Tian, Yiqiang et al. published their research in RSC Advances in 2021 | CAS: 5337-03-1

Tetrahydropyran-4-yl-carboxylic acid (cas: 5337-03-1) belongs to tetrahydropyran derivatives. Tetrahydropyrans and furans principally constitute as a central motif in diverse medicinally privileged molecules. The Prins reaction of homoallylic alcohols with aldehydes afforded an alternative method for the preparation of tetrahydropyrans.Formula: C6H10O3

A facile method for Rh-catalyzed decarbonylative ortho-C-H alkylation of (hetero)arenes with alkyl carboxylic acids was written by Tian, Yiqiang;Liu, Xiaojie;He, Bangyue;Ren, Yuxi;Su, Weiping. And the article was included in RSC Advances in 2021.Formula: C6H10O3 This article mentions the following:

A facile and effective method for Rh-catalyzed direct ortho-alkylation of C-H bonds in (hetero)arenes I (R = 2-methylphenyl, naphthalen-1-yl, thiophen-2-yl, etc.) with com. available carboxylic acids R1COOH (R1 = Et, cyclopentyl, 2-(4-bromophenyl)ethyl, etc.) has been developed. This strategy was initiated by in situ conversion of carboxylic acids to anhydrides which, without isolation, underwent Rh-catalyzed direct decarbonylative cross-coupling of aryl carboxamides containing 8-aminoquinoline I (R = 2,6-diethylphenyl, 2-cyclopentyl-6-methylphenyl, 2-methyl-6-phenylphenyl, etc.). The reaction proceeds with high regioselectivity and exhibits a broad substrate scope as well as functional group tolerance. In the experiment, the researchers used many compounds, for example, Tetrahydropyran-4-yl-carboxylic acid (cas: 5337-03-1Formula: C6H10O3).

Tetrahydropyran-4-yl-carboxylic acid (cas: 5337-03-1) belongs to tetrahydropyran derivatives. Tetrahydropyrans and furans principally constitute as a central motif in diverse medicinally privileged molecules. The Prins reaction of homoallylic alcohols with aldehydes afforded an alternative method for the preparation of tetrahydropyrans.Formula: C6H10O3

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Wang, Jiang et al. published their research in Angewandte Chemie, International Edition in 2020 | CAS: 5337-03-1

Tetrahydropyran-4-yl-carboxylic acid (cas: 5337-03-1) belongs to tetrahydropyran derivatives. Dihydropyrans and tetrahydropyrans are examples of cyclic ethers widespread in nature. One classic procedure for the organic synthesis of tetrahydropyran is by hydrogenation of the 3,4-isomer of dihydropyran with Raney nickel.Recommanded Product: Tetrahydropyran-4-yl-carboxylic acid

Nickel-Catalyzed Synthesis of Dialkyl Ketones from the Coupling of N-Alkyl Pyridinium Salts with Activated Carboxylic Acids was written by Wang, Jiang;Hoerrner, Megan E.;Watson, Mary P.;Weix, Daniel J.. And the article was included in Angewandte Chemie, International Edition in 2020.Recommanded Product: Tetrahydropyran-4-yl-carboxylic acid This article mentions the following:

While ketones are among the most versatile functional groups, their synthesis remains reliant upon reactive and low-abundance starting materials. In contrast, amide formation is the most-used bond-construction method in medicinal chem. because the chem. is reliable and draws upon large and diverse substrate pools. A new method for the synthesis of ketones is presented here that draws from the same substrates used for amide bond synthesis: amines and carboxylic acids. A nickel terpyridine catalyst couples N-alkyl pyridinium salts with in situ formed carboxylic acid fluorides or 2-pyridyl esters under reducing conditions (Mn metal). The reaction has a broad scope, as demonstrated by the synthesis of 35 different ketones bearing a wide variety of functional groups with an average yield of 60±16%. This approach is capable of coupling diverse substrates, including pharmaceutical intermediates, to rapidly form complex ketones. In the experiment, the researchers used many compounds, for example, Tetrahydropyran-4-yl-carboxylic acid (cas: 5337-03-1Recommanded Product: Tetrahydropyran-4-yl-carboxylic acid).

Tetrahydropyran-4-yl-carboxylic acid (cas: 5337-03-1) belongs to tetrahydropyran derivatives. Dihydropyrans and tetrahydropyrans are examples of cyclic ethers widespread in nature. One classic procedure for the organic synthesis of tetrahydropyran is by hydrogenation of the 3,4-isomer of dihydropyran with Raney nickel.Recommanded Product: Tetrahydropyran-4-yl-carboxylic acid

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Kodo, Taiga et al. published their research in Nature Communications in 2022 | CAS: 5337-03-1

Tetrahydropyran-4-yl-carboxylic acid (cas: 5337-03-1) belongs to tetrahydropyran derivatives. Dihydropyrans and tetrahydropyrans are examples of cyclic ethers widespread in nature. One classic procedure for the organic synthesis of tetrahydropyran is by hydrogenation of the 3,4-isomer of dihydropyran with Raney nickel.COA of Formula: C6H10O3

Organophotoredox-catalyzed semipinacol rearrangement via radical-polar crossover was written by Kodo, Taiga;Nagao, Kazunori;Ohmiya, Hirohisa. And the article was included in Nature Communications in 2022.COA of Formula: C6H10O3 This article mentions the following:

The organophotoredox-catalyzed semipinacol rearrangement via radical-polar crossover (RPC) was reported. A phenothiazine-based organophotoredox catalyst facilitates the generation of an α-hydroxy non-benzylic alkyl radical followed by oxidation to the corresponding carbocation, which was exploited to undergo the semipinacol rearrangement. As a result, the photochem. approach enables decarboxylative semipinacol rearrangement of β-hydroxycarboxylic acid derivatives and alkylative semipinacol type rearrangement of allyl alcs. with carbon electrophiles, producing α-quaternary or α-tertiary carbonyls bearing sp3-rich scaffolds. In the experiment, the researchers used many compounds, for example, Tetrahydropyran-4-yl-carboxylic acid (cas: 5337-03-1COA of Formula: C6H10O3).

Tetrahydropyran-4-yl-carboxylic acid (cas: 5337-03-1) belongs to tetrahydropyran derivatives. Dihydropyrans and tetrahydropyrans are examples of cyclic ethers widespread in nature. One classic procedure for the organic synthesis of tetrahydropyran is by hydrogenation of the 3,4-isomer of dihydropyran with Raney nickel.COA of Formula: C6H10O3

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Nguyen, Viet D. et al. published their research in Angewandte Chemie, International Edition in 2022 | CAS: 5337-03-1

Tetrahydropyran-4-yl-carboxylic acid (cas: 5337-03-1) belongs to tetrahydropyran derivatives. In organic synthesis, the 2-tetrahydropyranyl group is used as a protecting group for alcohols. Pyran derivatives such as pyran flavonoids are biologically important. Monosaccharides containing six-membered rings are called pyranose.Product Details of 5337-03-1

Decarboxylative Sulfinylation Enables a Direct, Metal-Free Access to Sulfoxides from Carboxylic Acids was written by Nguyen, Viet D.;Haug, Graham C.;Greco, Samuel G.;Trevino, Ramon;Karki, Guna B.;Arman, Hadi D.;Larionov, Oleg V.. And the article was included in Angewandte Chemie, International Edition in 2022.Product Details of 5337-03-1 This article mentions the following:

A data-guided development of direct decarboxylative sulfinylation that enables the previously inaccessible functional group interconversion of carboxylic acids to sulfoxides in a reaction with sulfinates was reported. Given the broad availability of carboxylic acids and the growing synthetic potential of sulfinates, the direct decarboxylative sulfinylation was poised to improve the structural diversity of synthetically accessible sulfoxides. The reaction was facilitated by a kinetically favored sulfoxide formation from the intermediate sulfinyl sulfones, despite the strong thermodn. preference for the sulfone formation, unveiling the previously unknown and chemoselective radicalophilic sulfinyl sulfone reactivity. In the experiment, the researchers used many compounds, for example, Tetrahydropyran-4-yl-carboxylic acid (cas: 5337-03-1Product Details of 5337-03-1).

Tetrahydropyran-4-yl-carboxylic acid (cas: 5337-03-1) belongs to tetrahydropyran derivatives. In organic synthesis, the 2-tetrahydropyranyl group is used as a protecting group for alcohols. Pyran derivatives such as pyran flavonoids are biologically important. Monosaccharides containing six-membered rings are called pyranose.Product Details of 5337-03-1

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Wang, Peng-Zi et al. published their research in Angewandte Chemie, International Edition in 2021 | CAS: 5337-03-1

Tetrahydropyran-4-yl-carboxylic acid (cas: 5337-03-1) belongs to tetrahydropyran derivatives. Dihydropyrans and tetrahydropyrans are examples of cyclic ethers widespread in nature. The most notable anticancer agent, bryostatin, and eribulin are marine macrolides having intriguing tetrahydropyran and furan motif. Product Details of 5337-03-1

Photoinduced Copper-Catalyzed Asymmetric Three-Component Coupling of 1,3-Dienes: An Alternative to Kharasch-Sosnovsky Reaction was written by Wang, Peng-Zi;Wu, Xue;Cheng, Ying;Jiang, Min;Xiao, Wen-Jing;Chen, Jia-Rong. And the article was included in Angewandte Chemie, International Edition in 2021.Product Details of 5337-03-1 This article mentions the following:

Herein, an alternative to the asym. Kharasch-Sosnovsky reaction that utilized a chiral copper catalyst and purple-LED irradiation to enable the three-component coupling of 1,3-dienes RCH=CHC(R1)=CHR2 (R = H, Me; R1 = H, Me; R2 = Ph, 2-phenylethyl, furan-3-yl, etc.), oxime esters I (R3 = H, Me; R4 = H; R3R4 = -CH=CH-CH=CH-; R5 = H; R4R5 = -CH2N(Boc)CH2-, -(CH2)2N(Boc)(CH2)2-), and carboxylic acids R6C(O)OH (R5 = t-Bu, Ph, 2H-1,3-benzodioxol-5-yl, etc.) is reported. This protocol features mild conditions, remarkable scope and functional group tolerance as evidenced by >80 examples and utility in the late-stage modification of pharmaceuticals and natural products. Detailed mechanistic studies provide evidences for the radical-based reaction pathway. In the experiment, the researchers used many compounds, for example, Tetrahydropyran-4-yl-carboxylic acid (cas: 5337-03-1Product Details of 5337-03-1).

Tetrahydropyran-4-yl-carboxylic acid (cas: 5337-03-1) belongs to tetrahydropyran derivatives. Dihydropyrans and tetrahydropyrans are examples of cyclic ethers widespread in nature. The most notable anticancer agent, bryostatin, and eribulin are marine macrolides having intriguing tetrahydropyran and furan motif. Product Details of 5337-03-1

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics