Category: 50501-07-0

Related Products of 50501-07-0. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Ethyl indoline-2-carboxylate, is researched, Molecular C11H13NO2, CAS is 50501-07-0, about Purification, identification and characterization of an esterase with high enantioselectivity to (S)-ethyl indoline-2-carboxylate.

Objective: To purify an esterase which can selectively hydrolyze (R,S)-Et indoline-2-carboxylate to produce (S)-indoline-2-carboxylic acid and characterize its enzymic properties. Results: An intracellular esterase from Bacillus aryabhattai B8W22 was isolated and the purified protein was identified as a carboxylesterase by MALDI-TOF mass spectrometry. The enzyme (named BaCE) was 59.03-fold purification determined to be of approx. 35 kDa. Its specific activity was 0.574 U/mL with 20% yield. The enzyme showed maximum activity at pH 8.5 and 30°C and was stable at 20-30°C using pNPB as the substrate. The esterase demonstrated high enantioselectivity toward (S)-Et indoline-2-carboxylate with 96.55% e.e.p at 44.39% conversion, corresponding to an E value of 133.45. Conclusions: In this study, a new esterase BaCE with an apparent mol. mass of 35 kDa was purified to homogeneity for the first time. The esterase from Bacillus aryabhattai B8W22 was isolated with a purification more than 59-fold and a yield of 20% by anion exchange chromatog. and hydrophobic interaction chromatog. And its biochem. characterization were described in detail with pNPB as substrate. It displayed high enantioselectivity toward (S)-Et indoline-2-carboxylate. We next plan to highly express esterase BaCE in Escherichia coli, and apply it to industrial production of (S)-indoline-2-carboxylic acid.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Collot, Valerie; Schmitt, Martine; Marwah, Padma; Bourguignon, Jean-Jacques researched the compound: Ethyl indoline-2-carboxylate( cas:50501-07-0 ).Related Products of 50501-07-0.They published the article 《Regiospecific functionalization of indole-2-carboxylates and diastereoselective preparation of the corresponding indolines》 about this compound( cas:50501-07-0 ) in Heterocycles. Keywords: diastereoselective preparation indoline; indolecarboxylate reaction. We’ll tell you more about this compound (cas:50501-07-0).

The N-acyl derivatives of 3-substituted indole-2-carboxylates prepared through several routes were submitted to catalytic hydrogenation affording either cis- or trans-indoline diastereomers after quant. C-2 epimerization.

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Name: Ethyl indoline-2-carboxylate. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Ethyl indoline-2-carboxylate, is researched, Molecular C11H13NO2, CAS is 50501-07-0, about Synthesis of Azoles Condensed with, or Linked to, Nitroxides. Author is Bognar, Balazs; Kalai, Tamas; Gulyas-Fekete, Gergely; Lazsanyi, Noemi; Hideg, Kalman.

Nitroxides connected to indoles, tetrazoles or 1,3,4-oxadiazoles were synthesized by conventional and microwave-assisted cyclization reactions. New approaches to pyrrole-, pyrazole-, and triazole-annulated nitroxides are described. The authors showed that a Diels-Alder reaction of a N-tert-butoxycarbonyl derivative of (4,4,6,6-tetramethyl-2,4,6,7-tetrahydro-5H-pyrrolo[3,4-c]pyridin-5-yl)oxidanyl gave polycyclic scaffolds condensed with a six-membered nitroxide. The synthesis of the target compounds was achieved using as starting materials 3-cyano-2,5-dihydro-2,2,5,5-tetramethyl-1H-pyrrol-1-yloxy radical, 4-cyano-3,6-dihydro-2,2,6,6-tetramethyl-1(2H)-pyridinyloxy radical, 4-cyano-2,2,6,6-tetramethyl-1-piperidinyloxy radical (TEMPO derivative), 3-formyl-2,5-dihydro-2,2,5,5-tetramethyl-1H-pyrrol-1-yloxy radical and similar nitroxide radical derivatives The title compounds thus formed included triazole-nitroxide radical derivatives, benzotriazole-nitroxide radical derivatives, pyrrole-nitroxide radical derivatives, indole-nitroxide radical derivatives and related substances.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Introduction of heterocycles at the 2-position of indoline as ester bioisosteres, published in 2004-02-20, which mentions a compound: 50501-07-0, mainly applied to indoline heterocyclic derivative preparation cyclization, Quality Control of Ethyl indoline-2-carboxylate.

Compounds were prepared with heterocyclic replacements for metabolically unstable esters of benzopyranyl indole-2-carboxylic esters, which showed good in vitro and in vivo cardioprotective efficacies possibly through the opening of mitochondrial ATP-sensitive potassium channel (KATP). Initially, indolin-2-yl-heterocycles were constructed using unprotected indoline-2-carboxylic acid, but the cyclization was proceeded with oxidation of the indoline ring to the indole, which did not react with benzopyranyl epoxide. An N-BOC group was introduced to deplete the electron d. of the indoline ring. Various indolin-2-yl-heterocycles, such as I and II, were prepared by the cyclization of the building blocks including carboxamide, β-hydroxy amide, hydrazide, nitrile starting from N-BOC-indoline-2-carboxylic acid.

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Bognar, Balazs; Kalai, Tamas; Gulyas-Fekete, Gergely; Lazsanyi, Noemi; Hideg, Kalman published an article about the compound: Ethyl indoline-2-carboxylate( cas:50501-07-0,SMILESS:O=C(C1NC2=C(C=CC=C2)C1)OCC ).Safety of Ethyl indoline-2-carboxylate. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:50501-07-0) through the article.

Nitroxides connected to indoles, tetrazoles or 1,3,4-oxadiazoles were synthesized by conventional and microwave-assisted cyclization reactions. New approaches to pyrrole-, pyrazole-, and triazole-annulated nitroxides are described. The authors showed that a Diels-Alder reaction of a N-tert-butoxycarbonyl derivative of (4,4,6,6-tetramethyl-2,4,6,7-tetrahydro-5H-pyrrolo[3,4-c]pyridin-5-yl)oxidanyl gave polycyclic scaffolds condensed with a six-membered nitroxide. The synthesis of the target compounds was achieved using as starting materials 3-cyano-2,5-dihydro-2,2,5,5-tetramethyl-1H-pyrrol-1-yloxy radical, 4-cyano-3,6-dihydro-2,2,6,6-tetramethyl-1(2H)-pyridinyloxy radical, 4-cyano-2,2,6,6-tetramethyl-1-piperidinyloxy radical (TEMPO derivative), 3-formyl-2,5-dihydro-2,2,5,5-tetramethyl-1H-pyrrol-1-yloxy radical and similar nitroxide radical derivatives The title compounds thus formed included triazole-nitroxide radical derivatives, benzotriazole-nitroxide radical derivatives, pyrrole-nitroxide radical derivatives, indole-nitroxide radical derivatives and related substances.

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Safety of Ethyl indoline-2-carboxylate. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Ethyl indoline-2-carboxylate, is researched, Molecular C11H13NO2, CAS is 50501-07-0, about Computational analysis of chiral recognition in Pirkle phases. Author is Lipkowitz, Kenny B.; Baker, Brian.

The relative retention orders and chromatog. separability factors for optical analytes on 2 com. available chiral stationary phases have been determined from statistical mol. modeling. The intermmol. potential-energy surfaces of the diastereomeric complexes formed between the chiral receptor and mirror image substrates are flat and reveal that both enantiomers tend to dock in the same general region around the receptor. How the receptor senses differences between mirror image analytes (enantiorecognition) is revealed with an algorithm that partitions the total binding energy into mol. fragments on the receptor. The fragments on the receptor most responsible for substrate binding are located and the fragments most responsible for enantioselection are discovered. The fragment bearing the stereogenic centers is generally not the most cognizant of differences between mirror image substrates, and the results are generally in agreement with previously proposed chiral recognition models.

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Yoshimura, Juji; Sugiyama, Yuichi; Nakamura, Hiroshi published the article 《Synthesis and substitution of 1,3,4,6-tetra-substituted-3,6-dihalo-2,5-piperazinediones》. Keywords: halopiperazinedione; piperazinedione dihalo; oxopiperazine dihalo.They researched the compound: Ethyl indoline-2-carboxylate( cas:50501-07-0 ).Quality Control of Ethyl indoline-2-carboxylate. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:50501-07-0) here.

Addition of Cl to 3,6-dimethylene- (I) and 3,6-dibenzylidene-1,4-dimethyl-2,5-piperazinediones gave isomers of the corresponding tetrachloride, e.g., II, and substitution of 1,3,4,6-tetramethyl-2,5-piperazinedione with Br also gave a tetrabromide III of the same type via successive elimination and addition reactions. Treatment of III with water and with methanolic NaOAc gave the corresponding 3,6-dihydroxy and dimethoxy derivatives, resp., while treatment with NaI, Na2S, NaSCN, or NaOSCMe gave only I and S in a good yield. Similar results were obtained in the case of octahydro-5H,10H-dipyrrolo[1,2-a:1′,2′-d]pyrazine-5,10-dione. However, bromination of 6,13-dioxo-6a,7,13a,14-tetrahydro-6H,13H-pyrazino[1,2-a:4,5-a’]diindole gave rise only to aromatization. Configurations of the isomers obtained and the reaction processes were discussed.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 50501-07-0, is researched, SMILESS is O=C(C1NC2=C(C=CC=C2)C1)OCC, Molecular C11H13NO2Journal, Synthetic Communications called Convenient synthesis of dioxopiperazines via aminolysis of α-(pyruvylamino) esters, Author is Marshall, J. A.; Schlaf, T. F.; Csernansky, J. G., the main research direction is pyrazinoindoledione thioacetyl; thioacetylpyrazinoindoledione; pyrrolopyrazinedione; indolecarboxylate cyclization methylamine; proline ester cyclization methylamine; dioxopiperazine.COA of Formula: C11H13NO2.

Dioxopiperazines I and II were prepared from indoline III by cyclizing with MeNH2 to give dioxopiperazine IV, which was dehydrated to methylene compound V. V added AcSH to give I and II. Analogous reactions starting with pyrrole VI gave dioxopiperazine VII.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Ethyl indoline-2-carboxylate(SMILESS: O=C(C1NC2=C(C=CC=C2)C1)OCC,cas:50501-07-0) is researched.COA of Formula: C11H13NO2. The article 《Synthesis and substitution of 1,3,4,6-tetra-substituted-3,6-dihalo-2,5-piperazinediones》 in relation to this compound, is published in Bulletin of the Chemical Society of Japan. Let’s take a look at the latest research on this compound (cas:50501-07-0).

Addition of Cl to 3,6-dimethylene- (I) and 3,6-dibenzylidene-1,4-dimethyl-2,5-piperazinediones gave isomers of the corresponding tetrachloride, e.g., II, and substitution of 1,3,4,6-tetramethyl-2,5-piperazinedione with Br also gave a tetrabromide III of the same type via successive elimination and addition reactions. Treatment of III with water and with methanolic NaOAc gave the corresponding 3,6-dihydroxy and dimethoxy derivatives, resp., while treatment with NaI, Na2S, NaSCN, or NaOSCMe gave only I and S in a good yield. Similar results were obtained in the case of octahydro-5H,10H-dipyrrolo[1,2-a:1′,2′-d]pyrazine-5,10-dione. However, bromination of 6,13-dioxo-6a,7,13a,14-tetrahydro-6H,13H-pyrazino[1,2-a:4,5-a’]diindole gave rise only to aromatization. Configurations of the isomers obtained and the reaction processes were discussed.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Liu, Jing-Jiang; Guo, Fu-Hu; Cui, Fu-Jun; Zhu, Ji-Hua; Liu, Xiao-Yu; Ullah, Arif; Wang, Xi-Cun; Quan, Zheng-Jun researched the compound: Ethyl indoline-2-carboxylate( cas:50501-07-0 ).Reference of Ethyl indoline-2-carboxylate.They published the article 《A biomass-derived N-doped porous carbon catalyst for the aerobic dehydrogenation of nitrogen heterocycles》 about this compound( cas:50501-07-0 ) in New Journal of Chemistry. Keywords: biomass carbon catalyst aerobic dehydrogenation nitrogen heterocycle. We’ll tell you more about this compound (cas:50501-07-0).

N-doped porous carbon (NC) was synthesized from sugar cane bagasse, which is a sustainable and widely available biomass waste. The preferred NC sample had a well-developed porous structure, a graphene-like surface morphol. and different N species. More importantly, the heterogeneous carbocatalyst exhibited superior catalytic performance in the aerobic dehydrogenation of various heterocyclic nitrogen compounds (49 examples, up to 96% yield), similar to that of C3N4 and GO. Characterization by TEM, BET and XPS accompanied by the EPR anal. revealed that the enhanced catalytic properties of NC came from its high activation ability for both O2 and heterocyclic nitrogen, attributed to the porous structure and pyridinic N (N-6) species, resp.

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