Category: 82954-65-2

Application In Synthesis of (S)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)-methylamine. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (S)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)-methylamine, is researched, Molecular C6H13NO2, CAS is 82954-65-2, about Synthesis of glycidol- and sugar-derived bicyclic β- and γ/δ-amino acids for peptidomimetic design. Author is Danieli, Elisa; Trabocchi, Andrea; Menchi, Gloria; Guarna, Antonio.

Constrained bicyclic β- and γ/δ-amino acids I (R = H or CH2OBn; Fmoc = fluorenylmethoxycarbonyl, Bn = benzyl) and II were developed using glycidol and sugar derivatives The synthetic strategies involved epoxide ring opening of a glycidol derivative, and subsequent coupling with sugar-derived amines, leading to di- or trisubstituted bicyclic scaffolds after cyclization with trifluoroacetic acid. Achievement of β- or γ/δ-amino acids was accomplished by changing the protecting group strategy of the starting materials. Compatibility of the scaffold with solid-phase peptide synthesis was assessed by preparing model peptidomimetics using acid- and base-labile resins, thus giving a new tool for peptidomimetic design.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Novel synthesis and RNA-Binding properties of aminoglycoside dimers conjugated via a naphthalene diimide-based intercalator, published in 2001-11-19, which mentions a compound: 82954-65-2, mainly applied to RNA binding aminoglycoside dimer conjugated naphthalene diimide intercalator Preparation, Safety of (S)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)-methylamine.

The synthesis and RNA-binding properties of naphthalene-based diimide conjugated bis-aminoglycoside antibiotics are reported. Compared to the monomeric aminoglycoside, the conjugated ligands were observed to attain up to 35-fold enhancement in binding affinity towards a novel RNA construct that contained two 16S rRNA A-sites.

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Ubarretxena-Belandia, Iban; Cox, Ruud C.; Dijkman, Ruud; Egmond, Maarten R.; Verheij, Hubertus M.; Dekker, Niek published the article 《Half-of-the-sites reactivity of outer-membrane phospholipase A against an active-site-directed inhibitor》. Keywords: phospholipase A active site inhibitor membrane.They researched the compound: (S)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)-methylamine( cas:82954-65-2 ).Quality Control of (S)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)-methylamine. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:82954-65-2) here.

The reaction of a novel active-site-directed phospholipase A1 inhibitor with the outer-membrane phospholipase A (OMPLA) was investigated. The inhibitor 1-p-nitrophenyl-octylphosphonate-2-tridecylcarbamoyl-3-ethanesulfonylamino-3-deoxy-sn-glycerol irreversibly inactivated OMPLA. The inhibition reaction did not require the cofactor calcium or an unprotonated active-site His142. The inhibition of the enzyme solubilized in hexadecylphosphocholine micelles was characterized by a rapid (t1/2 = 20 min) and complete loss of enzymic activity, concurrent with the covalent modification of 50% of the active-site serines, as judged from the amount of p-nitrophenolate (PNP) released. Modification of the remaining 50% occurred at a much lower rate, indicative of half-of-the-sites reactivity against the inhibitor of this dimeric enzyme. Inhibition of monomeric OMPLA solubilized in hexadecyl-N,N-dimethyl-1-ammonio-3-propanesulfonate resulted in an equimolar monophasic release of PNP, concurrent with the loss of enzymic activity (t1/2 = 14 min). The half-of-the-sites reactivity is discussed in view of the dimeric nature of this enzyme.

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Tetrahydropyran – Wikipedia,
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Electric Literature of C6H13NO2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (S)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)-methylamine, is researched, Molecular C6H13NO2, CAS is 82954-65-2, about Design and preparation of a novel prolinamide-based organocatalyst for the solvent-free asymmetric aldol reaction. Author is Martins, Rafaela de S.; Pereira, Mathias P.; de Castro, Pedro P.; Bombonato, Fernanda I..

The preparation of novel organocatalysts I (R = i-Pr, i-Bu, Bn) and II as highly diastereo and enantioselective catalysts for the solvent-free asym. aldol reaction was described. These organocatalysts I and II were synthesized in eight steps applying simple and com. available starting materials. The best results were obtained for the proline-derived catalyst II, providing access to the desired adducts III (R1 = H, Me, Et; Ar = 4-nitrophenyl, naphthalen-2-yl, furan-2-yl, etc.) in up to 95% yield, 1:19 syn/anti and 98% e.e. Moreover, even sterically bulky aldehydes ArCHO and substituted cyclohexanones IV were well tolerated. DFT calculations and control experiments indicated that several hydrogen bonding interactions between the aldehyde and the enamine intermediate are responsible for the stereoselective chiral induction process and that the trifluoroacetate counter-anion is crucial for the attainment of higher stereoselectivities.

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Angrick, Michael; Rewicki, Dieter published the article 《Reactions of sugars and related polyfunctional compounds with amino acids. 2. N-Acylation of 3-amino-1,2-propanediol with amino acids》. Keywords: acylation aminopropanediol amino acid; propanediol amino acylation.They researched the compound: (S)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)-methylamine( cas:82954-65-2 ).Application In Synthesis of (S)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)-methylamine. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:82954-65-2) here.

Racemic H2NCH2CH(OH)CH2OH was N-acylated with Z-X-OH (Z = PhCH2O2C; X = Ala, Phe, Val, Leu) by 1,1′-carbonyldiimidazole in THF to give Z-X-NHCH2CH(OH)CH2OH (II). In some cases (e.g., X = Ala), one of the 2 diastereoisomers of II spontaneously formed a precipitate, which can be separated The S,S-configuration of II (X = Ala) was established by N-acylating (S)-(aminomethyl)dioxolane (S)-III (R = H) with Z-Ala-OH and cleaving the resulting (S)-III (R = Z-Ala) to give (S,S)-II (X = Ala).

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Organic Letters called Site-Selective DNA Alkylation of GG Steps by Naphthaldiimide Derivatives Possessing Enantiomeric Epoxide, Author is Okamoto, Akimitsu; Nakamura, Takashi; Yoshida, Kohzo; Nakatani, Kazuhiko; Saito, Isao, which mentions a compound: 82954-65-2, SMILESS is NC[C@@H]1OC(C)(C)OC1, Molecular C6H13NO2, Computed Properties of C6H13NO2.

We have synthesized an enantiomeric pair of novel DNA alkylating agents consisting of a naphthaldiimide intercalator and a chiral epoxy side chain. These naphthaldiimide derivatives have high DNA binding affinity and selectively alkylate 5’G of the GG steps for (S)-epoxide and 3’G for (R)-epoxide.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Computed Properties of C6H13NO2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (S)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)-methylamine, is researched, Molecular C6H13NO2, CAS is 82954-65-2, about Synthesis of glycidol- and sugar-derived bicyclic β- and γ/δ-amino acids for peptidomimetic design. Author is Danieli, Elisa; Trabocchi, Andrea; Menchi, Gloria; Guarna, Antonio.

Constrained bicyclic β- and γ/δ-amino acids I (R = H or CH2OBn; Fmoc = fluorenylmethoxycarbonyl, Bn = benzyl) and II were developed using glycidol and sugar derivatives The synthetic strategies involved epoxide ring opening of a glycidol derivative, and subsequent coupling with sugar-derived amines, leading to di- or trisubstituted bicyclic scaffolds after cyclization with trifluoroacetic acid. Achievement of β- or γ/δ-amino acids was accomplished by changing the protecting group strategy of the starting materials. Compatibility of the scaffold with solid-phase peptide synthesis was assessed by preparing model peptidomimetics using acid- and base-labile resins, thus giving a new tool for peptidomimetic design.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Formula: C6H13NO2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (S)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)-methylamine, is researched, Molecular C6H13NO2, CAS is 82954-65-2, about Helical supramolecular organization of a 1,2-diol appended naphthalene diimide organogelator via an extended intermolecular H-bonding network. Author is Shinde, Sopan Valiba; Kulkarni, Mandar; Talukdar, Pinaki.

Self-assembly of a 1,2-diol appended naphthalene diimide derivative featuring chiral and J-type aggregation was reported. In methylcyclohexane/CHCl3, the compound exhibited intense yellow excimer and thermoreversible “”sol-gel”” behavior. Morphol. and CD studies revealed long range M-helical nanofibre formation. A theor. model of the cooperative hydrogen bonding was also proposed.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Category: tetrahydropyran. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (S)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)-methylamine, is researched, Molecular C6H13NO2, CAS is 82954-65-2, about Novel synthesis and RNA-Binding properties of aminoglycoside dimers conjugated via a naphthalene diimide-based intercalator. Author is Tok, Jeffrey B.-H.; Fenker, Jason.

The synthesis and RNA-binding properties of naphthalene-based diimide conjugated bis-aminoglycoside antibiotics are reported. Compared to the monomeric aminoglycoside, the conjugated ligands were observed to attain up to 35-fold enhancement in binding affinity towards a novel RNA construct that contained two 16S rRNA A-sites.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (S)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)-methylamine, is researched, Molecular C6H13NO2, CAS is 82954-65-2, about Self-assembly of small-molecule fumaramides allows transmembrane chloride channel formation, the main research direction is selfassembly fumaramide transmembrane chloride channel.Name: (S)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)-methylamine.

This study reports the formation of self-assembled transmembrane anion channels by small-mol. fumaramides. Such artificial ion channel formation was confirmed by ion transport across liposomes and by planar bilayer conductance measurements. The geometry-optimized model of the channel and Cl- ion selectivity within the channel lumen was also illustrated.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics