Martins, Rafaela de S.; Pereira, Mathias P.; de Castro, Pedro P.; Bombonato, Fernanda I. published an article about the compound: (S)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)-methylamine( cas:82954-65-2,SMILESS:NC[C@@H]1OC(C)(C)OC1 ).COA of Formula: C6H13NO2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:82954-65-2) through the article.
The preparation of novel organocatalysts I (R = i-Pr, i-Bu, Bn) and II as highly diastereo and enantioselective catalysts for the solvent-free asym. aldol reaction was described. These organocatalysts I and II were synthesized in eight steps applying simple and com. available starting materials. The best results were obtained for the proline-derived catalyst II, providing access to the desired adducts III (R1 = H, Me, Et; Ar = 4-nitrophenyl, naphthalen-2-yl, furan-2-yl, etc.) in up to 95% yield, 1:19 syn/anti and 98% e.e. Moreover, even sterically bulky aldehydes ArCHO and substituted cyclohexanones IV were well tolerated. DFT calculations and control experiments indicated that several hydrogen bonding interactions between the aldehyde and the enamine intermediate are responsible for the stereoselective chiral induction process and that the trifluoroacetate counter-anion is crucial for the attainment of higher stereoselectivities.
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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics