Category: 53911-68-5

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 53911-68-5, Name is 4-(4-Chlorophenyl)dihydro-2H-pyran-2,6(3H)-dione, molecular formula is C11H9ClO3. In a Article£¬once mentioned of 53911-68-5, Formula: C11H9ClO3

One-pot enzymatic desymmetrization and Ugi MCR

A new approach to the synthesis of chiral peptidomimetics is reported. It combines an enzymatic desymmetrization of 3-phenylglutaric anhydrides with a subsequent Ugi multi-component reaction in a one-pot, two-step procedure. NMR and CD spectroscopy was used to assign the configurations of obtained products. Our synthetic method is very efficient and it can easily be extended to other types of multi-component reactions and can be used for the preparation of chiral peptidomimetic libraries.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.Formula: C11H9ClO3, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 53911-68-5, in my other articles.

Reference£º
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.53911-68-5, Name is 4-(4-Chlorophenyl)dihydro-2H-pyran-2,6(3H)-dione, molecular formula is C11H9ClO3. In a Article£¬once mentioned of 53911-68-5, Application In Synthesis of 4-(4-Chlorophenyl)dihydro-2H-pyran-2,6(3H)-dione

Studies on enzymatic synthesis of chiral non-racemic 3-arylglutaric acid monoesters

The enantioselective enzymatic desymmetrization (EED) of various 3-arylglutaric anhydrides 1 with alcohols in organic media has been studied. The effect of the solvent on the stereochemical outcome of the reaction was investigated in detail. The amount of biocatalyst was optimized, and the possibility of its re-use was tested. The first example of the EED of 3-substituted glutaric anhydrides with esters as nucleophiles is reported.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Application In Synthesis of 4-(4-Chlorophenyl)dihydro-2H-pyran-2,6(3H)-dione, you can also check out more blogs about53911-68-5

Reference£º
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

In an article, published in an article, once mentioned the application of 53911-68-5, Name is 4-(4-Chlorophenyl)dihydro-2H-pyran-2,6(3H)-dione,molecular formula is C11H9ClO3, is a conventional compound. this article was the specific content is as follows.Product Details of 53911-68-5

Development of Bifunctional Thiourea Organocatalysts Derived from a Chloramphenicol Base Scaffold and their Use in the Enantioselective Alcoholysis of meso Cyclic Anhydrides

The synthesis of new chloramphenicol-base-derived thiourea organocatalysts, (1S,2R)-12 a?f and (1R,2R)-15 a?c, and their use in the enantioselective alcoholysis of meso-anhydrides are described. In particular, hemiesters afforded excellent enantioselectivities if low loadings of (1S,2R)-12 a?f were used. Almost no enantioselectivities were achieved with the use of (1R,2R)-15 a?c. This technique was used to synthesize (R)-(?)-baclofen.

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Reference£º
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn¡¯t involve a screen. 53911-68-5, 53911-68-5, C11H9ClO3. A document type is Article, introducing its new discovery.

One catalyst for both enantiomers: Uncovering the inversion of enantioselectivity in cinchona-mediated desymmetrization of glutaric meso-anhydrides

A puzzling inversion of enantioselectivity dependent on catalyst loading was observed during the quinine-mediated desymmetrization of glutaric meso-anhydrides. This study presents the improvement of the catalytic path by the inclusion of carboxylic acid additives up to synthetically useful levels. The novel protocol utilizing 0.1 equiv of alkaloid and xanthene-9-carboxylic acid at room temperature (rt) was found comparable to the protocol requiring 1.1 equiv of alkaloid at -30 C. Thus, by altering the protocol the same catalyst produces the opposite enantiomer. This occurrence was rationalized by an extensive computational study of the interactions governing the molecular complexes formed by quinine, methanol, 3-methylglutaric anhydride, and the acetic acid. It was found that in a quinine catalyzed reaction the alcohol and the anhydride were directly hydrogen bonded to the catalyst. On the other hand, in the reaction with additive the acid intercalates between the alcohol and quinine. Due to this insertion the alcohol approaches the anhydride from the opposite face, in agreement with the observed inversion of enantioselectivity

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.53911-68-5,4-(4-Chlorophenyl)dihydro-2H-pyran-2,6(3H)-dione,as a common compound, the synthetic route is as follows.,53911-68-5

The solution of commercial 4,5-dichloro-1,2-phenylenediamine (0.36 g) and triethyl amine (0.32 ml) in 1,4-dioxane (1.5 ml) was added to a solution of 3-(4-chlorophenyl)glutaric anhydride (0.45 g) in 1,4-dioxane (1 ml) with ice cooling. The resulting mixture was stirred at rt for 0.5 h and at 40 C. for 0.5 h. Again under ice cooling 1M HCl (3 ml) was added dropwise. A gummy precipitate is formed. After 0.5 h of cooling the aqueous layer is removed by decantation and the residue is dissolved in methanol. The dark solution is decolourised with activated carbon, filtered, and the filtrate concentrated in vacuo. The amorphous solid is redissolved in ethanol (6 ml) and conc. HCl (2 ml) and stirred at reflux for 16 h. After cooling to rt the pH is adjusted to 8 by addition of first NaOH solution, then sat. sodium bicarbonate solution. The aqueous layer is extracted with dichloromethane (40 ml) and the organic layer is washed with sat. sodium chloride solution and dried (sodium sulfate). After concentration the crude (0.46 g) is purified by flash chromatography ((dichloromethane /2% methanol /1% triethyl amine) on silica gel to afford ethyl 4-(5,6-dichloro-2-benzimidazolyl)-3-(4-chlorophenyl)butanoate (0.33 g) as yellowish, amorphous solid

As the paragraph descriping shows that 53911-68-5 is playing an increasingly important role.

Reference£º
Patent; UNIVERSITAET DES SAARLANDES; US2012/46307; (2012); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

53911-68-5,53911-68-5, 4-(4-Chlorophenyl)dihydro-2H-pyran-2,6(3H)-dione is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The solution of commercial 4,5-dichloro-l,2-phenylenediamine (0.36 g) and triethyl amine (0.32 ml) in 1,4-dioxane (1.5 ml) was added to a solution of 3-(4- chlorophenyl)glutaric anhydride (0.45 g) in 1,4-dioxane (1 ml) with ice cooling. The resulting mixture was stirred at rt for 0.5 h and at 400C for 0.5 h. Again under ice cooling IM HCI (3 ml) was added dropwise. A gummy precipitate is formed. After 0.5 h of cooling the aqueous layer is removed by decantation and the residue is dissolved in methanol. The dark solution is decolourised with activated carbon, filtered, and the filtrate concentrated in vacuo. The amorphous solid is redissolved in ethanol (6 ml) and cone. HCI (2 ml) and stirred at reflux for 16 h. After cooling to rt the pH is adjusted to 8 by addition of first NaOH solution, then sat. sodium bicarbonate solution. The aqueous layer is extracted with dichloromethane (40 ml) and the organic layer is washed with sat. sodium chloride solution and dried (sodium sulfate). After concentration the crude (0.46 g) is purified by flash chromatography ((dichloromethane/2% methanol/1% triethyl amine) on silica gel to afford ethyl 4-(5,6-dichloro-2-benzimidazolyl)-3-(4-chlorophenyl)butanoate (0.33 g) as yellowish, amorphous solid.

53911-68-5 4-(4-Chlorophenyl)dihydro-2H-pyran-2,6(3H)-dione 104639, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; UNIVERSITAET DES SAARLANDES; ENGEL, Matthias; FROeHNER, Wolfgang; STROBA, Adriane; BIONDI, Ricardo M.; WO2010/43711; (2010); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

53911-68-5, 4-(4-Chlorophenyl)dihydro-2H-pyran-2,6(3H)-dione is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

53911-68-5, Prepared by dissolving an equimolar mixture of 3-(4-chlorophenyl)glutaric anhydride and commercial 5-chloro-2-hydroxyaniline in boiling dichloromethane. Upon cooling to rt product precipitates and yields after isolation 87% of /V-(2-hydroxy-5- chlorophenyl)-3-(4-chlorophenyl)glutaramic acid as colourless crystals.

The synthetic route of 53911-68-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; UNIVERSITAET DES SAARLANDES; ENGEL, Matthias; FROeHNER, Wolfgang; STROBA, Adriane; BIONDI, Ricardo M.; WO2010/43711; (2010); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

53911-68-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.53911-68-5,4-(4-Chlorophenyl)dihydro-2H-pyran-2,6(3H)-dione,as a common compound, the synthetic route is as follows.

3-(4-Chlorophenyl)glutaric anhydride (0.45 g) was added with stirring at rt to the solution of commercial 4-tbutyl-1,2-phenylenediamine (0.33 g) in dichloromethane (3 ml). After 1 h at rt the precipitate is collected by suction filtration, washed with dichloromethane, and dried in vacuo to give a mixture of regioisomeric amides (0.63 g) as light grey solid. The solid was suspended in 1,4-dioxane (2 ml) and 4M HCl in 1,4-dioxane (3 ml) was added. The solution is heated to reflux for 1.5 h. From the solution all volatiles are removed at the water aspirator and the residue is recrystallised from acetone /ethyl acetate to give 4-(5-tbutyl-2-benzimidazolyl)-3-(4-chlorophenyl)butanoic acid HCl (0.45 g) as light grey solid.1H-NMR (500 MHz, DMSO-d6)): delta (ppm)=1.32 (s, 9H), 2.71 (dd, J=16.2, 8.6 Hz, 1H), 2.81 (dd, J=16.2, 6.1 Hz, 1H), 3.47 (dd, J=15.0, 9.4 Hz, 1H), 3.56 (dd, J=15.0, 6.7 Hz, 1H), 3.89 (m, 1H), 7.30 (d, J=8.5 Hz, 2H), 7.38 (d, J=8.5 Hz, 2H), 7.56 (dd, J=8.7, 1.7 Hz, 1H), 7.59 (d, J=1.0 Hz, 1H), 7.63 (d, J=8.7 Hz, 1H).13C-NMR and DEPT (125 MHz, DMSO-d6): delta (ppm)=31.11 (3CH3), 32.31 (CH2), 34.74 (C), 39.15 (CH), 109.32 (CH), 113.12 (CH), 123.56 (CH), 128.35 (2CH), 128.51 (C), 129.18 (2CH), 130.64 (C), 131.43 (C), 140.67 (C), 148.65 (C), 151.53 (C), 172.09 (CO). One carbon signal missing.

The synthetic route of 53911-68-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; UNIVERSITAET DES SAARLANDES; US2012/46307; (2012); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

53911-68-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.53911-68-5,4-(4-Chlorophenyl)dihydro-2H-pyran-2,6(3H)-dione,as a common compound, the synthetic route is as follows.

General procedure: An alcohol (5 mmol) was added dropwise at room temperature under nitrogen to astirred solution of an anhydride 8 (0.5 mmol) and 7i (36.1 mg, 0.05 mmol) in MTBE(20 mL). The reaction was monitored by using thin-layer chromatography. Onceanhydride consumption was complete, the solvent was evaporated under reducedpressure and the residue was dissolved in CH2Cl2 (10 mL). The solution was washedwith saturated Na2CO3 (2 ¡Á 5 mL) and the combined aqueous phase were acidifiedwith excess 2 N HCl, followed by extraction with EtOAc (3 ¡Á 10 mL). The combinedorganic phases were dried over Na2SO4 and concentrated to afford the correspondingmonoester, without further purification by flash chromatography

53911-68-5 4-(4-Chlorophenyl)dihydro-2H-pyran-2,6(3H)-dione 104639, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Article; Xu, Lingjun; Han, Shuwen; Yan, Linjie; Wang, Haifeng; Peng, Haihui; Chen, Fener; Beilstein Journal of Organic Chemistry; vol. 14; (2018); p. 309 – 317;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics