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Treatment of trans-epoxides 3 with Co2(CO)8 gave the corresponding cobalt complexes, which were subsequently exposed to a catalytic amount of BF3·OEt2 at -78C to provide exclusively cis-2-ethynyl-3- hydroxytetrahydropyran derivatives via endo mode cyclization pathway. cis- Congeners, cis-3 afforded the corresponding trans tetrahydropyran derivatives exclusively. This novel cyclization has been found to proceed with retention of configuration at the propynyl stereogenic center. Requirement for stereoselectivity in cyclization was discussed.

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Tetrahydropyran – Wikipedia,
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The transformation of simple hydrocarbons into more complex and valuable products has revolutionised modern synthetic chemistry. This type of reactivity has quickly become one of the cornerstones of modern catalysis . 51673-83-7, Name is Tetrahydro-2H-pyran-2-carboxylic acid, molecular formula is C6H10O3. In a Patent,once mentioned of 51673-83-7, Application of 51673-83-7

beta-Lactam antibiotics of formula (I) or a salt thereof, wherein R1 is hydrogen, methoxy or formamido; R2 is an acyl group; CO2 R3 is a carboxy group or a carboxylate anion, or R3 is a readily removable carboxy protecting group; R4 represents up to four substituents; X is S, SO, SO2, O or CH2 ; m is 1 or 2; and n is 0, useful in the treatment of bacterial infections. STR1

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Chemistry is a science major with cience and engineering. The main research directions are chemical synthesis, new energy materials, preparation and modification of special coatings, and research on the structure and performance of functional materials51673-83-7, Name is Tetrahydro-2H-pyran-2-carboxylic acid, molecular formula is C6H10O3. In a Patent,once mentioned of 51673-83-7, Quality Control of: Tetrahydro-2H-pyran-2-carboxylic acid

Described are antihypertensive agents selected from the class consisting of 2[4(tetrahydro-2-furoyl)-piperazino]-4-amino-6,7-dimethoxyquinazoline and 2-[4(tetrahydropyran-2-carbonyl)-piperazinyl]-4-amino-6,7-dimethoxyquinazoline, and pharmaceutically acceptable acid addition salts thereof. The compounds are highly water soluble and can be administered in time release form as well as parenterally, including intravenously.

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Reference:
Tetrahydropyran – Wikipedia,
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Chemistry is a science major with cience and engineering. The main research directions are chemical synthesis, new energy materials, preparation and modification of special coatings, and research on the structure and performance of functional materials51673-83-7, Name is Tetrahydro-2H-pyran-2-carboxylic acid, molecular formula is C6H10O3. In a Article,once mentioned of 51673-83-7, COA of Formula: C6H10O3

We describe a novel photoredox hetero-coupling reaction of two C (sp3) radicals from aliphatic acids or BF3K salts. The kinetic differences in radical persistence provide cross-selectivity, using an organic photoredox catalyst and an oxidant with visible light. This method exhibits broad scope, including several examples constructing sterically hindered C(sp3)-C(sp3) bonds.

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Tetrahydropyran – Wikipedia,
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Chemistry involves the study of all things chemical – chemical processes, chemical compositions and chemical manipulation – in order to better understand the way in which materials are structured, how they change and how they react in certain situations.51673-83-7, Name is Tetrahydro-2H-pyran-2-carboxylic acid, molecular formula is C6H10O3. In a Article,once mentioned of 51673-83-7, Formula: C6H10O3

Alkynes are used as building blocks in synthetic and medicinal chemistry, chemical biology, and materials science. Therefore, efficient methods for their synthesis are the subject of intensive research. Herein, we report the direct synthesis of alkynes from readily available carboxylic acids at room temperature under visible-light irradiation. The combination of an iridium photocatalyst with ethynylbenziodoxolone (EBX) reagents allowed the decarboxylative alkynylation of carboxylic acids in good yields under mild conditions. The method could be applied to silyl-, aryl-, and alkyl- substituted alkynes. It was particularly successful in the case of alpha-amino and alpha-oxo acids derived from biomass.

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Compounds of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. I

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Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps. 51673-83-7, Name is Tetrahydro-2H-pyran-2-carboxylic acid, molecular formula is C6H10O3. In a Article,once mentioned of 51673-83-7, COA of Formula: C6H10O3

Saturated heterocycles, such as THFs, pyrrolidines, piperidines and THPs, are essential components of many biologically active compounds. Examples of C-H functionalization on these important ring systems remain scarce, especially at unactivated positions. Here we report the development of conditions for the palladium-catalyzed stereoselective C(sp3)-H arylation at unactivated 3-positions of 5- and 6-membered N- and O-heterocycles with aminoquinoline directing groups. Subtle differences in substrate structures altered their reactivity significantly; and different conditions were required to achieve high yields in each case. Successful conditions were developed using a short empirical optimization approach to cover reaction space with a limited set of variables. Excellent cis-selectivity was achieved in all cases, except for the THP substrate where minor trans-products were formed through a different palladacyclic intermediate. Here, differences in reactivity and selectivity with other directing groups were examined.

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Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. 51673-83-7, Name is Tetrahydro-2H-pyran-2-carboxylic acid, molecular formula is C6H10O3. In a Article,once mentioned of 51673-83-7, COA of Formula: C6H10O3

Alkynes and nitriles are important functional groups that serve as versatile building blocks in organic synthesis and find applications in material and medicinal sciences. A convenient and straightforward access to both classes of compounds under mild conditions is, therefore, highly desirable. Herein, we disclose the decarb-oxylative alkynylation and cyanation of broadly available carboxylic acids using photoredox catalysis and hyper-valent iodine reagents. Choices of both catalysts and reagents were crucial. Computational and experimental studies revealed two different possible mechanisms that are dictated by the oxidation potential of the reagents: radical for alkynylation, ionic for cyanation.

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Decarboxylative cross-coupling of alkyl carboxylic acids with vinyl halides has been accomplished through the synergistic merger of photoredox and nickel catalysis. This new methodology has been successfully applied to a variety of alpha-oxy and alpha-amino acids, as well as simple hydrocarbon-substituted acids. Diverse vinyl iodides and bromides give rise to vinylation products in high efficiency under mild, operationally simple reaction conditions.

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The present invention provides imidazopyrazinones as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

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