Category: 951127-25-6

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 951127-25-6, Name is tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate, Recommanded Product: tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate.

An amino-tetrahydropyran derivatives and their use in medicine (by machine translation)

An amino-tetrahydropyran derivatives and their use in medicine. The invention relates to a novel structure of the structural formula (I) substituted amino tetrahydropyran, its for inhibitors of dipeptidyl peptidase – IV and can be used for with the dipeptidyl peptidase – IV of the related to the treatment or prevention of diseases, such as diabetes and in particular II type diabetes. The invention also relates to pharmaceutical compositions comprising these compounds, and these compounds and compositions in the dipeptidyl peptidase – IV relating to the prevention of such diseases or of use in the treatment. (by machine translation)

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Recommanded Product: tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate. In my other articles, you can also check out more blogs about 951127-25-6

Reference£º
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 951127-25-6, Name is tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate, molecular formula is C16H19F2NO4. In a Article£¬once mentioned of 951127-25-6, Application In Synthesis of tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate

An Alternative Scalable Process for the Synthesis of the Key Intermediate of Omarigliptin

An alternative scalable process for the synthesis of the key intermediate of omarigliptin is described. The asymmetric synthesis relies on the initial diastereoselective alkylation and subsequent aluminum-catalyzed substrate-controlled Meerwein-Ponndorf-Verley reduction. A highly regioselective 5-exo-dig iodocyclization followed to afford 11b, which was then subjected to ring-opening cycloetherification to give product 1 with >99:1 dr and >99% ee in 31.2% overall yield in nine steps. This synthetic strategy has been successfully applied for multikilogram scale production.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application In Synthesis of tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate. In my other articles, you can also check out more blogs about 951127-25-6

Reference£º
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.951127-25-6, Name is tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate, molecular formula is C16H19F2NO4. In a Patent£¬once mentioned of 951127-25-6, category: Tetrahydropyrans

NOVEL CRYSTALLINE FORMS OF A DIPEPTIDYL PEPTIDASE-IV INHIBITOR

Novel crystalline forms of (2R,3S,5R)-2-(2,5-Difluorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-2H-pyran-3-amine are potent inhibitors of dipeptidyl peptidase-IV and are useful for the treatment of non-insulin dependent (Type 2) diabetes mellitus. The invention also relates to pharmaceutical compositions containing these novel forms, processes to prepare these forms and their pharmaceutical compositions as well as uses thereof for the treatment of Type 2 diabetes.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.category: Tetrahydropyrans, you can also check out more blogs about951127-25-6

Reference£º
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Application of 951127-25-6, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 951127-25-6, Name is tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate, molecular formula is C16H19F2NO4. In a Patent£¬once mentioned of 951127-25-6

Amino six member ring derivatives and their use in medicine (by machine translation)

The invention relates to a six-member ring amino derivatives and its application in medicine, specifically relates to the general formula (I) as shown by the six-member ring of the amino derivative or its stereoisomer, pharmaceutically acceptable salt, prodrug, pharmaceutical composition containing the derivative of the dipeptidyl peptidase IV and the preparation (dPP CGI-iV) inhibitors of their medical use, wherein the general formula (I) definition of each substituent in the definition of the description of the same. (by machine translation)

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 951127-25-6 is helpful to your research., Application of 951127-25-6

Reference£º
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

In an article, published in an article, once mentioned the application of 951127-25-6, Name is tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate,molecular formula is C16H19F2NO4, is a conventional compound. this article was the specific content is as follows.Computed Properties of C16H19F2NO4

A chiral amino pyrone compound synthesis method (by machine translation)

The invention relates to a chiral amino pyrone synthetic method of compound, and the reaction of the intermediate product N – Boc – 1 – (2, 5 – difluorophenyl) -1 – oxo – 2 – S – amino fifth heavenly stem -4 alkynal pure S chiral configuration, the synthesis reaction is: (by machine translation)

Do you like my blog? If you like, you can also browse other articles about this kind. Computed Properties of C16H19F2NO4. Thanks for taking the time to read the blog about 951127-25-6

Reference£º
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.951127-25-6, Name is tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate, molecular formula is C16H19F2NO4. In a Patent£¬once mentioned of 951127-25-6, Recommanded Product: 951127-25-6

SUBSTITUTED AMINO SIX-MEMBERED SATURATED HETEROCYCLIC FAT USED AS LONG-ACTING DPP-IV INHIBITOR

The present application relates to a substituted amino six-membered saturated heteroalicycle represented by formula I as a long-acting DPP-IV inhibitor, a method for preparing the same, a pharmaceutical composition comprising the same, and a use of the same in treating and/or preventing diseases and disorders benefitting from DPP-IV inhibition.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 951127-25-6 is helpful to your research., Recommanded Product: 951127-25-6

Reference£º
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn¡¯t involve a screen. 951127-25-6, C16H19F2NO4. A document type is Patent, introducing its new discovery., Recommanded Product: tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate

A dipeptidyl peptidase – IV inhibitors (by machine translation)

The invention provides general formula (I) amino-tetrahydropyran derivatives, their pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, and its preparation method and comprise the compound of the pharmaceutical composition. The compound can inhibit the dipeptidyl peptidase IV (DPP – IV) activity, can be used for treating diseases associated with dipeptidyl peptidase IV, in particular to the treatment of diabetes. (by machine translation)

Interested yet? Keep reading other articles of 951127-25-6!, Recommanded Product: tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate

Reference£º
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

951127-25-6, Name is tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate, molecular formula is C16H19F2NO4, belongs to Tetrahydropyrans compound, is a common compound. In a patnet, assignee is FAN, JIANG951127-25-6, once mentioned the new application about 951127-25-6

Three member fused ring substituted amino six-member ring derivatives and their use in medicine (by machine translation)

The invention relates to a three-member fused ring substituted amino six-member ring derivatives and their use in medicine, in particular with regard to the general formula (I) as shown by a three-member fused ring substituted amino six-member ring derivative or its stereoisomer, pharmaceutically acceptable salt, prodrug, pharmaceutical composition containing the derivative of the dipeptidyl peptidase IV and the preparation (dPP CGI-iV) inhibitors of their medical use, wherein the general formula (I) definition of each substituent in the definition of the description of the same. (by machine translation)

Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 951127-25-6, 951127-25-6

Reference£º
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

951127-25-6,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.951127-25-6,tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate,as a common compound, the synthetic route is as follows.

9c (0.40 g, 1.23 mmol) was dissolved in dimethylacetamide (5 mL) at room temperature, and intermediate 1 (0.33 g, 1.0 mmol) was added and stirred at room temperature for 1 hour.Sodium tris (acetoxy) borohydride (028 g, 1.3 mmol) was added to the reaction solution and allowed to react at room temperature for 16 hours.The reaction solution was cooled to 0 C, water (20 mL) and aqueous ammonia (2 mL) were successively added to precipitate a white solid.The reaction solution was filtered and the cake was washed successively with water (10 mL x 2), petroleum ether (10 mL x 1).The filter cake was dissolved in dichloromethane (50 mL), dried over anhydrous magnesium sulfate,The filtrate was concentrated under reduced pressure to give a pale yellow solid 9d (0.22 g, yield 45.9%).

The synthetic route of 951127-25-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sichuan Haisco Pharmaceutical Co.,Ltd; FAN, JIANG; CHEN, QINGPING; JIANG, WEI; ZHENG, SUXIN; YE, FEI; (128 pag.)TW2017/8221; (2017); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.951127-25-6,tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate,as a common compound, the synthetic route is as follows.

951127-25-6, N-[(2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydropyran-3-yl]carboxylic acidTert-butyl ester(0.25g,0.76 mmol) was dissolved in N,N-dimethylacetamide (3.3 mL).2-[(5-Methyl-2-thienyl)sulfonyl]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole 4-methylbenzenesulfonate (0.47 g) , 1.06mmol), react at room temperature for 10 minutes,Nitrogen protection, sodium triacetoxyborohydride (0.89 g, 4.19 mmol) was slowly added at 0 C.The reaction was resumed at room temperature for 12 hours. The reaction was quenched by the addition of aqueous ammonia/water (v/v = 2/3, 50 mL).filter,The obtained solid was subjected to silica gel column chromatography[Methanol/dichloromethane (v/v) = 1/9] purified,The title compound (0.41 g, yield 92%) was obtained.It is a white solid.

As the paragraph descriping shows that 951127-25-6 is playing an increasingly important role.

Reference£º
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Ruyuan Yong Xing Technology Services Co., Ltd.; Li Jianhao; Gu Zheng; Deng Xinshan; Tang Wanjun; Zhang Zongyuan; Kang Panpan; Yuan Weihui; Peng Fei; (49 pag.)CN109942583; (2019); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics