Category: 69097-99-0

Yanez, Jaime A. published the artcilePharmacokinetics of selected chiral flavonoids: hesperetin, naringenin and eriodictyol in rats and their content in fruit juices, Application of 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, the publication is Biopharmaceutics & Drug Disposition (2008), 29(2), 63-82, database is CAplus and MEDLINE.

The majority of pharmacokinetic studies of individual flavonoids or after ingestion of foodstuffs have overlooked the chirality of some of these xenobiotics. In order to characterize for the first time the stereoselective pharmacokinetics of three flavonoids, hesperetin, naringenin and eriodictyol were i.v. administered (20 mg/kg) to male Sprague-Dawley rats, and their stereospecific content was assessed in various fruit juices. Concentrations in serum, urine and fruit juices were characterized via HPLC and verified by LC/MS. Short half-lives (3-7 h) in serum were observed, while a better estimation of half-life (12-48 h) and the other pharmacokinetic parameters was observed using urinary data. The three flavonoids are predominantly excreted via non-renal routes (f_e values of 3-7%), and undergo rapid and extensive phase II metabolism The (2S)-epimers of the flavonoid glycosides and the S(-)-enantiomers of the aglycons were predominant and in some instances the organic fruit juices had higher concentrations than the conventional fruit juices. This study reports for the first time the stereospecific pharmacokinetics of three chiral flavonoids and their stereospecific content in fruit juices. It also reports for the first time the stereospecific pharmacokinetics of flavonoids employing urine as a more reliable biol. matrix.

Biopharmaceutics & Drug Disposition published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C12H15NO, Application of 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Ito, Chihiro published the artcileTwo flavanones from Citrus species, Category: tetrahydropyran, the publication is Phytochemistry (1989), 28(12), 3562-4, database is CAplus.

The new flavanones, hiravanone (I) and yukovanol (II) were isolated from root extracts of some Citrus species and their structures were determined by spectrometric and synthetic methods.

Phytochemistry published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Category: tetrahydropyran.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Khlebnikov, Andrei I. published the artcileImproved quantitative structure-activity relationship models to predict antioxidant activity of flavonoids in chemical, enzymatic, and cellular systems, HPLC of Formula: 69097-99-0, the publication is Bioorganic & Medicinal Chemistry (2007), 15(4), 1749-1770, database is CAplus and MEDLINE.

Quant. structure-activity relationship (QSAR) models are useful in understanding how chem. structure relates to the biol. activity of natural and synthetic chems. and for design of newer and better therapeutics. In the present study, 46 flavonoids and related polyphenols were evaluated for direct/indirect antioxidant activity in three different assay systems of increasing complexity (chem., enzymic, and intact phagocytes). Based on these data, two different QSAR models were developed using (i) physicochem. and structural (PC&S) descriptors to generate multiparameter partial least squares (PLS) regression equations derived from optimized mol. structures of the tested compounds and (ii) a partial 3D comparison of the 46 compounds with local fingerprints obtained from fragments of the mols. by the frontal polygon (FP) method. We obtained much higher QSAR correlation coefficients (r) for flavonoid end-point antioxidant activity in all three assay systems using the FP method (0.966, 0.948, and 0.965 for datasets evaluated in the biochem., enzymic, and whole cell assay systems, resp.). Furthermore, high leave-one-out cross-validation coefficients (q ²) of 0.907, 0.821, and 0.897 for these datasets, resp., indicated enhanced predictive ability and robustness of the model. Using the FP method, structural fragments (submols.) responsible for the end-point antioxidant activity in the three assay systems were also identified. To our knowledge, this is the first QSAR model derived for description of flavonoid direct/indirect antioxidant effects in a cellular system, and this model could form the basis for further drug development of flavonoid-like antioxidant compounds with therapeutic potential.

Bioorganic & Medicinal Chemistry published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, HPLC of Formula: 69097-99-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Mori, Akihisa published the artcileCytotoxicity of plant flavonoids against HeLa cells, Recommanded Product: 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, the publication is Phytochemistry (1988), 27(4), 1017-20, database is CAplus.

(-)-Epigallocatechin and 28 other plant flavonoids were tested for cytotoxic activity against HeLa cells. Flavones and flavanones were active and several compounds with planar and non-planar ring systems showed high cytotoxic activities. Although no clear structure-activity relationship was deduced, hydroxyl groups on the A- and B-ring affected the cytotoxic potency pos. or neg., depending on the position of substitution. The uptake of thymidine was predominantly inhibited by myricetin, whereas the uptake of uridine was inhibited by (-)-epigallocatechin; the uptake of both thymidine and uridine were inhibited by 7,8-dihydroxyflavone.

Phytochemistry published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Recommanded Product: 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Tong, Runna published the artcileOnline extraction-high performance liquid chromatography-diode array detector-quadrupole time-of-flight tandem mass spectrometry for rapid flavonoid profiling of Fructus aurantii immaturus, Related Products of tetrahydropyran, the publication is Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences (2018), 1-6, database is CAplus and MEDLINE.

Chem. profiling of natural products by high performance liquid chromatog. (HPLC) was critical for understanding of their clin. bioactivities, and sample pretreatment steps have been considered as a bottleneck for anal. Currently, concerted efforts have been made to develop sample pretreatment methods with high efficiency, low solvent and time consumptions. Here, a simple and efficient online extraction (OLE) strategy coupled with HPLC-diode array detector-quadrupole time-of-flight tandem mass spectrometry (HPLC-DAD-QTOF-MS/MS) was developed for rapid chem. profiling. For OLE strategy, guard column inserted with ground sample (2 mg) instead of sample loop was connected with manual injection valve, in which components were directly extracted and transferred to HPLC-DAD-QTOF-MS/MS system only by mobile phase without any extra time, solvent, instrument and operation. By comparison with offline heat-reflux extraction for Fructus aurantii immaturus (Zhishi), OLE strategy presented higher extraction efficiency perhaps because of the high pressure and gradient elution mode. A total of eighteen flavonoids were detected according to their retention times, UV spectra, exact mass, and fragmentation ions in MS/MS spectra, and compound 9, natsudaidain-3-O-glucoside, was discovered in Zhishi for the first time. It is concluded that the developed OLE-HPLC-DAD-QTOF-MS/MS system offers new perspectives for rapid chem. profiling of natural products.

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C7H5BFNO2, Related Products of tetrahydropyran.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Mistry, Bhupendra published the artcileAccess to the substituted benzyl-1,2,3-triazolyl hesperetin derivatives expressing antioxidant and anticancer effects, Computed Properties of 69097-99-0, the publication is Arabian Journal of Chemistry (2017), 10(2), 157-166, database is CAplus.

Flavanone hesperetin based Ph substituted 1,2,3-triazolyls I [R = 4-F, 2-Me, 3-Cl, etc.] was synthesized as semi-synthetic natural product derivatives by azide-alkyne cycloaddition of propargyl-hesperetin and benzyl azides, utilizing copper-catalyzed click chem. All synthesized compounds I were analyzed for their in vitro antioxidant abilities using DPPH and ABTS bioassay. Moreover, cancerous cell inhibitory prospect of titled compounds was screened against cervical cancer cell lines, HeLa and CaSki and an ovarian cancer cell line SK-OV-3 implementing SRB assay. Bearable toxicity of compounds I was examined employing Madin-Darby canine kidney (MDCK) non-cancer cell line. An analog I [R = 3-OMe] showed most potent radical scavenging activity, whereas scaffolds I [R = 4-F, 2-Me, 3-OMe] with performed excellently in inhibiting both the cervical cancer cell lines and analog I [R = 3-CF₃] expressed excellent sensitivity toward ovarian cancer cell line. From the structure-activity point of view, nature and position of the electron withdrawing and electron donating functional groups on the Ph ring attached to the triazole core may contribute to the anticipated antioxidant and anticancer action.

Arabian Journal of Chemistry published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Computed Properties of 69097-99-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Tang, Jian published the artcileEnantioseparation tuned by solvent polarity on a β-cyclodextrin clicked chiral stationary phase, Formula: C16H14O6, the publication is Journal of Separation Science (2015), 38(18), 3137-3144, database is CAplus and MEDLINE.

The efficient enantioseparation of 26 racemates was achieved with the perphenylcarbamoylated cyclodextrin clicked chiral stationary phase by screening the optimum composition of mobile phase in HPLC. The chromatog. results indicate that both the retention and chiral resolution of racemates are closely related to the polarity of the mobile phases and the structures of analytes. The addition of alcs. can significantly tune the enantioseparation in normal-phase HPLC. The addition of methanol and the ratio of ethanol/methanol or isopropanol/methanol played a key role on the resolution of flavonoids in ternary eluent systems. The chiral separation of flavonoids with pure organic solvent as mobile phase indicates the preferential order for chiral resolution is methanol>ethanol>isopropanol>n-propanol>acetonitrile.

Journal of Separation Science published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C9H22OSi, Formula: C16H14O6.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Wang, Ren-Qi published the artcileChemically bonded cationic β-cyclodextrin derivatives and their applications in supercritical fluid chromatography, Application In Synthesis of 69097-99-0, the publication is Journal of Chromatography A (2012), 97-103, database is CAplus and MEDLINE.

Cationic β-cyclodextrin (CD) perphenylcarbamoylated derivatives were chem. bonded onto vinylized silica using a radical co-polymerization reaction. The derived materials were used as chiral stationary phases (CSP) in supercritical fluid chromatog. (SFC). Enantioseparations were successfully demonstrated on 14 racemates encompassing flavanones, thiazides and amino acid derivatives The electrostatic force between the analytes and the cationic moiety on β-CD derivative is important for retention and enantioseparation of the racemates. Aromatic cationic moiety on β-CD enabled better enantioseparations than aliphatic cationic moiety. Also the presence of acid additives would result in lower retention of the analytes but often assist the chiral resolutions

Journal of Chromatography A published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C10H2F12NiO4, Application In Synthesis of 69097-99-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Wang, Ren-Qi published the artcileCationic cyclodextrins chemically-bonded chiral stationary phases for high-performance liquid chromatography, Safety of 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, the publication is Analytica Chimica Acta (2012), 121-129, database is CAplus and MEDLINE.

Two covalently bonded cationic β-CD chiral stationary phases (CSPs) prepared by graft polymerization of 6^A-(3-vinylimidazolium)-6-deoxyperphenylcarbamate-β-cyclodextrin chloride or 6^A-(N,N-allylmethylammonium)-6-deoxyperphenylcarbamoyl-β-cyclodextrin chloride onto silica gel were successfully applied in HPLC. Their enantioseparation capability was examined with 12 racemic pharmaceuticals and 6 carboxylic acids. Imidazolium-containing β-CD CSP afforded more favorable enantioseparations than that containing ammonium moiety under normal-phase HPLC. The cationic moiety on β-CD CSPs could form strong hydrogen bonding with analytes in normal-phase liquid chromatog. (NPLC) to enhance the analytes’ retention and enantioseparations In reversed-phase liquid chromatog. (RPLC), the analytes exhibited their maximum retention when the pH of mobile phase was close to their pK _a value. Inclusion complexation with CD cavity and columbic/ionic interactions with cationic substituent on the CD rim would afford accentuated retention and enantioseparations of the analytes.

Analytica Chimica Acta published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C8H10O2, Safety of 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Hu, Li-Xin published the artcileWhat is in Nigerian waters? Target and non-target screening analysis for organic chemicals, SDS of cas: 69097-99-0, the publication is Chemosphere (2021), 131546, database is CAplus and MEDLINE.

Emerging organic contaminants (e.g., active pharmaceutical ingredients and personal care products ingredients) are ubiquitous in the environment and potentially harmful to ecosystems, have gained increasing public attention worldwide. Nevertheless, there is a scarcity of data on these contaminants in Africa. In this study, various types of water samples (wastewater, surface water and tap water) collected from Lagos, Nigeria were analyzed for these chems. by both target and non-target anal. on an UHPLC-Orbitrap-MS/MS. In total, 109 compounds were identified by non-target screening using the online database mzCloud. Level 1 identification confidence was achieved for 13 compounds for which reference standards were available and level 2 was achieved for the rest. In the quant. anal., 18 of 38 target compounds were detected, including the parent compounds and their metabolites. Acetaminophen, sulfamethoxazole, acesulfame, and caffeine were detected in all samples with their highest concentrations at 8000, 5300, 16, and 7700μg/L in wastewater, 140000, 3300, 7.7, and 12000μg/L in surface water, and 66, 62, 0.17 and 1000μg/L in tap water, resp. The occurrence of psychoactive substances, anticancer treatments, antiretrovirals, antihypertensives, antidiabetics and their metabolites were reported in Nigeria for the first time. These results indicate poor wastewater treatment and management in Nigeria, and provide a preliminary profile of organic contaminants occurring in Nigerian waters. The findings from this study urge more future research on chem. pollution in the aquatic environments in Nigeria.

Chemosphere published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, SDS of cas: 69097-99-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics