Category: 82954-65-2

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (S)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)-methylamine( cas:82954-65-2 ) is researched.Electric Literature of C6H13NO2.Ubarretxena-Belandia, Iban; Cox, Ruud C.; Dijkman, Ruud; Egmond, Maarten R.; Verheij, Hubertus M.; Dekker, Niek published the article 《Half-of-the-sites reactivity of outer-membrane phospholipase A against an active-site-directed inhibitor》 about this compound( cas:82954-65-2 ) in European Journal of Biochemistry. Keywords: phospholipase A active site inhibitor membrane. Let’s learn more about this compound (cas:82954-65-2).

The reaction of a novel active-site-directed phospholipase A1 inhibitor with the outer-membrane phospholipase A (OMPLA) was investigated. The inhibitor 1-p-nitrophenyl-octylphosphonate-2-tridecylcarbamoyl-3-ethanesulfonylamino-3-deoxy-sn-glycerol irreversibly inactivated OMPLA. The inhibition reaction did not require the cofactor calcium or an unprotonated active-site His142. The inhibition of the enzyme solubilized in hexadecylphosphocholine micelles was characterized by a rapid (t1/2 = 20 min) and complete loss of enzymic activity, concurrent with the covalent modification of 50% of the active-site serines, as judged from the amount of p-nitrophenolate (PNP) released. Modification of the remaining 50% occurred at a much lower rate, indicative of half-of-the-sites reactivity against the inhibitor of this dimeric enzyme. Inhibition of monomeric OMPLA solubilized in hexadecyl-N,N-dimethyl-1-ammonio-3-propanesulfonate resulted in an equimolar monophasic release of PNP, concurrent with the loss of enzymic activity (t1/2 = 14 min). The half-of-the-sites reactivity is discussed in view of the dimeric nature of this enzyme.

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Okamoto, Akimitsu; Nakamura, Takashi; Yoshida, Kohzo; Nakatani, Kazuhiko; Saito, Isao published the article 《Site-Selective DNA Alkylation of GG Steps by Naphthaldiimide Derivatives Possessing Enantiomeric Epoxide》. Keywords: DNA alkylation guanine naphthaldiimide epoxide; enantiomer epoxide naphthaldiimide epoxide DNA.They researched the compound: (S)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)-methylamine( cas:82954-65-2 ).Electric Literature of C6H13NO2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:82954-65-2) here.

We have synthesized an enantiomeric pair of novel DNA alkylating agents consisting of a naphthaldiimide intercalator and a chiral epoxy side chain. These naphthaldiimide derivatives have high DNA binding affinity and selectively alkylate 5’G of the GG steps for (S)-epoxide and 3’G for (R)-epoxide.

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Reference:
Tetrahydropyran – Wikipedia,
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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, European Journal of Organic Chemistry called Synthesis of glycidol- and sugar-derived bicyclic β- and γ/δ-amino acids for peptidomimetic design, Author is Danieli, Elisa; Trabocchi, Andrea; Menchi, Gloria; Guarna, Antonio, which mentions a compound: 82954-65-2, SMILESS is NC[C@@H]1OC(C)(C)OC1, Molecular C6H13NO2, Related Products of 82954-65-2.

Constrained bicyclic β- and γ/δ-amino acids I (R = H or CH2OBn; Fmoc = fluorenylmethoxycarbonyl, Bn = benzyl) and II were developed using glycidol and sugar derivatives The synthetic strategies involved epoxide ring opening of a glycidol derivative, and subsequent coupling with sugar-derived amines, leading to di- or trisubstituted bicyclic scaffolds after cyclization with trifluoroacetic acid. Achievement of β- or γ/δ-amino acids was accomplished by changing the protecting group strategy of the starting materials. Compatibility of the scaffold with solid-phase peptide synthesis was assessed by preparing model peptidomimetics using acid- and base-labile resins, thus giving a new tool for peptidomimetic design.

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Tetrahydropyran – Wikipedia,
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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 82954-65-2, is researched, Molecular C6H13NO2, about Macromolecular stereochemistry: the effect of pendant group structure on the axial dimension of polyisocyanates, the main research direction is axial dimension polyisocyanate optical activity; polydimethyldioxolanemethylene isocyanate persistence length.Formula: C6H13NO2.

Chains of optically active poly[(S)-2,2-dimethyl-1,3-dioxolane-4-methylene isocyanate] (I) [107797-37-5] were more extended than those of its racemic isomer (II) [96743-47-4] and poly(n-Bu isocyanate) (III) as determined by light scattering measurements. I exhibited a CD spectrum similar to that of poly(2-methylbutyl isocyanate). The UV spectra of I and II were differed from those of III. The results were consistent with helix reversal contribution to the wormlike behavior of polyisocyanates.

There is still a lot of research devoted to this compound(SMILES：NC[C@@H]1OC(C)(C)OC1)Formula: C6H13NO2, and with the development of science, more effects of this compound(82954-65-2) can be discovered.

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Liebigs Annalen der Chemie called Reactions of sugars and related polyfunctional compounds with amino acids. 2. N-Acylation of 3-amino-1,2-propanediol with amino acids, Author is Angrick, Michael; Rewicki, Dieter, which mentions a compound: 82954-65-2, SMILESS is NC[C@@H]1OC(C)(C)OC1, Molecular C6H13NO2, Reference of (S)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)-methylamine.

Racemic H2NCH2CH(OH)CH2OH was N-acylated with Z-X-OH (Z = PhCH2O2C; X = Ala, Phe, Val, Leu) by 1,1′-carbonyldiimidazole in THF to give Z-X-NHCH2CH(OH)CH2OH (II). In some cases (e.g., X = Ala), one of the 2 diastereoisomers of II spontaneously formed a precipitate, which can be separated The S,S-configuration of II (X = Ala) was established by N-acylating (S)-(aminomethyl)dioxolane (S)-III (R = H) with Z-Ala-OH and cleaving the resulting (S)-III (R = Z-Ala) to give (S,S)-II (X = Ala).

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Synthetic Route of C6H13NO2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (S)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)-methylamine, is researched, Molecular C6H13NO2, CAS is 82954-65-2, about Synthesis of phosphonoglycine backbone units for the development of phosphono peptide nucleic acids.

A series of phosphono-modified backbone mimics based on achiral and chiral N-(dihydroxypropyl)glycine units were obtained by sequential addition of phosphonate and nucleobase moieties to suitably protected dihydroxypropylamines. Simple synthetic strategies enabled the preparation of various target derivatives that will be useful as building blocks for the preparation of new synthetic polymers containing a phosphonate internucleotide linkage in place of the standard phosphodiester bond.

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Reference:
Tetrahydropyran – Wikipedia,
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Danklmaier, Johann; Hoenig, Helmut published an article about the compound: (S)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)-methylamine( cas:82954-65-2,SMILESS:NC[C@@H]1OC(C)(C)OC1 ).Quality Control of (S)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)-methylamine. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:82954-65-2) through the article.

The syntheses of the hitherto unknown diastereomerically pure 2,6-disubstituted 3-morpholinones I [R = Me, CH2OH, (CH2)3OH] are described. The necessary educts, the optically active amino alcs. (S)-H2NCH2CH(OH)CH2OH and (S)-H2NCH2CH(OH)(CH2)3OH are synthesized by improved or new procedures. A two-step synthetic sequence via the 2-chloro-N-(2-hydroxyethyl)carboxamides leads to products much purer than those obtained by the known direct condensation of amino alcoholates with α-halogeno carboxylic esters. The structures of the title compounds are characterized by their NMR spectra.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Half-of-the-sites reactivity of outer-membrane phospholipase A against an active-site-directed inhibitor, published in 1999-03-31, which mentions a compound: 82954-65-2, Name is (S)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)-methylamine, Molecular C6H13NO2, Synthetic Route of C6H13NO2.

The reaction of a novel active-site-directed phospholipase A1 inhibitor with the outer-membrane phospholipase A (OMPLA) was investigated. The inhibitor 1-p-nitrophenyl-octylphosphonate-2-tridecylcarbamoyl-3-ethanesulfonylamino-3-deoxy-sn-glycerol irreversibly inactivated OMPLA. The inhibition reaction did not require the cofactor calcium or an unprotonated active-site His142. The inhibition of the enzyme solubilized in hexadecylphosphocholine micelles was characterized by a rapid (t1/2 = 20 min) and complete loss of enzymic activity, concurrent with the covalent modification of 50% of the active-site serines, as judged from the amount of p-nitrophenolate (PNP) released. Modification of the remaining 50% occurred at a much lower rate, indicative of half-of-the-sites reactivity against the inhibitor of this dimeric enzyme. Inhibition of monomeric OMPLA solubilized in hexadecyl-N,N-dimethyl-1-ammonio-3-propanesulfonate resulted in an equimolar monophasic release of PNP, concurrent with the loss of enzymic activity (t1/2 = 14 min). The half-of-the-sites reactivity is discussed in view of the dimeric nature of this enzyme.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Name: (S)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)-methylamine. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (S)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)-methylamine, is researched, Molecular C6H13NO2, CAS is 82954-65-2, about Self-assembly of small-molecule fumaramides allows transmembrane chloride channel formation. Author is Roy, Arundhati; Gautam, Amitosh; Malla, Javid Ahmad; Sarkar, Sohini; Mukherjee, Arnab; Talukdar, Pinaki.

This study reports the formation of self-assembled transmembrane anion channels by small-mol. fumaramides. Such artificial ion channel formation was confirmed by ion transport across liposomes and by planar bilayer conductance measurements. The geometry-optimized model of the channel and Cl- ion selectivity within the channel lumen was also illustrated.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (S)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)-methylamine( cas:82954-65-2 ) is researched.Application of 82954-65-2.Angrick, Michael; Rewicki, Dieter published the article 《Reactions of sugars and related polyfunctional compounds with amino acids. 2. N-Acylation of 3-amino-1,2-propanediol with amino acids》 about this compound( cas:82954-65-2 ) in Liebigs Annalen der Chemie. Keywords: acylation aminopropanediol amino acid; propanediol amino acylation. Let’s learn more about this compound (cas:82954-65-2).

Racemic H2NCH2CH(OH)CH2OH was N-acylated with Z-X-OH (Z = PhCH2O2C; X = Ala, Phe, Val, Leu) by 1,1′-carbonyldiimidazole in THF to give Z-X-NHCH2CH(OH)CH2OH (II). In some cases (e.g., X = Ala), one of the 2 diastereoisomers of II spontaneously formed a precipitate, which can be separated The S,S-configuration of II (X = Ala) was established by N-acylating (S)-(aminomethyl)dioxolane (S)-III (R = H) with Z-Ala-OH and cleaving the resulting (S)-III (R = Z-Ala) to give (S,S)-II (X = Ala).

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics