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Treatment of 3,4-dihydro-2H-pyran 1 with various alcohols 2 – 10 furnished the tetrahydropyranyl ethers 11 – 19 in the presence of 5M lithium perchlorate in diethyl ether (5M LPDE), which is essentially a neutral medium.

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

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The synthesis of Costa-type B12 models 1 with a carbon bridge between the equatorial ligand and cobalt has been accomplished by condensation of butanedione monoxime and 2-(omega-functionalized)alkyl-1,3-diaminopropanes 8 followed by complexation with Co(II), introduction of a leaving group and intramolecular alkylation via Co(I) intermediates. The solution structure of intramolecularly alkylated Costa complexes with a bridge of two (1a) or of three (1b) methylene groups was investigated by NMR spectroscopy and compared with that of propyl(iodo) Costa complex 13.

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

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Several derivatives of 4-phenoxyphenoxy-ethyl and 4-phenoxyphenylethyl bearing carbonate and thiolcarbonate as functional groups were synthesized.The products were tested for their respective juvenile hormone activity for Triatoma infestans.None of them showed an activity comparable to that of Fenoxycarb which was used as the standard control.The synthetic procedures and the biological results are discussed.Keywords: Juvenile Hormone Analogues, Activity, Synthesis

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

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A series of acyl silanes including aliphatic-, aromatic-, and bis-acyl silanes, as well as the acyl silanes bearing other substituents such as a bromine atom and alkenyl, succinimide, and carbonyl groups, were prepared, and their reactions with samarium diiodide or tributylstannane were studied. The reactions of acyl silanes occurred in various manners such as reductions, reductive alkylations, intramolecular radical cyclizations, pinacol couplings, aldol reactions, and Tishchenko reactions, depending on the nature of substrates and reaction conditions. Acyl silanes were generally reduced to give the corresponding alpha-silyl alcohols without transfer of silyl groups. Intramolecular radical cyclizations of 5-hexenoyl silanes and 1-silyl-1,5-pentanedione were realized to give alpha-silyl cyclopentanols and 1,2-cyclopentanediol derivatives, respectively. On treatment with samarium diiodide in tetrahydrofuran, 1-(trimethylsilyl)-1,6-hexanedione underwent a pinacol coupling reaction in the presence of t-BuOH, whereas it underwent a Tishchenko reaction in the presence of MeOH. The Tishchenko reaction of 1-silyl-1,5-pentanedione gave a delta-silyl-delta-lactone. On treating with samarium diiodide, 1-(trimethylsilyl)-1,5-hexanedione and 1,5-bis(trimethylsilyl)-1,6-hexanedione, underwent, respectively, intramolecular aldol reactions.

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Reference£º
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

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New lipophilic neutral ligands which combine crown ether and podand characteristics with structural features of surfactants (cf. formulas 1-12, 16-26) were synthesized.Their complexation behaviour was studied, their solid-to-liquid and liquid-to-liquid phase transfer properties as well as their efficiency in ion transport across a liquid model membrane.Crystalline stoichiometric complexes of the cycles 2a-4a and of 3e with NaSCN, Ba(SCN)2, and BaI2 can be isolated.Among the noncyclic representatives a crystalline complex is obtained only from 11 with BaI2.The ligand 8d behaves in aqueous solution as a typical surfactant showing micelle formation and cloud point.

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

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Nitrogen-containing heterocyclic derivatives and their angiogenesis diseases of the retina in the application (by machine translation)

The invention discloses a nitrogen-containing heterocyclic derivatives and their angiogenesis diseases of the retina in the application, the nitrogen-containing heterocyclic derivatives is the formula Wherein R1 , R2 , R3 , R4 Independently selected from – H or – CN. In the 5 mug/mL under the same concentration, the implementation of the example two, implementation […] HRCEC […] and implementation of growth inhibition rate of the superior to the monoclonal antibody medicine Avastin. To the intravitreal injection after administration, the compounds of the invention can reduce the pathological neovascularization, illustrate the invention nitrogen-containing heterocyclic […] I or the salts thereof can be used for the treatment of retinal angiogenesis related diseases in-depth research and development, the diseases such as retinal vein occlusion, shelter for diabetic retinopathy, retinal new blood vessel membrane, neovascular glaucoma, premature retinopathy, such as proliferative vitreoretinopathy. (by machine translation)

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

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SUBSTITUTED PHENYL IMIDAZOLYL PIPERIDYL COMPOUNDS AS P70S6K1 INHIBITORS

The present invention relates to novel substituted phenyl imidazolyl piperidyl compounds that inhibit activity ofP70S6KI, pharmaceutical compositions comprising the compounds, and methods of using the compounds to treat physiological disorders, such as dyslipidemia, preferably hyperlipidemia, more preferably hypercholesterolemia and/ or hypertriglyceridemia.

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

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Polytopic Cation Receptors. 2. Synthesis and Selective Complex Formation of Spiro-Linked “Multiloop Crown Compounds”

A new type of crown compound (1-10) featuring a spiro-linked assembly of two to four individual macrorings differing in ring size, rigidity, and donor characteristics is synthesized.Syntheses were achieved by means of high-dilution techniques and blocking/deblocking procedures beginning with pentaerythritol as the basic building block.The ability of the new ligands (“multiloop crown compounds”) to selectively form crystalline polyhomonuclear/heteronuclear complexes is studied.It is found that the symmetrically looped molecules (1a-c, 4a, 6, 7d) can incorporate two orthree identical metal cations well matched in their diameter (Li+, Na+, K+, Ca2+, Ba2+).Cations which are too large to fit into the crown rings of 1a-c complex in a sandwich-like manner; those which are too small effect a high hydration in their complexes.Asymmetrical 1d and 9 allow the common uptake of different metal ions, e.g., a combination of Li+ and Ba2+ or of 2K+ and Co2+.The specific occupation of the different subrings is discussed.Ligand 1b is shown to discriminate Ca2+ from Na+; 1c and 6 preferentially complex Ba2+ from a Ba2+/K+ mixture.Thus, the new ligands act as manifold selective cation receptors, corresponding to the specification of their binding compartments.

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

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Synthesis and cation complexation properties of new macrolides

The cis-2-alkyl-3-oxy-tetrahydropyran unit as a novel structure for the design and synthesis of a new type of ionophores with C2-symmetry is reported. The synthesis of seven different macrolides and a crown ether and their cation complexation properties were investigated. The X-ray crystal structure of some of the receptors provides valuable information on the preferred conformation of tetrahydropyrans in the solid state that can be related to the cation complexation properties in solution. The kinetic template effect has been proved to be a useful tool to improve the yield and selectivity in the synthesis of macrodiolide 3.

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

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Contrast media for infarction and necrosis imaging

The invention relates to new compounds that are suitable as contrast media especially for infarction and necrosis imaging, process for their production and pharmaceutical agents that contain these compounds.

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics