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Application In Synthesis of Ethyl indoline-2-carboxylate. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Ethyl indoline-2-carboxylate, is researched, Molecular C11H13NO2, CAS is 50501-07-0, about Introduction of heterocycles at the 2-position of indoline as ester bioisosteres. Author is Lee, Sunkyung; Yi, Kyu Yang; Yoo, Sung-eun.

Compounds were prepared with heterocyclic replacements for metabolically unstable esters of benzopyranyl indole-2-carboxylic esters, which showed good in vitro and in vivo cardioprotective efficacies possibly through the opening of mitochondrial ATP-sensitive potassium channel (KATP). Initially, indolin-2-yl-heterocycles were constructed using unprotected indoline-2-carboxylic acid, but the cyclization was proceeded with oxidation of the indoline ring to the indole, which did not react with benzopyranyl epoxide. An N-BOC group was introduced to deplete the electron d. of the indoline ring. Various indolin-2-yl-heterocycles, such as I and II, were prepared by the cyclization of the building blocks including carboxamide, β-hydroxy amide, hydrazide, nitrile starting from N-BOC-indoline-2-carboxylic acid.

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Application of 50501-07-0. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Ethyl indoline-2-carboxylate, is researched, Molecular C11H13NO2, CAS is 50501-07-0, about Reusable, homogeneous water soluble photoredox catalyzed oxidative dehydrogenation of N-heterocycles in a biphasic system: application to the synthesis of biologically active natural products. Author is Srinath, S.; Abinaya, R.; Prasanth, Arun; Mariappan, M.; Sridhar, R.; Baskar, B..

A simple and efficient method for the oxidative dehydrogenation (ODH) of partially saturated N-heterocycles (indolines, tetrahydro-β-carbolines and tetrahydro(iso)quinolines) e.g., I is described using a reusable, homogeneous cobalt-phthalocyanine photoredox catalyst II (R = SO3Na; M = Co) in a biphasic medium. A biphasic system offers an advantage of easy separation of the product and an efficient reusability of the homogeneous photoredox catalyst. Also, the current system significantly helps to overcome the solubility issue of the substrate and catalyst at room temperature Its potential applications to organic transformations are demonstrated by the synthesis of various biol. active N-heterocycles (indoles, β-carbolines, (iso)quinolines) e.g., III and natural products such as eudistomin U, norharmane, and harmane and precursors to perlolyrine and flazin. Without isolation and purification, the catalyst solution can be reused up to 5 times with almost comparable reactivity. Furthermore, the efficiency of the reaction was demonstrated on a gram scale. To the best of our knowledge, this is the first report on ODH reactions using a non noble, reusable and homogeneous cobalt photoredox catalyst under environmentally friendly conditions.

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Brief introduction of 50501-07-0

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Zhong, Jian-Ji; To, Wai-Pong; Liu, Yungen; Lu, Wei; Che, Chi-Ming published the article 《Efficient acceptorless photo-dehydrogenation of alcohols and N-heterocycles with binuclear platinum(II) diphosphite complexes》. Keywords: binuclear platinum diphosphite complex preparation UV absorption; ketone aldehyde preparation; alc photodehydrogenation binuclear platinum diphosphite complex catalyst; indole quinoline isoquinoline benzothiazole pyrrole preparation; saturated heterocycle photodehydrogenation binuclear platinum diphosphite catalyst; quinazolinone preparation; anthranilamide alc tandem dehydrogenation coupling binuclear platinum diphosphite catalyst.They researched the compound: Ethyl indoline-2-carboxylate( cas:50501-07-0 ).Quality Control of Ethyl indoline-2-carboxylate. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:50501-07-0) here.

Binuclear platinum(II) diphosphite complexes as practical and efficient photocatalysts for oxidant-free and acceptorless dehydrogenation of alcs. and N-heterocycles in high yields even under substrate-limiting conditions was described. The reaction could be used for constructing quinazolin-4(3H)-ones from anthranilamide and alcs. This protocol offered the unique reactivity of binuclear platinum(II) diphosphite complexes, wide substrate scope, mild reaction conditions, scalability, utility and versatility of these photocatalysts with practical relevance. Regeneration of the photocatalyst by means of reductive elimination of dihydrogen from the in-situ formed platinum(III)-hydride species represented an alternative paradigm to the current approach in photoredox catalysis.

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Interesting scientific research on 50501-07-0

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Zhang, Yinjun; Chen, Jialin; Chen, Changsheng; Wu, Shijin published an article about the compound: Ethyl indoline-2-carboxylate( cas:50501-07-0,SMILESS:O=C(C1NC2=C(C=CC=C2)C1)OCC ).COA of Formula: C11H13NO2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:50501-07-0) through the article.

The strain screened from sludge can selectively hydrolyze (S)-Et indoline-2-carboxylate to produce (S)-indoline-2-carboxylic acid. It was identified as the Bacillus aryabhattai strain based on its morphol., metabolism, and 16S rDNA sequence anal. Glucose and yeast powder were used as the best carbon and nitrogen sources to cultured cells with an initial pH of seven. Subsequently, we optimized the key parameters for selective hydrolysis. Finally, when the substrate concentration had reached 3%, with a 35°C water bath, a pH of seven, and a speed of 600 rpm, the e.e.p value attained 96% with a 33% yield. Thus, we had developed a new method for producing (S)-indoline-2-carboxylic acid that used whole microbial cells as the biocatalyst.

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Extracurricular laboratory: Synthetic route of 50501-07-0

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 50501-07-0, is researched, SMILESS is O=C(C1NC2=C(C=CC=C2)C1)OCC, Molecular C11H13NO2Journal, Article, Research Support, Non-U.S. Gov’t, European Journal of Medicinal Chemistry called Cardioselective anti-ischemic ATP-sensitive potassium channel (KATP) openers: benzopyranyl indoline and indole analogues, Author is Lee, Sunkyung; Yi, Kyu Yang; Kim, Soo-Kyung; Suh, Jeehee; Kim, Nak Jeong; Yoo, Sung-Eun; Lee, Byung Ho; Seo, Ho Won; Kim, Sun-Ok; Lim, Hong, the main research direction is benzopyranyl indoline indole analog preparation cardioprotective activity; antiischemic ATP sensitive potassium channel opener benzopyranyl indoline; structure activity relationship benzopyranyl indoline indole analog; conformation benzopyranyl indoline indole analog crystal structure.Recommanded Product: 50501-07-0.

This paper describes the design, syntheses, and biol. evaluations of novel ATP-sensitive potassium channel (KATP) openers, benzopyranyl indoline and indole derivatives Among those, two enantiomers of indoline-2-carboxylic Et esters (14, 18) showed the best cardioprotective activities both in vitro and in vivo, while their vasorelaxation potencies were very low (concentration for 50% inhibition of vasorelaxation >30 μM). The cardioprotective effect of 14 was completely reversed by 5-hydroxydecanoate, a selective mitochondrial KATP blocker, indicating its provable protective mechanism through the mitochondrial KATP opening. In addition, we performed conformational analyses using 2D-NMR, X-ray crystallog. and mol. modeling to study the structure-activity relationships in this series of compounds

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Introduction of a new synthetic route about 50501-07-0

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Ethyl indoline-2-carboxylate, is researched, Molecular C11H13NO2, CAS is 50501-07-0, about A Reusable Cobalt Catalyst for Reversible Acceptorless Dehydrogenation and Hydrogenation of N-Heterocycles, the main research direction is cobalt complex preparation surface structure; azaarene cobalt complex catalyst dehydrogenation; nitrogen heterocycle compound cobalt complex catalyst hydrogenation.Quality Control of Ethyl indoline-2-carboxylate.

A highly efficient reusable cobalt-based heterogeneous catalyst for reversible dehydrogenation and hydrogenation of N-heterocycles was repoted. Both the acceptorless dehydrogenation (ADH) and the hydrogenation processes operated under mild and benign conditions.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Ethyl indoline-2-carboxylate(SMILESS: O=C(C1NC2=C(C=CC=C2)C1)OCC,cas:50501-07-0) is researched.Formula: C15H11NO. The article 《Study on the synthesis of S-(-)-2-Carboxyindoline》 in relation to this compound, is published in Gaoxiao Huaxue Gongcheng Xuebao. Let’s take a look at the latest research on this compound (cas:50501-07-0).

A general synthetic route of S-(-)-2-carboxyindoline was proposed which started from o-nitrotoluene and di-Et oxalate, via condensation, nitro-group reduction, heterocyclic reduction and hydrolysis, 2-carboxyindoline was achieved with total yield of 40.6%. Especially, using 10% Pd-C as catalysts, the heterocycle is reduced easily with hydrogen at 160° and 6.2 MPa, the catalysts also can be reclaimed. Through steps of chlorination, esterification, fractional crystallization, and hydrolysis, the S-(-)-2-carboxyindoline was resolved with L-carnitine oxalate as the chiral resolution reagent. The titled product can be achieved with 32% yield and [α20589 = -27.5] (c = 1.0, DMSO).

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Formula: C11H13NO2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Ethyl indoline-2-carboxylate, is researched, Molecular C11H13NO2, CAS is 50501-07-0, about Convenient synthesis of dioxopiperazines via aminolysis of α-(pyruvylamino) esters. Author is Marshall, J. A.; Schlaf, T. F.; Csernansky, J. G..

Dioxopiperazines I and II were prepared from indoline III by cyclizing with MeNH2 to give dioxopiperazine IV, which was dehydrated to methylene compound V. V added AcSH to give I and II. Analogous reactions starting with pyrrole VI gave dioxopiperazine VII.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 50501-07-0, is researched, SMILESS is O=C(C1NC2=C(C=CC=C2)C1)OCC, Molecular C11H13NO2Journal, Green Chemistry called Reusable, homogeneous water soluble photoredox catalyzed oxidative dehydrogenation of N-heterocycles in a biphasic system: application to the synthesis of biologically active natural products, Author is Srinath, S.; Abinaya, R.; Prasanth, Arun; Mariappan, M.; Sridhar, R.; Baskar, B., the main research direction is pyridoindole preparation green chem; tetrahydropyridoindole oxidative dehydrogenation cobalt phthalocyanine photoredox reusable catalyst; quinoline preparation green chem; tetrahydroquinoline oxidative dehydrogenation cobalt phthalocyanine photoredox reusable catalyst; isoquinoline preparation green chem; tetrahydroisoquinoline oxidative dehydrogenation cobalt phthalocyanine photoredox reusable catalyst; indole preparation green chem; indoline oxidative dehydrogenation cobalt phthalocyanine photoredox reusable catalyst.Application of 50501-07-0.

A simple and efficient method for the oxidative dehydrogenation (ODH) of partially saturated N-heterocycles (indolines, tetrahydro-β-carbolines and tetrahydro(iso)quinolines) e.g., I is described using a reusable, homogeneous cobalt-phthalocyanine photoredox catalyst II (R = SO3Na; M = Co) in a biphasic medium. A biphasic system offers an advantage of easy separation of the product and an efficient reusability of the homogeneous photoredox catalyst. Also, the current system significantly helps to overcome the solubility issue of the substrate and catalyst at room temperature Its potential applications to organic transformations are demonstrated by the synthesis of various biol. active N-heterocycles (indoles, β-carbolines, (iso)quinolines) e.g., III and natural products such as eudistomin U, norharmane, and harmane and precursors to perlolyrine and flazin. Without isolation and purification, the catalyst solution can be reused up to 5 times with almost comparable reactivity. Furthermore, the efficiency of the reaction was demonstrated on a gram scale. To the best of our knowledge, this is the first report on ODH reactions using a non noble, reusable and homogeneous cobalt photoredox catalyst under environmentally friendly conditions.

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Safety of Ethyl indoline-2-carboxylate. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Ethyl indoline-2-carboxylate, is researched, Molecular C11H13NO2, CAS is 50501-07-0, about Regiospecific functionalization of indole-2-carboxylates and diastereoselective preparation of the corresponding indolines. Author is Collot, Valerie; Schmitt, Martine; Marwah, Padma; Bourguignon, Jean-Jacques.

The N-acyl derivatives of 3-substituted indole-2-carboxylates prepared through several routes were submitted to catalytic hydrogenation affording either cis- or trans-indoline diastereomers after quant. C-2 epimerization.

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