With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4677-18-3,2-(Tetrahydro-2H-pyran-4-yl)ethanol,as a common compound, the synthetic route is as follows.
Mesyl chloride (2.9 g, 25.3 mmol) was added dropwise to a solution of 2- (tetrahydro-2H-pyran-4-yl)ethan-1-ol (2.9 g, 22.3 mmol) in dichloromethane (20 ml) and triethylamine (2.76 g, 27.3 mmol) at 0 C.Then reaction mixture was stirred at rt for 4 h. A saturated solution of sodium bicarbonate (10 ml) was added to the reaction mixture and the product was extracted with dichloromethane (3×20 ml). The combined organic layer was dried over anhydrous sodium sulphate and concentrated under reduced pressure to afford the title compound which was caffied forward to the next step without further purification.
The synthetic route of 4677-18-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; EPIZYME, INC.; CHESWORTH, Richard; MITCHELL, Lorna, Helen; CAMPBELL, John, Emmerson; REITER, Lawrence, Alan; SWINGER, Kerren, Kalai; (387 pag.)WO2016/44626; (2016); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics