Analyzing the synthesis route of 85064-61-5

The synthetic route of 85064-61-5 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.85064-61-5,Tetrahydropyranyl-4-acetic acid,as a common compound, the synthetic route is as follows.

At room temperature, to the containing 1-(3-(3-amino-5-chloro-2-methylbenzyl)-3,8-diazabicyclo[3.2.1]octan-8-yl)-2-cyclobutylethan-1-one (150.0 mg, 0 . 42 mmol) in dichloromethane solution, adding N, N – diisopropyl ethylamine (160.8 mg, 1 . 25 mmol) and tetrahydropyran-4-acetic acid (66.3 mg, 0 . 46 mmol), addition of HATU (399.2 mg, 1 . 05 mmol), after the adding of, for stirring the reaction overnight at room temperature. After the reaction is complete, the solvent is removed under reduced pressure, the residue by silica gel column chromatography (petroleum ether: ethyl acetate=5:1 – 1:1) and thick preparation plate purification to obtain white solid compound 15.0 mg, yield 7.3percent.

The synthetic route of 85064-61-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Fudan University; Wang Yonghui; Tian Jinlong; Yu Mingcheng; (29 pag.)CN109134476; (2019); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

Some tips on 85064-61-5

85064-61-5 Tetrahydropyranyl-4-acetic acid 2773575, aTetrahydropyrans compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.85064-61-5,Tetrahydropyranyl-4-acetic acid,as a common compound, the synthetic route is as follows.

Lambda^Lambda^-dimethylformamide (0.27 mL, 3.47 mmol) was added to a solution of tetrahydropyranyl-4-acetic acid (5.0 g, 34.7 mmol) and thionyl chloride (2.53 mL, 34.7 mmol) in DCM (200 mL) at 0 ¡ãC. After stirring 1 h at RT the solution was cooled to 0 ¡ãC. 7V-Ethyl-A sopropylpropan-2 -amine (15.14 mL, 87 mmol) was added, followed by 4- bromoaniline (5.97 g, 34.7 mmol) in 20 mL DCM were added slowly and the solution was stirred at 0 ¡ãC. After 1 h the reaction was diluted with saturated ammonium chloride and the organics were removed. Ethyl acetate was added and the layers were separated. The aqueous layer was extracted with EtOAc. The combined organic extracts were washed with water, saturated sodium chloride, and dried over sodium sulfate. The solution was filtered and concentrated in vacuo to give the crude material N-(4- bromophenyl)-2-(tetrahydro-2//-pyran-4-yl)acetamide as a tan solid.

85064-61-5 Tetrahydropyranyl-4-acetic acid 2773575, aTetrahydropyrans compound, is more and more widely used in various.

Reference£º
Patent; AMGEN INC.; PARAS, Nick A,; BROWN, James; CHENG, Yuan; HITCHCOCK, Stephen; JUDD, Ted; LOPEZ, Patricia; MINATTI, Ana Elena; NIXEY, Thomas; POWERS, Timothy; TEGLEY, Christopher M.; XUE, Qiufen; YANG, Bryant; ZHONG, Wenge; WO2011/90911; (2011); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics