Category: 50501-07-0

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 50501-07-0, is researched, SMILESS is O=C(C1NC2=C(C=CC=C2)C1)OCC, Molecular C11H13NO2Journal, Article, Bioorganic & Medicinal Chemistry Letters called Synthesis and antibacterial activity of [6,5,5] and [6,6,5] tricyclic fused oxazolidinones, Author is Gleave, D. Mark; Brickner, Steven J.; Manninen, Peter R.; Allwine, Debra A.; Lovasz, Kristine D.; Rohrer, Douglas C.; Tucker, John A.; Zurenko, Gary E.; Ford, Charles W., the main research direction is oxazolidinone fused conformationally restricted preparation antibacterial.SDS of cas: 50501-07-0.

A series of conformationally restricted, [6,5,5] and [6,6,5] tricyclic fused oxazolidinones were synthesized and tested for antibacterial activity. Several compounds, e.g. I, in the trans-[6,5,5] series demonstrated potent in vitro and in vivo activity. This work provides valuable information regarding the preferred conformational orientation of the oxazolidinones at the binding site.

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Zhong, Jian-Ji; To, Wai-Pong; Liu, Yungen; Lu, Wei; Che, Chi-Ming published the article 《Efficient acceptorless photo-dehydrogenation of alcohols and N-heterocycles with binuclear platinum(II) diphosphite complexes》. Keywords: binuclear platinum diphosphite complex preparation UV absorption; ketone aldehyde preparation; alc photodehydrogenation binuclear platinum diphosphite complex catalyst; indole quinoline isoquinoline benzothiazole pyrrole preparation; saturated heterocycle photodehydrogenation binuclear platinum diphosphite catalyst; quinazolinone preparation; anthranilamide alc tandem dehydrogenation coupling binuclear platinum diphosphite catalyst.They researched the compound: Ethyl indoline-2-carboxylate( cas:50501-07-0 ).Formula: C11H13NO2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:50501-07-0) here.

Binuclear platinum(II) diphosphite complexes as practical and efficient photocatalysts for oxidant-free and acceptorless dehydrogenation of alcs. and N-heterocycles in high yields even under substrate-limiting conditions was described. The reaction could be used for constructing quinazolin-4(3H)-ones from anthranilamide and alcs. This protocol offered the unique reactivity of binuclear platinum(II) diphosphite complexes, wide substrate scope, mild reaction conditions, scalability, utility and versatility of these photocatalysts with practical relevance. Regeneration of the photocatalyst by means of reductive elimination of dihydrogen from the in-situ formed platinum(III)-hydride species represented an alternative paradigm to the current approach in photoredox catalysis.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 50501-07-0, is researched, Molecular C11H13NO2, about Isolation of a Bacillus Aryabhattai strain for the resolution of (R, S)-ethyl indoline-2-carboxylate to produce (S)-indoline-2-carboxylic acid, the main research direction is Bacillus Aryabhattai esterase perindopril.SDS of cas: 50501-07-0.

The strain screened from sludge can selectively hydrolyze (S)-Et indoline-2-carboxylate to produce (S)-indoline-2-carboxylic acid. It was identified as the Bacillus aryabhattai strain based on its morphol., metabolism, and 16S rDNA sequence anal. Glucose and yeast powder were used as the best carbon and nitrogen sources to cultured cells with an initial pH of seven. Subsequently, we optimized the key parameters for selective hydrolysis. Finally, when the substrate concentration had reached 3%, with a 35°C water bath, a pH of seven, and a speed of 600 rpm, the e.e.p value attained 96% with a 33% yield. Thus, we had developed a new method for producing (S)-indoline-2-carboxylic acid that used whole microbial cells as the biocatalyst.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Isolation of a Bacillus Aryabhattai strain for the resolution of (R, S)-ethyl indoline-2-carboxylate to produce (S)-indoline-2-carboxylic acid, published in 2019, which mentions a compound: 50501-07-0, mainly applied to Bacillus Aryabhattai esterase perindopril, Reference of Ethyl indoline-2-carboxylate.

The strain screened from sludge can selectively hydrolyze (S)-Et indoline-2-carboxylate to produce (S)-indoline-2-carboxylic acid. It was identified as the Bacillus aryabhattai strain based on its morphol., metabolism, and 16S rDNA sequence anal. Glucose and yeast powder were used as the best carbon and nitrogen sources to cultured cells with an initial pH of seven. Subsequently, we optimized the key parameters for selective hydrolysis. Finally, when the substrate concentration had reached 3%, with a 35°C water bath, a pH of seven, and a speed of 600 rpm, the e.e.p value attained 96% with a 33% yield. Thus, we had developed a new method for producing (S)-indoline-2-carboxylic acid that used whole microbial cells as the biocatalyst.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Ethyl indoline-2-carboxylate(SMILESS: O=C(C1NC2=C(C=CC=C2)C1)OCC,cas:50501-07-0) is researched.Formula: C16H21O3P. The article 《Study on the synthesis of S-(-)-2-Carboxyindoline》 in relation to this compound, is published in Gaoxiao Huaxue Gongcheng Xuebao. Let’s take a look at the latest research on this compound (cas:50501-07-0).

A general synthetic route of S-(-)-2-carboxyindoline was proposed which started from o-nitrotoluene and di-Et oxalate, via condensation, nitro-group reduction, heterocyclic reduction and hydrolysis, 2-carboxyindoline was achieved with total yield of 40.6%. Especially, using 10% Pd-C as catalysts, the heterocycle is reduced easily with hydrogen at 160° and 6.2 MPa, the catalysts also can be reclaimed. Through steps of chlorination, esterification, fractional crystallization, and hydrolysis, the S-(-)-2-carboxyindoline was resolved with L-carnitine oxalate as the chiral resolution reagent. The titled product can be achieved with 32% yield and [α20589 = -27.5] (c = 1.0, DMSO).

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Ethyl indoline-2-carboxylate(SMILESS: O=C(C1NC2=C(C=CC=C2)C1)OCC,cas:50501-07-0) is researched.Formula: C16H21O3P. The article 《Study on the synthesis of S-(-)-2-Carboxyindoline》 in relation to this compound, is published in Gaoxiao Huaxue Gongcheng Xuebao. Let’s take a look at the latest research on this compound (cas:50501-07-0).

A general synthetic route of S-(-)-2-carboxyindoline was proposed which started from o-nitrotoluene and di-Et oxalate, via condensation, nitro-group reduction, heterocyclic reduction and hydrolysis, 2-carboxyindoline was achieved with total yield of 40.6%. Especially, using 10% Pd-C as catalysts, the heterocycle is reduced easily with hydrogen at 160° and 6.2 MPa, the catalysts also can be reclaimed. Through steps of chlorination, esterification, fractional crystallization, and hydrolysis, the S-(-)-2-carboxyindoline was resolved with L-carnitine oxalate as the chiral resolution reagent. The titled product can be achieved with 32% yield and [α20589 = -27.5] (c = 1.0, DMSO).

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HPLC of Formula: 50501-07-0. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Ethyl indoline-2-carboxylate, is researched, Molecular C11H13NO2, CAS is 50501-07-0, about Computational analysis of chiral recognition in Pirkle phases.

The relative retention orders and chromatog. separability factors for optical analytes on 2 com. available chiral stationary phases have been determined from statistical mol. modeling. The intermmol. potential-energy surfaces of the diastereomeric complexes formed between the chiral receptor and mirror image substrates are flat and reveal that both enantiomers tend to dock in the same general region around the receptor. How the receptor senses differences between mirror image analytes (enantiorecognition) is revealed with an algorithm that partitions the total binding energy into mol. fragments on the receptor. The fragments on the receptor most responsible for substrate binding are located and the fragments most responsible for enantioselection are discovered. The fragment bearing the stereogenic centers is generally not the most cognizant of differences between mirror image substrates, and the results are generally in agreement with previously proposed chiral recognition models.

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Electric Literature of C11H13NO2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Ethyl indoline-2-carboxylate, is researched, Molecular C11H13NO2, CAS is 50501-07-0, about Regiospecific functionalization of indole-2-carboxylates and diastereoselective preparation of the corresponding indolines. Author is Collot, Valerie; Schmitt, Martine; Marwah, Padma; Bourguignon, Jean-Jacques.

The N-acyl derivatives of 3-substituted indole-2-carboxylates prepared through several routes were submitted to catalytic hydrogenation affording either cis- or trans-indoline diastereomers after quant. C-2 epimerization.

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Safety of Ethyl indoline-2-carboxylate. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Ethyl indoline-2-carboxylate, is researched, Molecular C11H13NO2, CAS is 50501-07-0, about Room temperature catalytic dehydrogenation of cyclic amines with the liberation of H2 using water as a solvent. Author is Sahoo, Manoj K.; Balaraman, Ekambaram.

Catalytic dehydrogenation of cyclic amines, in particular partially saturated N-heterocycles to N-heterocyclic arenes, quinolines, indolines and quinoxalines with the removal of mol. hydrogen as the sole byproduct in water was reported. This dehydrogenation reaction proceeded smoothly under very mild and benign conditions and operates at room temperature This distinctive reactivity was achieved under dual catalytic conditions by merging the visible-light active [Ru(bpy)3]2+ as the photoredox catalyst and a newly synthesized cobalt complex as the proton-reduction catalyst. A detailed mechanistic study (control experiments, electrochem. studies, UV-visible experiments) was presented for the present dual catalysis.

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Ethyl indoline-2-carboxylate, is researched, Molecular C11H13NO2, CAS is 50501-07-0, about Synthesis of Azoles Condensed with, or Linked to, Nitroxides, the main research direction is nitroxide pyrrole pyrazole triazole pyridine indole radical preparation.Name: Ethyl indoline-2-carboxylate.

Nitroxides connected to indoles, tetrazoles or 1,3,4-oxadiazoles were synthesized by conventional and microwave-assisted cyclization reactions. New approaches to pyrrole-, pyrazole-, and triazole-annulated nitroxides are described. The authors showed that a Diels-Alder reaction of a N-tert-butoxycarbonyl derivative of (4,4,6,6-tetramethyl-2,4,6,7-tetrahydro-5H-pyrrolo[3,4-c]pyridin-5-yl)oxidanyl gave polycyclic scaffolds condensed with a six-membered nitroxide. The synthesis of the target compounds was achieved using as starting materials 3-cyano-2,5-dihydro-2,2,5,5-tetramethyl-1H-pyrrol-1-yloxy radical, 4-cyano-3,6-dihydro-2,2,6,6-tetramethyl-1(2H)-pyridinyloxy radical, 4-cyano-2,2,6,6-tetramethyl-1-piperidinyloxy radical (TEMPO derivative), 3-formyl-2,5-dihydro-2,2,5,5-tetramethyl-1H-pyrrol-1-yloxy radical and similar nitroxide radical derivatives The title compounds thus formed included triazole-nitroxide radical derivatives, benzotriazole-nitroxide radical derivatives, pyrrole-nitroxide radical derivatives, indole-nitroxide radical derivatives and related substances.

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