Category: 50501-07-0

COA of Formula: C11H13NO2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Ethyl indoline-2-carboxylate, is researched, Molecular C11H13NO2, CAS is 50501-07-0, about Stereochemically Rich Polycyclic Amines from the Kinetic Resolution of Indolines through Intramolecular Povarov Reactions. Author is Min, Chang; Seidel, Daniel.

Under control of a chiral Bronsted acid catalyst, racemic indolines I (R1 = H, 4-Me, 5-Br, 5-F, 5-MeO; R2 = Me, EtO2C, Ph, 4-MeOC6H4, etc.) underwent intramol. Povarov reactions with achiral aromatic aldehydes II (R3 = Ph, 3-ClC6H4, 4-MeC6H4, 1-naphthyl, etc.; R4 = H, 5-Br, 3-MeO, etc.) bearing a pendent dienophile. One enantiomer of the indoline reacted preferentially, resulting in the highly enantio- and diastereoselective formation of polycyclic heterocycles III with four stereogenic centers. This kinetic resolution approach exploits the differential formation/reactivity of diastereomeric ion pairs.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Ethyl indoline-2-carboxylate( cas:50501-07-0 ) is researched.Recommanded Product: 50501-07-0.Sahoo, Manoj K.; Balaraman, Ekambaram published the article 《Room temperature catalytic dehydrogenation of cyclic amines with the liberation of H2 using water as a solvent》 about this compound( cas:50501-07-0 ) in Green Chemistry. Keywords: quinoline preparation; tertahydroquinoline dehydrogenation ruthenium catalyst cobalt visible light; indoline preparation; dihydroindole dehydrogenation ruthenium catalyst cobalt visible light; quinoxaline preparation; tetrahydroquinoxaline dehydrogenation ruthenium catalyst cobalt visible light. Let’s learn more about this compound (cas:50501-07-0).

Catalytic dehydrogenation of cyclic amines, in particular partially saturated N-heterocycles to N-heterocyclic arenes, quinolines, indolines and quinoxalines with the removal of mol. hydrogen as the sole byproduct in water was reported. This dehydrogenation reaction proceeded smoothly under very mild and benign conditions and operates at room temperature This distinctive reactivity was achieved under dual catalytic conditions by merging the visible-light active [Ru(bpy)3]2+ as the photoredox catalyst and a newly synthesized cobalt complex as the proton-reduction catalyst. A detailed mechanistic study (control experiments, electrochem. studies, UV-visible experiments) was presented for the present dual catalysis.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, ChemCatChem called A Reusable Cobalt Catalyst for Reversible Acceptorless Dehydrogenation and Hydrogenation of N-Heterocycles, Author is Jaiswal, Garima; Subaramanian, Murugan; Sahoo, Manoj K.; Balaraman, Ekambaram, which mentions a compound: 50501-07-0, SMILESS is O=C(C1NC2=C(C=CC=C2)C1)OCC, Molecular C11H13NO2, Quality Control of Ethyl indoline-2-carboxylate.

A highly efficient reusable cobalt-based heterogeneous catalyst for reversible dehydrogenation and hydrogenation of N-heterocycles was repoted. Both the acceptorless dehydrogenation (ADH) and the hydrogenation processes operated under mild and benign conditions.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Journal of Medicinal Chemistry called α2-Adrenergic agonists/antagonists: the synthesis and structure-activity relationships of a series of indolin-2-yl and tetrahydroquinolin-2-yl imidazolines, Author is Hlasta, Dennis J.; Luttinger, Daniel; Perrone, Mark H.; Silbernagel, Marla J.; Ward, Susan J.; Haubrich, Dean R., which mentions a compound: 50501-07-0, SMILESS is O=C(C1NC2=C(C=CC=C2)C1)OCC, Molecular C11H13NO2, Related Products of 50501-07-0.

The synthesis and α2-adrenergic activity of a series of indolin-2-yl- and tetrahydroquinolin-2-ylimidazolines, e.g. I (R = Me, Et, allyl, Ph, CH2Ph, etc.; R1 = 5-F, 5-Cl, etc.) and II (R = H, Me) are described. The indolin-2-ylimidazoline I (R = Me, R1 = H) has potent α2-adrenergic agonist and antagonist activity. The modification of the substituents on the indoline ring of I led to the separation of these activities. Substitution on the aromatic ring of I with halogen or increasing the size of the N-alkyl substituent of I gave α2-adrenergic antagonists without agonist activity. The N-allylindoline I (R = allyl, R1 = H) is more potent than idazoxan in vitro and is equipotent in vivo, but is less receptor-selective (α2 vs. α1) than idazoxan. cis-1,3-Dimethylindolin-2-ylimidazoline is an α2-adrenergic agonist equal in potency to clonidine in vitro, whereas trans-1,3-dimethylindolin-2-ylimidazoline is a moderately potent α2-adrenergic antagonist.

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Product Details of 50501-07-0. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Ethyl indoline-2-carboxylate, is researched, Molecular C11H13NO2, CAS is 50501-07-0, about Purification, identification and characterization of an esterase with high enantioselectivity to (S)-ethyl indoline-2-carboxylate. Author is Zhang, Yin-Jun; Chen, Chang-Sheng; Liu, Hao-Tian; Chen, Jia-Lin; Xia, Ying; Wu, Shi-Jin.

Objective: To purify an esterase which can selectively hydrolyze (R,S)-Et indoline-2-carboxylate to produce (S)-indoline-2-carboxylic acid and characterize its enzymic properties. Results: An intracellular esterase from Bacillus aryabhattai B8W22 was isolated and the purified protein was identified as a carboxylesterase by MALDI-TOF mass spectrometry. The enzyme (named BaCE) was 59.03-fold purification determined to be of approx. 35 kDa. Its specific activity was 0.574 U/mL with 20% yield. The enzyme showed maximum activity at pH 8.5 and 30°C and was stable at 20-30°C using pNPB as the substrate. The esterase demonstrated high enantioselectivity toward (S)-Et indoline-2-carboxylate with 96.55% e.e.p at 44.39% conversion, corresponding to an E value of 133.45. Conclusions: In this study, a new esterase BaCE with an apparent mol. mass of 35 kDa was purified to homogeneity for the first time. The esterase from Bacillus aryabhattai B8W22 was isolated with a purification more than 59-fold and a yield of 20% by anion exchange chromatog. and hydrophobic interaction chromatog. And its biochem. characterization were described in detail with pNPB as substrate. It displayed high enantioselectivity toward (S)-Et indoline-2-carboxylate. We next plan to highly express esterase BaCE in Escherichia coli, and apply it to industrial production of (S)-indoline-2-carboxylic acid.

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Sahoo, Manoj K.; Jaiswal, Garima; Rana, Jagannath; Balaraman, Ekambaram published an article about the compound: Ethyl indoline-2-carboxylate( cas:50501-07-0,SMILESS:O=C(C1NC2=C(C=CC=C2)C1)OCC ).Category: tetrahydropyran. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:50501-07-0) through the article.

For the first time the catalytic oxidative dehydrogenation of N-heterocycles by a visible-light organo-photoredox catalyst with low catalyst loading (0.1-1 mol %) was reported. The reaction proceeded efficiently under base- and additive-free conditions with ambient air at room temperature The utility of this benign approach was demonstrated by the synthesis of various pharmaceutically relevant N-heteroarenes such as quinolines, quinoxalines, quinazolines, acridines and indoles.

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Srinath, S.; Abinaya, R.; Prasanth, Arun; Mariappan, M.; Sridhar, R.; Baskar, B. published an article about the compound: Ethyl indoline-2-carboxylate( cas:50501-07-0,SMILESS:O=C(C1NC2=C(C=CC=C2)C1)OCC ).Recommanded Product: Ethyl indoline-2-carboxylate. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:50501-07-0) through the article.

A simple and efficient method for the oxidative dehydrogenation (ODH) of partially saturated N-heterocycles (indolines, tetrahydro-β-carbolines and tetrahydro(iso)quinolines) e.g., I is described using a reusable, homogeneous cobalt-phthalocyanine photoredox catalyst II (R = SO3Na; M = Co) in a biphasic medium. A biphasic system offers an advantage of easy separation of the product and an efficient reusability of the homogeneous photoredox catalyst. Also, the current system significantly helps to overcome the solubility issue of the substrate and catalyst at room temperature Its potential applications to organic transformations are demonstrated by the synthesis of various biol. active N-heterocycles (indoles, β-carbolines, (iso)quinolines) e.g., III and natural products such as eudistomin U, norharmane, and harmane and precursors to perlolyrine and flazin. Without isolation and purification, the catalyst solution can be reused up to 5 times with almost comparable reactivity. Furthermore, the efficiency of the reaction was demonstrated on a gram scale. To the best of our knowledge, this is the first report on ODH reactions using a non noble, reusable and homogeneous cobalt photoredox catalyst under environmentally friendly conditions.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Journal of Medicinal Chemistry called (Mercaptopropanoyl)indoline-2-carboxylic acids and related compounds as potent angiotensin converting enzyme inhibitors and antihypertensive agents, Author is Kim, Dong H.; Guinosso, Charles J.; Buzby, George C. Jr.; Herbst, David R.; McCaully, Ronald J.; Wicks, Thomas C.; Wendt, Robert L., which mentions a compound: 50501-07-0, SMILESS is O=C(C1NC2=C(C=CC=C2)C1)OCC, Molecular C11H13NO2, HPLC of Formula: 50501-07-0.

Stereoisomers of 1-(3-mercapto-2-methyl-1-oxopropyl)indoline-2-carboxylic acid (I) and related compounds were synthesized and their ability to inhibit angiotensin converting enzyme (ACE) [9015-82-1] and to lower the systolic blood pressure of spontaneously hypertensive rats (SHR) examined All 4 possible stereoisomers of the precursor 1-[3-(benzoylthio)-2-methyl-1-oxopropyl]indoline-2-carboxylic acid were characterized with absolute stereochem. assignment. The removal of the benzoyl group of the precursor showed in vitro ACE inhibitory activity; the stereoisomer having the R,R configuration was essentially inactive. The mercaptan (S,S)-I was the most active ACE inhibitor, showing in vitro potency 3 times that of captopril. (S,S)-I exhibited oral antihypertensive activity 27 times that of captopril. The thio lactone obtained by cyclization of (S,S)-I as a potential prodrug was less potent than the parent compound in the ACE inhibitory and antihypertensive tests. Structure-activity relations are discussed.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called A Reusable Cobalt Catalyst for Reversible Acceptorless Dehydrogenation and Hydrogenation of N-Heterocycles, published in 2019, which mentions a compound: 50501-07-0, mainly applied to cobalt complex preparation surface structure; azaarene cobalt complex catalyst dehydrogenation; nitrogen heterocycle compound cobalt complex catalyst hydrogenation, Application In Synthesis of Ethyl indoline-2-carboxylate.

A highly efficient reusable cobalt-based heterogeneous catalyst for reversible dehydrogenation and hydrogenation of N-heterocycles was repoted. Both the acceptorless dehydrogenation (ADH) and the hydrogenation processes operated under mild and benign conditions.

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Safety of Ethyl indoline-2-carboxylate. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Ethyl indoline-2-carboxylate, is researched, Molecular C11H13NO2, CAS is 50501-07-0, about A biomass-derived N-doped porous carbon catalyst for the aerobic dehydrogenation of nitrogen heterocycles. Author is Liu, Jing-Jiang; Guo, Fu-Hu; Cui, Fu-Jun; Zhu, Ji-Hua; Liu, Xiao-Yu; Ullah, Arif; Wang, Xi-Cun; Quan, Zheng-Jun.

N-doped porous carbon (NC) was synthesized from sugar cane bagasse, which is a sustainable and widely available biomass waste. The preferred NC sample had a well-developed porous structure, a graphene-like surface morphol. and different N species. More importantly, the heterogeneous carbocatalyst exhibited superior catalytic performance in the aerobic dehydrogenation of various heterocyclic nitrogen compounds (49 examples, up to 96% yield), similar to that of C3N4 and GO. Characterization by TEM, BET and XPS accompanied by the EPR anal. revealed that the enhanced catalytic properties of NC came from its high activation ability for both O2 and heterocyclic nitrogen, attributed to the porous structure and pyridinic N (N-6) species, resp.

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