Category: 603130-12-7

HPLC of Formula: 603130-12-7. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: tert-Butyl ((3R,6S)-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)carbamate, is researched, Molecular C11H21NO4, CAS is 603130-12-7, about Design, Synthesis, and Characterization of Novel Tetrahydropyran-Based Bacterial Topoisomerase Inhibitors with Potent Anti-Gram-Positive Activity. Author is Surivet, Jean-Philippe; Zumbrunn, Cornelia; Rueedi, Georg; Hubschwerlen, Christian; Bur, Daniel; Bruyere, Thierry; Locher, Hans; Ritz, Daniel; Keck, Wolfgang; Seiler, Peter; Kohl, Christopher; Gauvin, Jean-Christophe; Mirre, Azely; Kaegi, Verena; Dos Santos, Marina; Gaertner, Mika; Delers, Jonathan; Enderlin-Paput, Michel; Boehme, Maria.

There is an urgent need for new antibacterial drugs that are effective against infections caused by multidrug-resistant pathogens. Novel nonfluoroquinolone inhibitors of bacterial type II topoisomerases (DNA gyrase and topoisomerase IV) have the potential to become such drugs because they display potent antibacterial activity and exhibit no target-mediated cross-resistance with fluoroquinolones. Bacterial topoisomerase inhibitors that are built on a tetrahydropyran ring linked to a bicyclic aromatic moiety through a syn-diol linker show potent anti-Gram-pos. activity, covering isolates with clin. relevant resistance phenotypes. For instance, analog I was found to be a dual DNA gyrase-topoisomerase IV inhibitor, with broad antibacterial activity and low propensity for spontaneous resistance development, but suffered from high hERG K+ channel block. On the other hand, analog II displayed lower hERG K+ channel block while retaining potent in vitro antibacterial activity and acceptable frequency for resistance development. Furthermore, analog II showed moderate clearance in rat and promising in vivo efficacy against Staphylococcus aureus in a murine infection model.

The article 《Design, Synthesis, and Characterization of Novel Tetrahydropyran-Based Bacterial Topoisomerase Inhibitors with Potent Anti-Gram-Positive Activity》 also mentions many details about this compound(603130-12-7)HPLC of Formula: 603130-12-7, you can pay attention to it, because details determine success or failure

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, European Journal of Organic Chemistry called Synthesis of novel tetrahydropyran-based dipeptide isosteres by Overman rearrangement of 2,3-didehydroglycosides, Author is Kriek, Nicole M. A. J.; van der Hout, Elise; Kelly, Paskal; van Meijgaarden, Krista E.; Geluk, Annemieke; Ottenhoff, Tom H. M.; van der Marel, Gijs A.; Overhand, Mark; van Boom, Jacques H.; Valentijn, A. Rob P. M.; Overkleeft, Herman S., which mentions a compound: 603130-12-7, SMILESS is O=C(OC(C)(C)C)N[C@H]1CO[C@H](CO)CC1, Molecular C11H21NO4, HPLC of Formula: 603130-12-7.

Differently functionalized tetrahydropyran-based dipeptide isosteres have been efficiently synthesized from 3,4,6-tri-O-acetyl-D-glucal. Analogs of the hsp65 p2-13 epitope of Mycobacterium tuberculosis and Mycobacterium leprae were prepared by replacement of the Ala-Tyr or Glu-Glu moiety in the native dodecapeptide with the prepared dipeptide isosteres.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Synthetic Route of C11H21NO4. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: tert-Butyl ((3R,6S)-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)carbamate, is researched, Molecular C11H21NO4, CAS is 603130-12-7, about Synthesis of novel tetrahydropyran-based dipeptide isosteres by Overman rearrangement of 2,3-didehydroglycosides. Author is Kriek, Nicole M. A. J.; van der Hout, Elise; Kelly, Paskal; van Meijgaarden, Krista E.; Geluk, Annemieke; Ottenhoff, Tom H. M.; van der Marel, Gijs A.; Overhand, Mark; van Boom, Jacques H.; Valentijn, A. Rob P. M.; Overkleeft, Herman S..

Differently functionalized tetrahydropyran-based dipeptide isosteres have been efficiently synthesized from 3,4,6-tri-O-acetyl-D-glucal. Analogs of the hsp65 p2-13 epitope of Mycobacterium tuberculosis and Mycobacterium leprae were prepared by replacement of the Ala-Tyr or Glu-Glu moiety in the native dodecapeptide with the prepared dipeptide isosteres.

Here is just a brief introduction to this compound(603130-12-7)Synthetic Route of C11H21NO4, more information about the compound(tert-Butyl ((3R,6S)-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)carbamate) is in the article, you can click the link below.

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Surivet, Jean-Philippe; Zumbrunn, Cornelia; Rueedi, Georg; Hubschwerlen, Christian; Bur, Daniel; Bruyere, Thierry; Locher, Hans; Ritz, Daniel; Keck, Wolfgang; Seiler, Peter; Kohl, Christopher; Gauvin, Jean-Christophe; Mirre, Azely; Kaegi, Verena; Dos Santos, Marina; Gaertner, Mika; Delers, Jonathan; Enderlin-Paput, Michel; Boehme, Maria published the article 《Design, Synthesis, and Characterization of Novel Tetrahydropyran-Based Bacterial Topoisomerase Inhibitors with Potent Anti-Gram-Positive Activity》. Keywords: pyran tetrahydro Gram pos bacterial topoisomerase inhibitor; DNA gyrase topoisomerase inhibitor tetrahydropyran bicyclic aromatic derivative.They researched the compound: tert-Butyl ((3R,6S)-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)carbamate( cas:603130-12-7 ).Computed Properties of C11H21NO4. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:603130-12-7) here.

There is an urgent need for new antibacterial drugs that are effective against infections caused by multidrug-resistant pathogens. Novel nonfluoroquinolone inhibitors of bacterial type II topoisomerases (DNA gyrase and topoisomerase IV) have the potential to become such drugs because they display potent antibacterial activity and exhibit no target-mediated cross-resistance with fluoroquinolones. Bacterial topoisomerase inhibitors that are built on a tetrahydropyran ring linked to a bicyclic aromatic moiety through a syn-diol linker show potent anti-Gram-pos. activity, covering isolates with clin. relevant resistance phenotypes. For instance, analog I was found to be a dual DNA gyrase-topoisomerase IV inhibitor, with broad antibacterial activity and low propensity for spontaneous resistance development, but suffered from high hERG K+ channel block. On the other hand, analog II displayed lower hERG K+ channel block while retaining potent in vitro antibacterial activity and acceptable frequency for resistance development. Furthermore, analog II showed moderate clearance in rat and promising in vivo efficacy against Staphylococcus aureus in a murine infection model.

Compound(603130-12-7)Computed Properties of C11H21NO4 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(tert-Butyl ((3R,6S)-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)carbamate), if you are interested, you can check out my other related articles.

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Design, Synthesis, and Characterization of Novel Tetrahydropyran-Based Bacterial Topoisomerase Inhibitors with Potent Anti-Gram-Positive Activity, published in 2013-09-26, which mentions a compound: 603130-12-7, mainly applied to pyran tetrahydro Gram pos bacterial topoisomerase inhibitor; DNA gyrase topoisomerase inhibitor tetrahydropyran bicyclic aromatic derivative, COA of Formula: C11H21NO4.

There is an urgent need for new antibacterial drugs that are effective against infections caused by multidrug-resistant pathogens. Novel nonfluoroquinolone inhibitors of bacterial type II topoisomerases (DNA gyrase and topoisomerase IV) have the potential to become such drugs because they display potent antibacterial activity and exhibit no target-mediated cross-resistance with fluoroquinolones. Bacterial topoisomerase inhibitors that are built on a tetrahydropyran ring linked to a bicyclic aromatic moiety through a syn-diol linker show potent anti-Gram-pos. activity, covering isolates with clin. relevant resistance phenotypes. For instance, analog I was found to be a dual DNA gyrase-topoisomerase IV inhibitor, with broad antibacterial activity and low propensity for spontaneous resistance development, but suffered from high hERG K+ channel block. On the other hand, analog II displayed lower hERG K+ channel block while retaining potent in vitro antibacterial activity and acceptable frequency for resistance development. Furthermore, analog II showed moderate clearance in rat and promising in vivo efficacy against Staphylococcus aureus in a murine infection model.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 603130-12-7, is researched, Molecular C11H21NO4, about Design, Synthesis, and Characterization of Novel Tetrahydropyran-Based Bacterial Topoisomerase Inhibitors with Potent Anti-Gram-Positive Activity, the main research direction is pyran tetrahydro Gram pos bacterial topoisomerase inhibitor; DNA gyrase topoisomerase inhibitor tetrahydropyran bicyclic aromatic derivative.Recommanded Product: tert-Butyl ((3R,6S)-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)carbamate.

There is an urgent need for new antibacterial drugs that are effective against infections caused by multidrug-resistant pathogens. Novel nonfluoroquinolone inhibitors of bacterial type II topoisomerases (DNA gyrase and topoisomerase IV) have the potential to become such drugs because they display potent antibacterial activity and exhibit no target-mediated cross-resistance with fluoroquinolones. Bacterial topoisomerase inhibitors that are built on a tetrahydropyran ring linked to a bicyclic aromatic moiety through a syn-diol linker show potent anti-Gram-pos. activity, covering isolates with clin. relevant resistance phenotypes. For instance, analog I was found to be a dual DNA gyrase-topoisomerase IV inhibitor, with broad antibacterial activity and low propensity for spontaneous resistance development, but suffered from high hERG K+ channel block. On the other hand, analog II displayed lower hERG K+ channel block while retaining potent in vitro antibacterial activity and acceptable frequency for resistance development. Furthermore, analog II showed moderate clearance in rat and promising in vivo efficacy against Staphylococcus aureus in a murine infection model.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Recommanded Product: tert-Butyl ((3R,6S)-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)carbamate. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: tert-Butyl ((3R,6S)-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)carbamate, is researched, Molecular C11H21NO4, CAS is 603130-12-7, about Synthesis of novel tetrahydropyran-based dipeptide isosteres by Overman rearrangement of 2,3-didehydroglycosides. Author is Kriek, Nicole M. A. J.; van der Hout, Elise; Kelly, Paskal; van Meijgaarden, Krista E.; Geluk, Annemieke; Ottenhoff, Tom H. M.; van der Marel, Gijs A.; Overhand, Mark; van Boom, Jacques H.; Valentijn, A. Rob P. M.; Overkleeft, Herman S..

Differently functionalized tetrahydropyran-based dipeptide isosteres have been efficiently synthesized from 3,4,6-tri-O-acetyl-D-glucal. Analogs of the hsp65 p2-13 epitope of Mycobacterium tuberculosis and Mycobacterium leprae were prepared by replacement of the Ala-Tyr or Glu-Glu moiety in the native dodecapeptide with the prepared dipeptide isosteres.

If you want to learn more about this compound(tert-Butyl ((3R,6S)-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)carbamate)Recommanded Product: tert-Butyl ((3R,6S)-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)carbamate, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(603130-12-7).

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Kriek, Nicole M. A. J.; van der Hout, Elise; Kelly, Paskal; van Meijgaarden, Krista E.; Geluk, Annemieke; Ottenhoff, Tom H. M.; van der Marel, Gijs A.; Overhand, Mark; van Boom, Jacques H.; Valentijn, A. Rob P. M.; Overkleeft, Herman S. researched the compound: tert-Butyl ((3R,6S)-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)carbamate( cas:603130-12-7 ).Synthetic Route of C11H21NO4.They published the article 《Synthesis of novel tetrahydropyran-based dipeptide isosteres by Overman rearrangement of 2,3-didehydroglycosides》 about this compound( cas:603130-12-7 ) in European Journal of Organic Chemistry. Keywords: tetrahydropyran peptide isostere preparation Overman rearrangement dehydroglycoside; epitope Mycobacterium tuberculosis leprae peptide tetrahydropyran isostere preparation. We’ll tell you more about this compound (cas:603130-12-7).

Differently functionalized tetrahydropyran-based dipeptide isosteres have been efficiently synthesized from 3,4,6-tri-O-acetyl-D-glucal. Analogs of the hsp65 p2-13 epitope of Mycobacterium tuberculosis and Mycobacterium leprae were prepared by replacement of the Ala-Tyr or Glu-Glu moiety in the native dodecapeptide with the prepared dipeptide isosteres.

Here is a brief introduction to this compound(603130-12-7)Synthetic Route of C11H21NO4, if you want to know about other compounds related to this compound(603130-12-7), you can read my other articles.

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics