Category: 50501-07-0

Category: tetrahydropyran. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Ethyl indoline-2-carboxylate, is researched, Molecular C11H13NO2, CAS is 50501-07-0, about Chromatographic separation of the enantiomers of 2-carboalkoxyindolines and N-aryl-α-amino esters on chiral stationary phases derived from N-(3,5-dinitrobenzoyl)-α-amino acids. Author is Pirkle, William H.; Pochapsky, Thomas C.; Mahler, George S.; Field, Richard E..

The enantiomers of N-acyl amino acid esters RNHCHR1CO2R2 (R = Ph, 1- or 2-naphthyl, 2-anthryl; R1 = Ph, Me, Et, etc.; R2 = Et, Me, etc.) and 2-carboalkoxyindolines I (R3 = R4 = H, R3 = 5-Me, R4 = 6-Me; R3 = 5-MeO, R4 = H; R3R4 = 4,5-benzo, 6,7-benzo) were separated by column chromatog. on chiral stationary phases prepared from N-(3,5-dinitrobenzoyl) derivatives of (S)-leucine or (R)-phenylglycine. The degree of chiral recognition was high. Separation factors >10 were obtained and preparative separations were performed. A chiral recognition model is presented.

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HPLC of Formula: 50501-07-0. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Ethyl indoline-2-carboxylate, is researched, Molecular C11H13NO2, CAS is 50501-07-0, about (Mercaptopropanoyl)indoline-2-carboxylic acids and related compounds as potent angiotensin converting enzyme inhibitors and antihypertensive agents. Author is Kim, Dong H.; Guinosso, Charles J.; Buzby, George C. Jr.; Herbst, David R.; McCaully, Ronald J.; Wicks, Thomas C.; Wendt, Robert L..

Stereoisomers of 1-(3-mercapto-2-methyl-1-oxopropyl)indoline-2-carboxylic acid (I) and related compounds were synthesized and their ability to inhibit angiotensin converting enzyme (ACE) [9015-82-1] and to lower the systolic blood pressure of spontaneously hypertensive rats (SHR) examined All 4 possible stereoisomers of the precursor 1-[3-(benzoylthio)-2-methyl-1-oxopropyl]indoline-2-carboxylic acid were characterized with absolute stereochem. assignment. The removal of the benzoyl group of the precursor showed in vitro ACE inhibitory activity; the stereoisomer having the R,R configuration was essentially inactive. The mercaptan (S,S)-I was the most active ACE inhibitor, showing in vitro potency 3 times that of captopril. (S,S)-I exhibited oral antihypertensive activity 27 times that of captopril. The thio lactone obtained by cyclization of (S,S)-I as a potential prodrug was less potent than the parent compound in the ACE inhibitory and antihypertensive tests. Structure-activity relations are discussed.

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Ertugrul, Berrak; Kilic, Haydar; Lafzi, Farrokh; Saracoglu, Nurullah published an article about the compound: Ethyl indoline-2-carboxylate( cas:50501-07-0,SMILESS:O=C(C1NC2=C(C=CC=C2)C1)OCC ).Safety of Ethyl indoline-2-carboxylate. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:50501-07-0) through the article.

A straightforward synthetic route toward C5-alkylated indolines/indoles has been developed. The strategy is composed of Zn(OTf)2-catalyzed Friedel-Crafts alkylation of N-benzylindolines with nitroolefins, and a series of diverse indolines was first obtained in up to 99% yield. This reaction provides a direct and practical route to a variety of the C5-alkylated indolines which were also utilized for accessing corresponding indoles. Indoline derivatives with free NH groups could be obtained through an N-deprotection reaction. Moreover, the primary alkyl nitro groups in both indolines and indoles are amenable to further synthetic elaborations, thereby broadening the diversity of the products.

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Lee, Sunkyung; Yi, Kyu Yang; Kim, Soo-Kyung; Suh, Jeehee; Kim, Nak Jeong; Yoo, Sung-Eun; Lee, Byung Ho; Seo, Ho Won; Kim, Sun-Ok; Lim, Hong published an article about the compound: Ethyl indoline-2-carboxylate( cas:50501-07-0,SMILESS:O=C(C1NC2=C(C=CC=C2)C1)OCC ).Application In Synthesis of Ethyl indoline-2-carboxylate. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:50501-07-0) through the article.

This paper describes the design, syntheses, and biol. evaluations of novel ATP-sensitive potassium channel (KATP) openers, benzopyranyl indoline and indole derivatives Among those, two enantiomers of indoline-2-carboxylic Et esters (14, 18) showed the best cardioprotective activities both in vitro and in vivo, while their vasorelaxation potencies were very low (concentration for 50% inhibition of vasorelaxation >30 μM). The cardioprotective effect of 14 was completely reversed by 5-hydroxydecanoate, a selective mitochondrial KATP blocker, indicating its provable protective mechanism through the mitochondrial KATP opening. In addition, we performed conformational analyses using 2D-NMR, X-ray crystallog. and mol. modeling to study the structure-activity relationships in this series of compounds

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Lee, Sunkyung; Yi, Kyu Yang; Kim, Soo-Kyung; Suh, Jeehee; Kim, Nak Jeong; Yoo, Sung-Eun; Lee, Byung Ho; Seo, Ho Won; Kim, Sun-Ok; Lim, Hong researched the compound: Ethyl indoline-2-carboxylate( cas:50501-07-0 ).Recommanded Product: Ethyl indoline-2-carboxylate.They published the article 《Cardioselective anti-ischemic ATP-sensitive potassium channel (KATP) openers: benzopyranyl indoline and indole analogues》 about this compound( cas:50501-07-0 ) in European Journal of Medicinal Chemistry. Keywords: benzopyranyl indoline indole analog preparation cardioprotective activity; antiischemic ATP sensitive potassium channel opener benzopyranyl indoline; structure activity relationship benzopyranyl indoline indole analog; conformation benzopyranyl indoline indole analog crystal structure. We’ll tell you more about this compound (cas:50501-07-0).

This paper describes the design, syntheses, and biol. evaluations of novel ATP-sensitive potassium channel (KATP) openers, benzopyranyl indoline and indole derivatives Among those, two enantiomers of indoline-2-carboxylic Et esters (14, 18) showed the best cardioprotective activities both in vitro and in vivo, while their vasorelaxation potencies were very low (concentration for 50% inhibition of vasorelaxation >30 μM). The cardioprotective effect of 14 was completely reversed by 5-hydroxydecanoate, a selective mitochondrial KATP blocker, indicating its provable protective mechanism through the mitochondrial KATP opening. In addition, we performed conformational analyses using 2D-NMR, X-ray crystallog. and mol. modeling to study the structure-activity relationships in this series of compounds

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Tetrahydropyran – Wikipedia,
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Name: Ethyl indoline-2-carboxylate. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Ethyl indoline-2-carboxylate, is researched, Molecular C11H13NO2, CAS is 50501-07-0, about Study on the synthesis of S-(-)-2-Carboxyindoline. Author is Qian, Chao; Zhang, Jia-sen; Liu, Jian-qing; Li, Lu-zhen; Chen, Xin-zhi.

A general synthetic route of S-(-)-2-carboxyindoline was proposed which started from o-nitrotoluene and di-Et oxalate, via condensation, nitro-group reduction, heterocyclic reduction and hydrolysis, 2-carboxyindoline was achieved with total yield of 40.6%. Especially, using 10% Pd-C as catalysts, the heterocycle is reduced easily with hydrogen at 160° and 6.2 MPa, the catalysts also can be reclaimed. Through steps of chlorination, esterification, fractional crystallization, and hydrolysis, the S-(-)-2-carboxyindoline was resolved with L-carnitine oxalate as the chiral resolution reagent. The titled product can be achieved with 32% yield and [α20589 = -27.5] (c = 1.0, DMSO).

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Corey, Elias J.; McCaully, Ronald J.; Sachdev, Harbans S. published the article 《Asymmetric synthesis of α-amino acids. I. A new approach》. Keywords: amino acid via keto acid; keto acid amino acid via.They researched the compound: Ethyl indoline-2-carboxylate( cas:50501-07-0 ).Related Products of 50501-07-0. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:50501-07-0) here.

Asymmetric synthesis of α-amino acids from α-keto acids using chiral reagents which are regenerated by the synthesis is described. The chiral reagents used were N-amino-2-hydroxymethylindolines (I). The synthesis, resolution, and assignment of absolute configuration for these reagents is described. The application of (I) to the asymmetric synthesis of α-amino acids depends on their combination with α-keto acids to form chiral hydrazono lactones. Reduction of the C:N unit in these lactones affords the corresponding hydrazino lactones which are transformed to α-amino acids by hydrogenolysis of the N-N linkage and ester hydrolysis. By this process D-alanine and D-butyrine were synthesized from pyruvic acid and α-oxobutyric acid in optical purities of 80 and 90%, resp. A solid basis exists for the design of chiral indoline reagents of still greater efficiency in the asymmetric synthesis of α-amino acids.

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Tetrahydropyran – Wikipedia,
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Recommanded Product: 50501-07-0. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Ethyl indoline-2-carboxylate, is researched, Molecular C11H13NO2, CAS is 50501-07-0, about Convenient synthesis of dioxopiperazines via aminolysis of α-(pyruvylamino) esters. Author is Marshall, J. A.; Schlaf, T. F.; Csernansky, J. G..

Dioxopiperazines I and II were prepared from indoline III by cyclizing with MeNH2 to give dioxopiperazine IV, which was dehydrated to methylene compound V. V added AcSH to give I and II. Analogous reactions starting with pyrrole VI gave dioxopiperazine VII.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 50501-07-0, is researched, SMILESS is O=C(C1NC2=C(C=CC=C2)C1)OCC, Molecular C11H13NO2Journal, Journal of Chemical and Pharmaceutical Research called Synthesis and biological activity of alkyl-2-[5-(hydroxy-methyl)-5-nitro-2-oxo-1,3,2λ5-dioxaphosphinan-2-yl] amino acid esters, Author is Dadapeer, E.; Naidu, K. Reddi Mohan; Ramesh, M.; Raju, C. Naga; Devamma, M. Nagalakshmi, the main research direction is alkyl hydroxymethylnitrooxodioxaphosphinanyl amino acid ester preparation antibacterial antifungal activity.Related Products of 50501-07-0.

Synthesis of a series of new alkyl-2-[5-(hydroxymethyl)-5-nitro-2-oxo-1,3,2λ5-dioxaphosphinan-2-yl] amino acid esters was accomplished through a two-step process. The key step in the synthesis involves preparation of a dichloride intermediate, with different amino acid esters and with a few substituted phenols by reacting POCl3 in presence of Et3N in THF at 0-15°C. In the second step the intermediate in situ is treated with tris(hydroxymethyl)nitromethane (2-hydroxymethyl-2-nitro-1,3-propanediol) in the presence of Et3N at 40-45°C to form final products. The structures of final products were established by elemental anal., IR, 1H, 13C and 31P NMR and mass spectral data. The antimicrobial activity of these compounds was evaluated and they exhibited moderate antifungal and antibacterial activities.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Convenient synthesis of dioxopiperazines via aminolysis of α-(pyruvylamino) esters》. Authors are Marshall, J. A.; Schlaf, T. F.; Csernansky, J. G..The article about the compound:Ethyl indoline-2-carboxylatecas:50501-07-0,SMILESS:O=C(C1NC2=C(C=CC=C2)C1)OCC).SDS of cas: 50501-07-0. Through the article, more information about this compound (cas:50501-07-0) is conveyed.

Dioxopiperazines I and II were prepared from indoline III by cyclizing with MeNH2 to give dioxopiperazine IV, which was dehydrated to methylene compound V. V added AcSH to give I and II. Analogous reactions starting with pyrrole VI gave dioxopiperazine VII.

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