Category: 41340-25-4

Economically feasible strategy for confirmation of pharmaceuticals in hospital effluent using screening analysis was written by Cardoso, Renata M.;Dallegrave, Alexsandro;Becker, Raquel W.;Araujo, Debora S.;Sirtori, Carla. And the article was included in Analytical Methods in 2020.Formula: C17H21NO3 This article mentions the following:

The contamination of aquatic systems by pharmaceuticals has received considerable attention in recent decades, because these substances are increasingly detected in the environment. This is due to the abundant use of pharmaceuticals by the population and, consequently, their constant introduction into aquatic systems through domestic, industrial, and hospital wastewaters. Hospital effluents have highly complex compositions and present potential toxicity towards the environment. In this work, a screening methodol. was developed to evaluate the occurrence of pharmaceutical products in hospital wastewater, using a viable, easy, and economical strategy employing com. pharmaceutical compounds for screening anal. Six samplings of hospital wastewater were carried out monthly (from winter until summer). The samples were filtered and pre-concentrated/extracted using solid phase extraction (SPE). The pharmaceuticals screening procedure required the construction of two databases, one for each ionization mode (pos. and neg.), which contained information that allowed the identification of the presence of these pharmaceuticals in the studied samples. Com. pharmaceutical compounds were used as anal. standards Based on this strategy and, using liquid chromatog. coupled to high resolution mass spectrometry, it was possible to screen 110 pharmaceuticals and, from these, to confirm the presence of 38 pharmaceuticals in analyzed samples. These results indicate the analytes that should be taken into account in the further development of quant. methods for pharmaceutical anal. In the experiment, the researchers used many compounds, for example, 2-(1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid (cas: 41340-25-4Formula: C17H21NO3).

2-(1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid (cas: 41340-25-4) belongs to tetrahydropyran derivatives. Dihydropyrans and tetrahydropyrans are examples of cyclic ethers widespread in nature. 2-(Arylmethylene)cyclopropylcarbinols could be converted to the corresponding tetrahydropyrans stereoselectively in the presence of Brønsted acids under mild conditions. A plausible Prins-type reaction mechanism has been proposed.Formula: C17H21NO3

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Machine Learning for Discovery of GSK3β Inhibitors was written by Vignaux, Patricia A.;Minerali, Eni;Foil, Daniel H.;Puhl, Ana C.;Ekins, Sean. And the article was included in ACS Omega in 2020.SDS of cas: 41340-25-4 This article mentions the following:

Alzheimer’s disease (AD) is the most common cause of dementia, affecting approx. 35 million people worldwide. The current treatment options for people with AD consist of drugs designed to slow the rate of decline in memory and cognition, but these treatments are not curative, and patients eventually suffer complete cognitive injury. With the substantial amounts of published data on targets for this disease, we proposed that machine learning software could be used to find novel small-mol. treatments that can supplement the AD drugs currently on the market. In order to do this, we used publicly available data in ChEMBL to build and validate Bayesian machine learning models for AD target proteins. The first AD target that we have addressed with this method is the serine-threonine kinase glycogen synthase kinase 3 beta (GSK3β), which is a proline-directed serine-threonine kinase that phosphorylates the microtubule-stabilizing protein tau. This phosphorylation prompts tau to dissociate from the microtubule and form insoluble oligomers called paired helical filaments, which are one of the components of the neurofibrillary tangles found in AD brains. Using our Bayesian machine learning model for GSK3β consisting of 2368 mols., this model produced a five-fold cross validation ROC of 0.905. This model was also used for virtual screening of large libraries of FDA-approved drugs and clin. candidates. Subsequent testing of selected compounds revealed a selective small-mol. inhibitor, ruboxistaurin(I), with activity against GSK3β (avg IC₅₀ = 97.3 nM) and GSK3α (IC₅₀ = 695.9 nM). Several other structurally diverse inhibitors were also identified. We are now applying this machine learning approach to addnl. AD targets to identify approved drugs or clin. trial candidates that can be repurposed as AD therapeutics. This represents a viable approach to accelerate drug discovery and do so at a fraction of the cost of traditional high throughput screening. In the experiment, the researchers used many compounds, for example, 2-(1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid (cas: 41340-25-4SDS of cas: 41340-25-4).

2-(1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid (cas: 41340-25-4) belongs to tetrahydropyran derivatives. Numerous natural products have tetrahydropyran skeleton as the building block for designing new natural products and their derivatives e.g. aplysiatoxins, avermectins, oscillatoxins, talaromycins, latrunculins and acutiphycins. There is large number of marine macrolide natural products that contain tetrahydropyran and tetrahydrofuran ring together. For instance, goniodomin A (actin targeting polyether), prorocentrolide (toxin halistatins), and percentotoxineSDS of cas: 41340-25-4

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Liquid chromatographic methods for separation, determination, and bioassay of enantiomers of etodolac: A review was written by Singh, Manisha;Sethi, Sonika;Bhushan, Ravi. And the article was included in Journal of Separation Science in 2020.Quality Control of 2-(1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid This article mentions the following:

The control of enantiomeric purity and determination of individual enantiomeric drug mols. remains the subject of importance for clin., anal., and regulatory purposes and to facilitate an accurate evaluation of the risks posed by them to human health. A large number of pharmaceuticals are marketed and administered as racemates. Etodolac is among such nonsteroidal anti-inflammatory drugs. Overall literature reports on its enantioseparation are scanty. Liquid chromatog. (LC) methods of enantioseparation of (±)-etodolac, including certain unconventional ones, are well covered and discussed in this paper. Methods of direct approach without using chiral columns or chiral thin-layer chromatog. plate and of indirect approach using certain chiral derivatizing agents such as (S)-naproxen and (S)-levofloxacin are described. Most interesting aspects include establishment of structure and mol. asymmetry of chem. different types of diastereomeric derivatives using liquid chromatog. with mass spectrometry (LC-MS), ¹H NMR spectroscopy and by drawing conformations in three dimensional views by using certain software. The methods provide chirality recognition even in the absence of pure enantiomers. Besides, recovery of pure enantiomers by detagging or via solubility difference of chiral inducing reagent and the analyte, without racemization at any stage, has been achieved. The limits of detection and quantification are much lower than the industry benchmarks. In the experiment, the researchers used many compounds, for example, 2-(1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid (cas: 41340-25-4Quality Control of 2-(1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid).

2-(1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid (cas: 41340-25-4) belongs to tetrahydropyran derivatives. Dihydropyrans and tetrahydropyrans are examples of cyclic ethers widespread in nature. The reaction of tertiary 1,4- and 1,5-diols with cerium ammonium nitrate at room temperature gives tetrahydrofuran and tetrahydropyran derivatives in high yield and stereoselectivity. Various fragrant compounds have been synthesized using this method.Quality Control of 2-(1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

New Matrix Compounds for the Detection of Carboxyl-Containing Nonsteroidal Anti-Inflammatory Drugs by MALDI Mass Spectrometry was written by Khrushcheva, M. L.;Krivosheina, M. S.;Matveeva, M. D.;Zhilyaev, D. I.;Borisov, R. S.. And the article was included in Russian Journal of Applied Chemistry in 2020.Related Products of 41340-25-4 This article mentions the following:

Abstract: The possibility of employing the method of mass spectrometry with matrix-assisted laser desorption/ionization (MALDI) for the rapid detection of carboxyl-containing nonsteroidal anti-inflammatory drugs has been studied. Comparison of the results obtained using the previously described and newly proposed as matrix compounds 4-(dimethylamino)benzaldehyde and N,N-dimethyl-p-phenylenediamine, showed that the latter provide the registration of mass spectra containing intense peaks of deprotonated mols. of all drugs used in the work. Comparison of the time required for their detection by various mass spectrometric methods has shown that MALDI mass spectrometry provides the highest performance in streaming anal. In the experiment, the researchers used many compounds, for example, 2-(1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid (cas: 41340-25-4Related Products of 41340-25-4).

2-(1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid (cas: 41340-25-4) belongs to tetrahydropyran derivatives. Tetrahydropyrans are also used as important solvents, as chemical intermediate and as monomer for ring-opening polymerization. The reaction of tertiary 1,4- and 1,5-diols with cerium ammonium nitrate at room temperature gives tetrahydrofuran and tetrahydropyran derivatives in high yield and stereoselectivity. Various fragrant compounds have been synthesized using this method.Related Products of 41340-25-4

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Etodolac nanosuspension based gel for enhanced dermal delivery: in vitro and in vivo evaluation was written by Karakucuk, Alptug;Tort, Serdar;Han, Sevtap;Oktay, Ayse Nur;Celebi, Nevin. And the article was included in Journal of Microencapsulation in 2021.Safety of 2-(1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid This article mentions the following:

The objective of this study was to develop dermal nanosuspension (NS) based gel formulation of etodolac (ETD). Etodolac nanosuspension (ETD-NS) was prepared by wet milling method and dispersed in hydroxypropyl methylcellulose (NS-HPMC) or hydroxyethyl cellulose (NS-HEC) gels. Rheol. and mech. properties were investigated. In vitro and ex vivo permeability studies were performed. Topical anti-inflammatory and analgesic activity were evaluated in regard to carrageenan-induced inflammatory paw edema and radiant heat tail-flick method, resp. The ETD-NS with approx. 190 nm particle size (PS), 0.16 polydispersity index (PDI), and -15 mV zeta potential (ZP) values were obtained. The work of bioadhesion values of NS-HEC and NS-HPMC gels were 0.229 mJ/cm² for both gels. Dermal permeation of ETD from NS-HEC gel (7.18%) was found significantly higher than the NS-HPMC gel (4.56%). Enhanced anti-inflammatory and analgesic activity of NS-HEC gels were observed in comparison with micronised ETD. ETD-NS based gel formulation is promising for topical delivery of ETD. In the experiment, the researchers used many compounds, for example, 2-(1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid (cas: 41340-25-4Safety of 2-(1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid).

2-(1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid (cas: 41340-25-4) belongs to tetrahydropyran derivatives. Dihydropyrans and tetrahydropyrans are examples of cyclic ethers widespread in nature. The reaction of tertiary 1,4- and 1,5-diols with cerium ammonium nitrate at room temperature gives tetrahydrofuran and tetrahydropyran derivatives in high yield and stereoselectivity. Various fragrant compounds have been synthesized using this method.Safety of 2-(1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Early exposure of pregnant women to non-steroidal anti-inflammatory drugs delivered outside hospitals and preterm birth risk: nationwide cohort study was written by Quantin, C.;Yamdjieu Ngadeu, C.;Cottenet, J.;Escolano, S.;Bechraoui-Quantin, S.;Rozenberg, P.;Tubert-Bitter, P.;Gouyon, J-B.. And the article was included in BJOG in 2021.Related Products of 41340-25-4 This article mentions the following:

To assess the risk of preterm birth associated with nonsteroidal anti-inflammatory drugs (NSAIDs), focusing on early exposure in the period from conception to 22 wk of gestation (WG). National population-based retrospective cohort study. The French National Health Insurance Database that includes hospital discharge data and health claims data. Singleton pregnancies (2012-2014) with a live birth occurring after 22WG from women between 15 and 45 years old and insured the year before the first day of gestation and during pregnancy were included. We excluded pregnancies for which anti-inflammatory medications were dispensed after 22WG. The association between exposure and risk of preterm birth was evaluated with GEE models, adjusting on a large number of covariables, socio-demog. variables, maternal comorbidities, prescription drugs and pregnancy complications. Main outcome measures : Prematurity, defined as a birth that occurred before 37WG. Among our 1 598 330 singleton pregnancies, early exposure to non-selective NSAIDs was associated with a significantly increased risk of preterm birth, regardless of the severity of prematurity: adjusted odds ratio (aOR) = 1.76 (95CI 1.54-2.00) for extreme prematurity (95CI 22-27WG), 1.28 (95CI 1.17-1.40) for moderate prematurity (28-31WG) and 1.08 (95CI 1.05-1.11) for late prematurity (32-36WG), with non-overlapping confidence intervals. We identified five NSAIDs for which the risk of premature birth was significantly increased: ketoprofen, flurbiprofen, nabumetone, etodolac and indomethacin: for the latter, aOR = 1.92 (95CI 1.37-2.70) with aOR = 9.33 (95CI 3.75-23.22) for extreme prematurity. Overall, non-selective NSAID use (delivered outside hospitals) during the first 22WG was found to be associated with an increased risk of prematurity. However, the association differs among NSAIDs. French study for which early exposure to non-selective NSAIDs was associated with increased risk of prematurity. In the experiment, the researchers used many compounds, for example, 2-(1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid (cas: 41340-25-4Related Products of 41340-25-4).

2-(1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid (cas: 41340-25-4) belongs to tetrahydropyran derivatives. Numerous natural products have tetrahydropyran skeleton as the building block for designing new natural products and their derivatives e.g. aplysiatoxins, avermectins, oscillatoxins, talaromycins, latrunculins and acutiphycins. The Prins reaction of homoallylic alcohols with aldehydes afforded an alternative method for the preparation of tetrahydropyrans.Related Products of 41340-25-4

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics