50 drugs. Previously we have described the combined use of homol. modeling and mol. docking to correctly position a range of substrates in the CYP2D6 active site with the known sites of metabolism above the heme. Here, our approach identifies correctly the site of metabolism of the atypical (no basic nitrogen) cytochrome P 450 2D6 substrate, spirosulfonamide. The same method is used to screen a small compound database for cytochrome P 450 2D6 inhibition. A database containing 33 compounds from the National Cancer Institute database was docked into our cytochrome P 450 2D6 homol. model using the program GOLDv2.0. Exptl. IC50 values for the 33 compounds were determined; comparison with the corresponding docked scores revealed a correlation with a regression coefficient of r2 = 0.61 (q2 = 0.59). The method was able to discriminate between tight and weak binding compounds and correctly identified several novel inhibitors. The results therefore suggest that our approach, which combines homol. modeling with mol. docking, has produced a useful predictive in silico tool for cytochrome P 450 2D6 inhibition, which is best used as one filter in a multifilter database screen.

Compound(27469-61-0)COA of Formula: C17H18Cl2N2 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(1-(Bis(4-chlorophenyl)methyl)piperazine), if you are interested, you can check out my other related articles.

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Recommanded Product: 27469-61-0. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 1-(Bis(4-chlorophenyl)methyl)piperazine, is researched, Molecular C17H18Cl2N2, CAS is 27469-61-0, about Development of small-molecule probes that selectively kill cells induced to express mutant RAS.

Synthetic lethal screening is a chem. biol. approach to identify small mols. that selectively kill oncogene-expressing cell lines with the goal of identifying pathways that provide specific targets against cancer cells. We performed a high-throughput screen of 303,282 compounds from the National Institutes of Health-Mol. Libraries Small Mol. Repository (NIH-MLSMR) against immortalized BJ fibroblasts expressing HRASG12V followed by a counterscreen of lethal compounds in a series of isogenic cells lacking the HRASG12V oncogene. This effort led to the identification of two novel mol. probes (PubChem CID 3689413, ML162 and CID 49766530, ML210) with nanomolar potencies and 4-23-fold selectivities, which can potentially be used for identifying oncogene-specific pathways and targets in cancer cells.

Compound(27469-61-0)Recommanded Product: 27469-61-0 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(1-(Bis(4-chlorophenyl)methyl)piperazine), if you are interested, you can check out my other related articles.

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-(Bis(4-chlorophenyl)methyl)piperazine( cas:27469-61-0 ) is researched.Computed Properties of C17H18Cl2N2.Shivaprakash, S.; Kiran, K. R.; Diwakar, Latha; Reddy, G. Chandrasekara published the article 《Synthesis and in-vitro study of novel (Z)-1-benzhydryl-4-cinnamylpiperazine derivatives as potential anticancer agents》 about this compound( cas:27469-61-0 ) in International Journal of Pharmacy and Pharmaceutical Sciences. Keywords: piperazine cinnamyl benzhydryl preparation human anticancer; acetaldehyde piperazinyl benzhydryl preparation diastereoselective Wittig benzyltriphenyl phosphonium. Let’s learn more about this compound (cas:27469-61-0).

A series of novel (Z)-1-benzhydryl-4-cinnamylpiperazines I [R1 = R2 = Ph, 4-ClC6H4, 4-MeC6H4, 4-FC6H4; R1 = Ph, R2 = 4-ClC6H4, 4-BrC6H4; R3 = Ph, 4-MeOC6H4, 3,5-(MeO)2C6H3, piperonyl, etc.] was synthesized in six steps starting from the corresponding benzophenones R1COR2. The final step was Wittig condensation of the appropriate benzyltriphenylphosphonium halides R3CH2P+Ph3 X- (X = Cl, Br) with 1-benzhydryl-4-(formylmethyl)piperazines, which afforded pure (Z)-1-benzhydryl-4-cinnamylpiperazines I. The anticancer potential (MTT assay) of the synthesized compounds was tested against human cervical cancer (HeLa) and murine microglial (BV-2) cell lines. The compound I (R1 = R2 = 4-FC6H4; R3 = Ph) (cis-flunarizine) exhibited exceptionally superior activity against both HeLa and BV-2 cell lines with IC50 value of 13.23±3.51 μM and 23.1±4.12 μM, resp. Hence, this compound may be considered as a potential lead mol. for further development.

Compound(27469-61-0)Computed Properties of C17H18Cl2N2 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(1-(Bis(4-chlorophenyl)methyl)piperazine), if you are interested, you can check out my other related articles.

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

SDS of cas: 27469-61-0. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1-(Bis(4-chlorophenyl)methyl)piperazine, is researched, Molecular C17H18Cl2N2, CAS is 27469-61-0, about Acrylamide derivatives as antiallergic agents. 2. Synthesis and structure activity relationships of N-[4-[4-(diphenylmethyl)-1-piperazinyl]butyl]-3-(3-pyridyl)acrylamides. Author is Nishikawa, Yoshinori; Shindo, Tokuhiko; Ishii, Katsumi; Nakamura, Hideo; Kon, Tatsuya; Uno, Hitoshi.

A new series of 3-(3-pyridyl)acrylamides, e.g., I (R = H, R1 = 4-F, 4-Cl, 4-OMe, 3-Me, 4-Me, R2 = H, 4-Cl, 4-Me; R = 2-Cl, 2-NHMe, 2-Me, 5-F, 5-Cl, 5-Br, 5-OMe, 5-OH, 6-Cl, 6-OMe, 6-Me, 6-Bu, R1 = R2 = H), and 5-(3-pyridyl)-2,4-pentadienamides, e.g., II (R = H, Me, n = 3,4) were prepared and evaluated for antiallergic activity. Several of these compounds exhibited more potent inhibitory activities than the parent compound I (R = R1 = R2 = H) against the rat passive cutaneous anaphylaxis (PCA) reaction and the enzyme 5-lipoxygenase. Particularly, I (R = 6-Me, R1 = R2 = H) (III) showed an ED50 value of 3.3 mg/kg po in the rat PCA test, which was one-fifth of ketotifen and oxatomide. As compared with ketotifen and oxatomide, III showed a better balance of antiallergic properties due to inhibition of chem. mediator release, inhibition of 5-lipoxygenase, and antagonism of histamine.

From this literature《Acrylamide derivatives as antiallergic agents. 2. Synthesis and structure activity relationships of N-[4-[4-(diphenylmethyl)-1-piperazinyl]butyl]-3-(3-pyridyl)acrylamides》,we know some information about this compound(27469-61-0)SDS of cas: 27469-61-0, but this is not all information, there are many literatures related to this compound(27469-61-0).

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Jones, C. David; Winter, Mark A.; Hirsch, Kenneth S.; Stamm, Nancy; Taylor, Harold M.; Holden, Howard E.; Davenport, James D.; Krumkalns, Eriks V.; Suhr, Robert G. researched the compound: 1-(Bis(4-chlorophenyl)methyl)piperazine( cas:27469-61-0 ).Related Products of 27469-61-0.They published the article 《Estrogen synthetase inhibitors. 2. Comparison of the in vitro aromatase inhibitory activity for a variety of nitrogen heterocycles substituted with diarylmethane or diarylmethanol groups》 about this compound( cas:27469-61-0 ) in Journal of Medicinal Chemistry. Keywords: heterocycle nitrogen diphenylmethyl preparation aromatase inhibition; imidazole diphenylmethyl preparation aromatase inhibitor; pyridine diphenylmethyl preparation aromatase inhibitor. We’ll tell you more about this compound (cas:27469-61-0).

The preparation and in vitro aromatase-inhibitory activity of a wide variety of heterocyclic diphenylmethane derivatives, e.g., (p-ClC4H4)2CRR1 (R = imidazolyl, pyridyl, pyrimidyl, etc.; R1 = H, HO, 1-imidazolyl), are described. Thus (p-ClC4H4)2CHCl was treated with imidazole in DMF containing NaH to give 1-[bis(p-chlorophenyl)methyl]imidazole. The choice of the 2 diaryl-bearing moieties as a vehicle for evaluating the heterocycles was made by comparing a series of imidazole- and pyridine-derived compounds with similar pyrimidine compounds reported previously. A structural model for the most active compounds is also presented. The activity of a related series of compounds containing 2 heterocyclic moieties was consistent with the model. Many of the compounds evaluated, including representatives of the pyridine, imidazole, pyrimidine, pyrazole, triazole, thiazole, and isothiazole classes, exhibit EC50 potencies for aromatase inhibition at low nanomolar levels. These compounds are at least as potent as other nonsteroidal aromatase inhibitors reported previously.

From this literature《Estrogen synthetase inhibitors. 2. Comparison of the in vitro aromatase inhibitory activity for a variety of nitrogen heterocycles substituted with diarylmethane or diarylmethanol groups》,we know some information about this compound(27469-61-0)Related Products of 27469-61-0, but this is not all information, there are many literatures related to this compound(27469-61-0).

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics