Category: 6628-83-7

Synthesis and hypotensive activity of a series of 2-substituted 5,6-dimethoxyindazoles was written by Schwan, Thomas J.;Honkomp, LeRoy J.;Davis, Charles S.;Lougheed, Guy S.. And the article was included in Journal of Pharmaceutical Sciences in 1978.Recommanded Product: 2-(Aminomethyl)tetrahydropyran This article mentions the following:

The synthesis and hypotensive activity in the dog of a series of 2-substituted 5,6-dimethoxyindazoles (e.g. I) are reported. Structure-activity relationships for this class of compounds are discussed. Indazoles containing the diethylaminoethyl, 3-pyridyl, and hydroxyethyl functions in the 2-position were the most effective in lowering blood pressure for the longest times (>270 min). In the experiment, the researchers used many compounds, for example, 2-(Aminomethyl)tetrahydropyran (cas: 6628-83-7Recommanded Product: 2-(Aminomethyl)tetrahydropyran).

2-(Aminomethyl)tetrahydropyran (cas: 6628-83-7) belongs to tetrahydropyran derivatives. Tetrahydropyran is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and dyestuff. One classic procedure for the organic synthesis of tetrahydropyran is by hydrogenation of the 3,4-isomer of dihydropyran with Raney nickel.Recommanded Product: 2-(Aminomethyl)tetrahydropyran

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

The discovery of fluoropyridine-based inhibitors of the factor VIIa/TF complex-Part 2 was written by Kohrt, Jeffrey T.;Filipski, Kevin J.;Cody, Wayne L.;Cai, Cuiman;Dudley, Danette A.;Van Huis, Chad A.;Willardsen, J. Adam;Narasimhan, Lakshmi S.;Zhang, Erli;Rapundalo, Stephen T.;Saiya-Cork, Kamlai;Leadley, Robert J.;Edmunds, Jeremy J.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2006.Recommanded Product: 2-(Aminomethyl)tetrahydropyran This article mentions the following:

The activated factor VII/tissue factor complex (FVIIa/TF) is known to play a key role in the formation of blood clots. Inhibition of this complex may lead to new antithrombotic drugs. A fluoropyridine-based series of FVIIa/TF inhibitors was discovered which utilized a diisopropylamino group for binding in the S2 and S3 binding pockets of the active site of the enzyme complex. In this series, an enhancement in binding affinity was observed by substitution at the 5-position of the hydroxybenzoic acid sidechain. An X-ray crystal structure indicates that amides at this position may increase inhibitor binding affinity through interactions with the S1’/S2′ pocket. In the experiment, the researchers used many compounds, for example, 2-(Aminomethyl)tetrahydropyran (cas: 6628-83-7Recommanded Product: 2-(Aminomethyl)tetrahydropyran).

2-(Aminomethyl)tetrahydropyran (cas: 6628-83-7) belongs to tetrahydropyran derivatives. Tetrahydropyrans are useful synthons for biologically important compounds. The bismuth chloride-assisted cross-cyclization between homoallylic alcohols and epoxides provided various benzyl tetrahydropyran derivatives. The reaction afforded good yields of desired products and occurred under mild conditions.Recommanded Product: 2-(Aminomethyl)tetrahydropyran

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics