Category: 50501-07-0

Kim, Dong H.; Guinosso, Charles J.; Buzby, George C. Jr.; Herbst, David R.; McCaully, Ronald J.; Wicks, Thomas C.; Wendt, Robert L. published an article about the compound: Ethyl indoline-2-carboxylate( cas:50501-07-0,SMILESS:O=C(C1NC2=C(C=CC=C2)C1)OCC ).Formula: C11H13NO2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:50501-07-0) through the article.

Stereoisomers of 1-(3-mercapto-2-methyl-1-oxopropyl)indoline-2-carboxylic acid (I) and related compounds were synthesized and their ability to inhibit angiotensin converting enzyme (ACE) [9015-82-1] and to lower the systolic blood pressure of spontaneously hypertensive rats (SHR) examined All 4 possible stereoisomers of the precursor 1-[3-(benzoylthio)-2-methyl-1-oxopropyl]indoline-2-carboxylic acid were characterized with absolute stereochem. assignment. The removal of the benzoyl group of the precursor showed in vitro ACE inhibitory activity; the stereoisomer having the R,R configuration was essentially inactive. The mercaptan (S,S)-I was the most active ACE inhibitor, showing in vitro potency 3 times that of captopril. (S,S)-I exhibited oral antihypertensive activity 27 times that of captopril. The thio lactone obtained by cyclization of (S,S)-I as a potential prodrug was less potent than the parent compound in the ACE inhibitory and antihypertensive tests. Structure-activity relations are discussed.

There is still a lot of research devoted to this compound(SMILES：O=C(C1NC2=C(C=CC=C2)C1)OCC)Formula: C11H13NO2, and with the development of science, more effects of this compound(50501-07-0) can be discovered.

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Computed Properties of C11H13NO2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Ethyl indoline-2-carboxylate, is researched, Molecular C11H13NO2, CAS is 50501-07-0, about Stereochemically Rich Polycyclic Amines from the Kinetic Resolution of Indolines through Intramolecular Povarov Reactions. Author is Min, Chang; Seidel, Daniel.

Under control of a chiral Bronsted acid catalyst, racemic indolines I (R1 = H, 4-Me, 5-Br, 5-F, 5-MeO; R2 = Me, EtO2C, Ph, 4-MeOC6H4, etc.) underwent intramol. Povarov reactions with achiral aromatic aldehydes II (R3 = Ph, 3-ClC6H4, 4-MeC6H4, 1-naphthyl, etc.; R4 = H, 5-Br, 3-MeO, etc.) bearing a pendent dienophile. One enantiomer of the indoline reacted preferentially, resulting in the highly enantio- and diastereoselective formation of polycyclic heterocycles III with four stereogenic centers. This kinetic resolution approach exploits the differential formation/reactivity of diastereomeric ion pairs.

There is still a lot of research devoted to this compound(SMILES：O=C(C1NC2=C(C=CC=C2)C1)OCC)Computed Properties of C11H13NO2, and with the development of science, more effects of this compound(50501-07-0) can be discovered.

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Srinath, S.; Abinaya, R.; Prasanth, Arun; Mariappan, M.; Sridhar, R.; Baskar, B. published the article 《Reusable, homogeneous water soluble photoredox catalyzed oxidative dehydrogenation of N-heterocycles in a biphasic system: application to the synthesis of biologically active natural products》. Keywords: pyridoindole preparation green chem; tetrahydropyridoindole oxidative dehydrogenation cobalt phthalocyanine photoredox reusable catalyst; quinoline preparation green chem; tetrahydroquinoline oxidative dehydrogenation cobalt phthalocyanine photoredox reusable catalyst; isoquinoline preparation green chem; tetrahydroisoquinoline oxidative dehydrogenation cobalt phthalocyanine photoredox reusable catalyst; indole preparation green chem; indoline oxidative dehydrogenation cobalt phthalocyanine photoredox reusable catalyst.They researched the compound: Ethyl indoline-2-carboxylate( cas:50501-07-0 ).HPLC of Formula: 50501-07-0. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:50501-07-0) here.

A simple and efficient method for the oxidative dehydrogenation (ODH) of partially saturated N-heterocycles (indolines, tetrahydro-β-carbolines and tetrahydro(iso)quinolines) e.g., I is described using a reusable, homogeneous cobalt-phthalocyanine photoredox catalyst II (R = SO3Na; M = Co) in a biphasic medium. A biphasic system offers an advantage of easy separation of the product and an efficient reusability of the homogeneous photoredox catalyst. Also, the current system significantly helps to overcome the solubility issue of the substrate and catalyst at room temperature Its potential applications to organic transformations are demonstrated by the synthesis of various biol. active N-heterocycles (indoles, β-carbolines, (iso)quinolines) e.g., III and natural products such as eudistomin U, norharmane, and harmane and precursors to perlolyrine and flazin. Without isolation and purification, the catalyst solution can be reused up to 5 times with almost comparable reactivity. Furthermore, the efficiency of the reaction was demonstrated on a gram scale. To the best of our knowledge, this is the first report on ODH reactions using a non noble, reusable and homogeneous cobalt photoredox catalyst under environmentally friendly conditions.

There is still a lot of research devoted to this compound(SMILES：O=C(C1NC2=C(C=CC=C2)C1)OCC)HPLC of Formula: 50501-07-0, and with the development of science, more effects of this compound(50501-07-0) can be discovered.

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Application In Synthesis of Ethyl indoline-2-carboxylate. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Ethyl indoline-2-carboxylate, is researched, Molecular C11H13NO2, CAS is 50501-07-0, about Synthesis and substitution of 1,3,4,6-tetra-substituted-3,6-dihalo-2,5-piperazinediones. Author is Yoshimura, Juji; Sugiyama, Yuichi; Nakamura, Hiroshi.

Addition of Cl to 3,6-dimethylene- (I) and 3,6-dibenzylidene-1,4-dimethyl-2,5-piperazinediones gave isomers of the corresponding tetrachloride, e.g., II, and substitution of 1,3,4,6-tetramethyl-2,5-piperazinedione with Br also gave a tetrabromide III of the same type via successive elimination and addition reactions. Treatment of III with water and with methanolic NaOAc gave the corresponding 3,6-dihydroxy and dimethoxy derivatives, resp., while treatment with NaI, Na2S, NaSCN, or NaOSCMe gave only I and S in a good yield. Similar results were obtained in the case of octahydro-5H,10H-dipyrrolo[1,2-a:1′,2′-d]pyrazine-5,10-dione. However, bromination of 6,13-dioxo-6a,7,13a,14-tetrahydro-6H,13H-pyrazino[1,2-a:4,5-a’]diindole gave rise only to aromatization. Configurations of the isomers obtained and the reaction processes were discussed.

There is still a lot of research devoted to this compound(SMILES：O=C(C1NC2=C(C=CC=C2)C1)OCC)Application In Synthesis of Ethyl indoline-2-carboxylate, and with the development of science, more effects of this compound(50501-07-0) can be discovered.

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 50501-07-0, is researched, SMILESS is O=C(C1NC2=C(C=CC=C2)C1)OCC, Molecular C11H13NO2Journal, Article, Bioorganic & Medicinal Chemistry Letters called Synthesis and antibacterial activity of [6,5,5] and [6,6,5] tricyclic fused oxazolidinones, Author is Gleave, D. Mark; Brickner, Steven J.; Manninen, Peter R.; Allwine, Debra A.; Lovasz, Kristine D.; Rohrer, Douglas C.; Tucker, John A.; Zurenko, Gary E.; Ford, Charles W., the main research direction is oxazolidinone fused conformationally restricted preparation antibacterial.Recommanded Product: 50501-07-0.

A series of conformationally restricted, [6,5,5] and [6,6,5] tricyclic fused oxazolidinones were synthesized and tested for antibacterial activity. Several compounds, e.g. I, in the trans-[6,5,5] series demonstrated potent in vitro and in vivo activity. This work provides valuable information regarding the preferred conformational orientation of the oxazolidinones at the binding site.

There is still a lot of research devoted to this compound(SMILES：O=C(C1NC2=C(C=CC=C2)C1)OCC)Recommanded Product: 50501-07-0, and with the development of science, more effects of this compound(50501-07-0) can be discovered.

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Ethyl indoline-2-carboxylate, is researched, Molecular C11H13NO2, CAS is 50501-07-0, about Chromatographic separation of the enantiomers of 2-carboalkoxyindolines and N-aryl-α-amino esters on chiral stationary phases derived from N-(3,5-dinitrobenzoyl)-α-amino acids, the main research direction is resolution aryl amino ester carbalkoxyindoline; aryl amino acid ester resolution; carbalkoxyindoline resolution chromatog chiral phase; indoline carbalkoxy resolution chiral chromatog; chromatog chiral stationary phase solution; nitrobenzoyl amino acid chiral phase.HPLC of Formula: 50501-07-0.

The enantiomers of N-acyl amino acid esters RNHCHR1CO2R2 (R = Ph, 1- or 2-naphthyl, 2-anthryl; R1 = Ph, Me, Et, etc.; R2 = Et, Me, etc.) and 2-carboalkoxyindolines I (R3 = R4 = H, R3 = 5-Me, R4 = 6-Me; R3 = 5-MeO, R4 = H; R3R4 = 4,5-benzo, 6,7-benzo) were separated by column chromatog. on chiral stationary phases prepared from N-(3,5-dinitrobenzoyl) derivatives of (S)-leucine or (R)-phenylglycine. The degree of chiral recognition was high. Separation factors >10 were obtained and preparative separations were performed. A chiral recognition model is presented.

There is still a lot of research devoted to this compound(SMILES：O=C(C1NC2=C(C=CC=C2)C1)OCC)HPLC of Formula: 50501-07-0, and with the development of science, more effects of this compound(50501-07-0) can be discovered.

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Name: Ethyl indoline-2-carboxylate. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Ethyl indoline-2-carboxylate, is researched, Molecular C11H13NO2, CAS is 50501-07-0, about Synthesis and biological activity of alkyl-2-[5-(hydroxy-methyl)-5-nitro-2-oxo-1,3,2λ5-dioxaphosphinan-2-yl] amino acid esters.

Synthesis of a series of new alkyl-2-[5-(hydroxymethyl)-5-nitro-2-oxo-1,3,2λ5-dioxaphosphinan-2-yl] amino acid esters was accomplished through a two-step process. The key step in the synthesis involves preparation of a dichloride intermediate, with different amino acid esters and with a few substituted phenols by reacting POCl3 in presence of Et3N in THF at 0-15°C. In the second step the intermediate in situ is treated with tris(hydroxymethyl)nitromethane (2-hydroxymethyl-2-nitro-1,3-propanediol) in the presence of Et3N at 40-45°C to form final products. The structures of final products were established by elemental anal., IR, 1H, 13C and 31P NMR and mass spectral data. The antimicrobial activity of these compounds was evaluated and they exhibited moderate antifungal and antibacterial activities.

If you want to learn more about this compound(Ethyl indoline-2-carboxylate)Name: Ethyl indoline-2-carboxylate, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(50501-07-0).

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Asymmetric synthesis of α-amino acids. I. A new approach, published in 1970, which mentions a compound: 50501-07-0, Name is Ethyl indoline-2-carboxylate, Molecular C11H13NO2, Name: Ethyl indoline-2-carboxylate.

Asymmetric synthesis of α-amino acids from α-keto acids using chiral reagents which are regenerated by the synthesis is described. The chiral reagents used were N-amino-2-hydroxymethylindolines (I). The synthesis, resolution, and assignment of absolute configuration for these reagents is described. The application of (I) to the asymmetric synthesis of α-amino acids depends on their combination with α-keto acids to form chiral hydrazono lactones. Reduction of the C:N unit in these lactones affords the corresponding hydrazino lactones which are transformed to α-amino acids by hydrogenolysis of the N-N linkage and ester hydrolysis. By this process D-alanine and D-butyrine were synthesized from pyruvic acid and α-oxobutyric acid in optical purities of 80 and 90%, resp. A solid basis exists for the design of chiral indoline reagents of still greater efficiency in the asymmetric synthesis of α-amino acids.

If you want to learn more about this compound(Ethyl indoline-2-carboxylate)Name: Ethyl indoline-2-carboxylate, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(50501-07-0).

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Recommanded Product: Ethyl indoline-2-carboxylate. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Ethyl indoline-2-carboxylate, is researched, Molecular C11H13NO2, CAS is 50501-07-0, about Asymmetric synthesis of α-amino acids. I. A new approach. Author is Corey, Elias J.; McCaully, Ronald J.; Sachdev, Harbans S..

Asymmetric synthesis of α-amino acids from α-keto acids using chiral reagents which are regenerated by the synthesis is described. The chiral reagents used were N-amino-2-hydroxymethylindolines (I). The synthesis, resolution, and assignment of absolute configuration for these reagents is described. The application of (I) to the asymmetric synthesis of α-amino acids depends on their combination with α-keto acids to form chiral hydrazono lactones. Reduction of the C:N unit in these lactones affords the corresponding hydrazino lactones which are transformed to α-amino acids by hydrogenolysis of the N-N linkage and ester hydrolysis. By this process D-alanine and D-butyrine were synthesized from pyruvic acid and α-oxobutyric acid in optical purities of 80 and 90%, resp. A solid basis exists for the design of chiral indoline reagents of still greater efficiency in the asymmetric synthesis of α-amino acids.

If you want to learn more about this compound(Ethyl indoline-2-carboxylate)Recommanded Product: Ethyl indoline-2-carboxylate, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(50501-07-0).

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Application of 50501-07-0. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Ethyl indoline-2-carboxylate, is researched, Molecular C11H13NO2, CAS is 50501-07-0, about Study on the synthesis of S-(-)-2-Carboxyindoline. Author is Qian, Chao; Zhang, Jia-sen; Liu, Jian-qing; Li, Lu-zhen; Chen, Xin-zhi.

A general synthetic route of S-(-)-2-carboxyindoline was proposed which started from o-nitrotoluene and di-Et oxalate, via condensation, nitro-group reduction, heterocyclic reduction and hydrolysis, 2-carboxyindoline was achieved with total yield of 40.6%. Especially, using 10% Pd-C as catalysts, the heterocycle is reduced easily with hydrogen at 160° and 6.2 MPa, the catalysts also can be reclaimed. Through steps of chlorination, esterification, fractional crystallization, and hydrolysis, the S-(-)-2-carboxyindoline was resolved with L-carnitine oxalate as the chiral resolution reagent. The titled product can be achieved with 32% yield and [α20589 = -27.5] (c = 1.0, DMSO).

If you want to learn more about this compound(Ethyl indoline-2-carboxylate)Application of 50501-07-0, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(50501-07-0).

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics