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A class of piperazine and related heterocyclic derivatives, substituted at the 4-position by a substituted aryl or heteroaryl moiety, and at the 1-position by an ethylsulfonyl group which in turn is substituted at the 2-position by a hydroxamic acid moiety and also by a range of alternative substituents, being potent inhibitors of CD23 shedding, are useful in the treatment and/or prevention of allergic, inflammatory and neoplastic diseases.

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Reference:
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The invention belongs to the technical field of chemical medicine, relates to bridge piperazine derivative or its salt and its preparation method, and the states the bridge arch piperazine derivative or a salt thereof in the preparation in the treatment of diseases associated with the ROR gamma t use in the medicament. By experiment, the results display, of the bridge of the present invention can effectively inhibit the piperazine derivatives ROR gamma t protein receptor, regulating Th17 cell differentiation, inhibiting IL – 17 production, can be further used to treat ROR gamma t-mediated inflammation-related drug for the treatment of such diseases, especially suitable for the treatment of multiple sclerosis, rheumatoid arthritis, collagen induced arthritis, psoriasis, inflammatory bowel disease, encephalomyelitis, cloning disease, asthma, inflammation-related diseases such as cancer. (by machine translation)

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Tetrahydropyran – Wikipedia,
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Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain

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Tetrahydropyran – Wikipedia,
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This invention relates to compounds of formula I 1 whereinR1 and R2 are defined herein, or a pharmaceutically acceptable salt thereof.It has been found that the compounds of formula I are adenosine receptor ligands with good affinity to the A2A-receptor and a high selectivity to the A1- and A3 receptors. These compounds are useful, inter alia, in treatment of Alzheimer”s disease, depression, Parkinson”s disease and ADHD.

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The present invention includes methods of stabilizing one or more sweet enhancers when they are exposed to a light source as well as liquid compositions containing one or more sweet enhancers and one or more photostabilizers.

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The present invention relates to substituted pyrrolopyridinones and substituted pyrazolopyridinones which are inhibitors of BET proteins such as BRD2, BRD3, BRD4, and BRD-t and are useful in the treatment of diseases such as cancer.

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The invention relates to a method of manufacturing one kind of nitrile, compared with the prior art, has significantly reduced the amount of ammonia, the environmental pressure of the small, low energy consumption, low production cost, nitrile product purity and yield and the like, and can obtain more complex structure of the nitriles. The invention also relates to the corresponding amine by the nitrile manufacture method. (by machine translation)

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A class of piperidine and related heterocyclic derivatives, C-substituted by a substituted aryl or heteroaryl moiety, and N-substituted by an ethylsulfonyl group which in turn is substituted at the 2-position by a hydroxamic acid moiety and also by a range of alternative substituents, being potent inhibitors of CD23 shedding, are useful in the treatment and/or prevention of allergic, inflammatory and neoplastic diseases.

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Compounds of formula (I) can modulate the activity of autotaxin (ATX).

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There are described compounds of formula (I): and there use as a medicament in the treatment of conditions involving abnormal activation and/or malfunction of the of the hedgehog pathway, such as cancer, fibrosis and chronic graft-versus-host disease (cGVHD).

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics