Category: 69097-99-0

Wang, Yong published the artcile“Click” immobilized perphenylcarbamated and permethylated cyclodextrin stationary phases for chiral high-performance liquid chromatography application, Category: tetrahydropyran, the publication is Journal of Chromatography A (2010), 1217(31), 5103-5108, database is CAplus and MEDLINE.

Two cyclodextrin-based chiral stationary phases were prepared by immobilization of functionalized mono-6-azido-β-CD derivatives to alkynyl modified silica via click chem. and applied to the HPLC enantioseparation of various chiral compounds The perphenylcarbamated CD CSP (CCP-CSP) exhibited excellent chiral recognition of a wide range of analytes including racemic aryl alcs., flavonoids, bendroflumethiazide, atropine and some β-blockers. Methanol proved to be a better organic modifier than acetonitrile for most of the analytes with the exception of bendroflumethiazide. The click chem. immobilized permethylated CD CSP (CCM-CSP) afforded poor chiral recognition for most analytes, but could resolve nonaromatic ionone derivatives which were not separated on CCP-CSP. Probably resolution with cyclodextrin derived CSPs depend on a complex interplay of host’- guest’ inclusion, hydrogen bonding, π-π and hydrophobic interactions.

Journal of Chromatography A published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C33H22N4, Category: tetrahydropyran.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

He, Xiaoshu published the artcileSynthesis and characterization of homoeriodictyol and its analogs of B-ring, Product Details of C16H14O6, the publication is Yiyao Gongye (1987), 18(12), 534-7, database is CAplus.

Title compounds I (R = OH, R¹ = MeO) (6 compounds) were prepared in 5 steps starting from 1,3,5-(HO)₃C₆H₃. NMR and mass spectra of I are reported.

Yiyao Gongye published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Product Details of C16H14O6.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Zhou, Jie published the artcileCationic cyclodextrin clicked chiral stationary phase for versatile enantioseparations in high-performance liquid chromatography, Application of 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, the publication is Journal of Chromatography A (2016), 169-177, database is CAplus and MEDLINE.

A novel cationic cyclodextrin (CD) chiral stationary phase (CSPs) was developed by clicking 6^A-azido-6^C-[(3-methoxylpropyl)-1- ammonium]-heptakis[2,3-di-O-(3-chloro-4-methylphenylcarbamate)-6^B,6^D,6^E,6^F,6^G-pentakis-O-per(3-chloro-4-methylphenylcarbamate)]-β-CD chloride onto alkynyl silica support. The enantioselectivies of the as-obtained novel CSP were evaluated using 21 model racemates including flavonoids, aromatic alcs., acidic drugs, β-blocker and amino acids. Good enantioseparations were achieved in polar-organic phase HPLC, with the highest resolution of 8.07 observed for 7-methoxyflavanone. The enantioseparations in normal-phase HPLC were fine-tuned with the polarity of the mobile phase with different alcs. as organic modifiers. Improved chiral resolutions of analytes but longer retention were observed in mobile phases with decreased polarity. On comparison with previously reported clicked CD CSP, the cationic CD clicked CSP exhibited better enenatiosepns. for selected racemates even in normal-phase HPLC. 3-Methoxypropylammonium and phenylcarbamoylated moieties of the cationic CSP may provide intermol. interactions such as hydrogen bonding, π-π conjugation and dipole-dipole besides inclusion complexation to drive the enantioseparation

Journal of Chromatography A published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C18H22O4, Application of 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Fujii, Satoshi published the artcileNovel molecular conformation of (R,S)-hesperetin in anhydrous crystal, Product Details of C16H14O6, the publication is Chemical & Pharmaceutical Bulletin (1994), 42(5), 1143-5, database is CAplus.

Novel mol. conformation of racemic hesperetin, (±)-2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one, was determined by x-ray anal. A new form was crystallized from ethanol solution and its mol. conformation is quite different from that of monohydrate crystal. The aromatic ring part of benzopyrone and the Ph ring from the twist orientation (dihedral angle of two rings, Φ is 53.1(3)°), in contrast to the parallel arrangement in the monohydrate from (Φ = 0.6°). The pyrone ring forms a slightly flattened sofa conformation, where C(2) is displaced by 0.40(2) Å from the pyrone plane, in contrast to the large displacement in the monohydrate form (0.54 Å). There is a strong intramol. hydrogen bond between keto O(4) atom and hydroxy H(O5)-O(5) group which forms a six-membered ring conjugated with benzopyrone rings. The degree of conjugation is also slightly different for the two forms and may relate to the difference of hydrogen bonding network and stacking mode of aromatic rings.

Chemical & Pharmaceutical Bulletin published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Product Details of C16H14O6.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Yi, Jingxuan published the artcilePreparation and Application of Partially Substituted Phenylcarbamate-(3-(2-O-β-cyclodextrin)-2-hydroxypropoxy)-propylsilyl-Appended Silica Particles as Chiral Stationary Phase for Multi-mode HPLC, Application In Synthesis of 69097-99-0, the publication is Chromatographia (2020), 83(8), 1021-1028, database is CAplus.

Abstract: A new type of partially substituted cyclodextrin-bonded silica particles, phenylcarbamate-(3-(2-O-β-cyclodextrin)-2-hydroxypropoxy)-propylsilyl-appended silica (P-CD-HPS), has been successfully prepared and used as chiral stationary phase (CSP) in high-performance liquid chromatog. (HPLC) under normal-phase, reversed-phase, and polar organic mobile-phase conditions. The P-CD-HPS was characterized by elemental anal. and Fourier transform IR spectroscopic (FTIR) anal. The chromatog. performance of the new-phase P-CD-HPS has been evaluated in HPLC under multi-mode conditions via separating positional isomers of some disubstituted benzenes and enantiomers of some chiral drug compounds The separation results show that P-CD-HPS exhibited excellent selectivity for separating the positional isomers of nitrophenol and nitraniline and the enantiomers of some chiral drug compounds The hydroxyl residues of partially substituted β-cyclodextrin and chiral spacer linking to secondary hydroxyl site of the β-cyclodextrin in the P-CD-HPS not only have important contributions to chiral recognitions and separations, but also allow the P-CD-HPS to be used under multi-mode mobile-phase conditions in HPLC.

Chromatographia published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C4H6O3, Application In Synthesis of 69097-99-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Khan, Muhammad Kamran published the artcileChemical Synthesis of Citrus Flavanone Glucuronides, Application In Synthesis of 69097-99-0, the publication is Journal of Agricultural and Food Chemistry (2010), 58(14), 8437-8443, database is CAplus and MEDLINE.

Flavanone glucuronides are the major phenolic metabolites detected in human plasma after consumption of citrus fruits. As such, they might display significant cardioprotective effects. In this work, glucuronides of naringenin (4′- and 7-O-β-D-glucuronides) and hesperetin (3′- and 7-O-β-D-glucuronides), the major flavanone aglycons in grapefruit and orange, resp., have been chem. synthesized. On the one hand, the most reactive hydroxyl group, C7-OH, was protected by selective benzoylation to allow subsequent glucuronidation of C4′-OH (naringenin) or C3′-OH (hesperetin) (B-ring). On the other hand, the selective debenzoylation at C₇-OH of the per-benzoylated flavanone aglycons allowed glucuronidation at the same position (A-ring). After careful deprotection, the target compounds were purified and characterized by NMR and mass spectrometry.

Journal of Agricultural and Food Chemistry published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Application In Synthesis of 69097-99-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Seka, R. published the artcileNew synthesis of chrysin and other hydroxyflavones, COA of Formula: C16H14O6, the publication is Monatshefte fuer Chemie (1936), 284-91, database is CAplus.

The complex prepared from 2.4 g. 1,3,5-C₆H₃(OH)₃ and 7.5 g. AlCl₃ in 40 cc. PhNO₂ and 3.12 g. PhCCCOCl, allowed to stand 14 days at room temperature, gives chrysin (5,7-dihydroflavone), purified by distillation of the Al compound with HCl, steam distillation of the PhNO₂, sublimation of the resinous residue and extraction with boiling C₆H₆. In the same manner m-C₆H₄(OH)₂ yields 7-hydroxyflavone and 1,2,3-C₆H₃(OH)₃ gives 7,8-dihydroxyflavone. Natural and synthetic hesperetin (4′-methoxy-3′,5,7-trihydroxyflavanone), m. 233°, are purified by sublimation at 0.003-0.004 mg. Hg at a temperature not exceeding 205°; homoeriodictyol. similarly purified, m. 324° (cf. Shinoda and Kawagoye, C. A. 23, 2957; S. and Sato, C. A. 23, 4210).

Monatshefte fuer Chemie published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C5H6N2O2, COA of Formula: C16H14O6.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Edwards, J. Michael published the artcileAntitumor plants. Part VII. Antineoplastic activity and cytotoxicity of flavones, isoflavones, and flavanones, Application of 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, the publication is Journal of Natural Products (1979), 42(1), 85-91, database is CAplus and MEDLINE.

Two hundred and seventeen natural and synthetic flavonoid derivatives I, II, and III, which were tested in the screening program of the National Cancer Institute, were examd for antineoplastic activity and cytotoxicity. No structure-activity relations were observed Apparently, in spite of occasional activity these compounds do not warrant further investigation as antitumor agents.

Journal of Natural Products published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Application of 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Kumari, G. N. Krishna published the artcileCarbon-13 NMR data of flavonol methyl ethers of Solanum pubescens, HPLC of Formula: 69097-99-0, the publication is Proceedings – Indian Academy of Sciences, Chemical Sciences (1986), 97(2), 171-6, database is CAplus.

The ¹³C NMR data of flavonol 3-Me ethers indicated that the methylation of one of the OH groups in the o-dihydroxy system causes an upfield shift in the unsubstituted o-carbon as usual, but with the other hydroxylated o-carbon the shift is always downfield. The spectra of the acetates indicated that 5-acetoxy resonated downfield compared to that of other acetoxy groups. The ¹³C NMR data of these compounds is reported for the 1st time.

Proceedings – Indian Academy of Sciences, Chemical Sciences published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, HPLC of Formula: 69097-99-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Ezzat, Mohammed oday published the artcileMolecular modelling design and opioid binding affinity evaluation of new 4-chromanone derivatives, Computed Properties of 69097-99-0, the publication is Journal of Microbiology, Biotechnology and Food Sciences (2021), 10(4), 531-535, database is CAplus.

The pharmacotherapy treatment of pain is an active and motivated area of investigation for treatment with free side effects. This paper presents the docking ability of twenty-five analogs of 4-Chromanone derivatives inside the crystal structure of μ opioid receptor to estimate the binding affinity of each derivative Mol. modeling design approach applied to identify the effective substation position with generation of 989 novel 4-Chromanone derivatives The final result of the most active twenty novel 4-Chromanone derivatives with docking affinity range (-9.89 to -9.34) kcal/mol were selected as promising hit ligand drugs comparing with morphine docking affinity at (-6.02) kcal/mol.

Journal of Microbiology, Biotechnology and Food Sciences published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Computed Properties of 69097-99-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics